A genetic switch : phage λ and higher organisms

著者

書誌事項

A genetic switch : phage λ and higher organisms

by Mark Ptashne

Cell Press : Blackwell Scientific Publications, [1998]

2nd ed., revized printing

  • : paper

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注記

Includes bibliographical references and index (p.187-192)

"This printing differs from the previous edition in that a description of 'GAL11P' has been omitted from Chapter 6" -- Preface to the second edition, addendum: revised printing, april 1998

内容説明・目次

内容説明

A Genetic Switch is concerned with how a virus called lambda uses its genes - its DNA - to direct its growth. Biologists have long wished to know how genes are 'switched' on and off during development and, aberrantly, in diseased states.

目次

  • 1. The Master Elements of Control:Components of the SwitchThe Action of Repressor and CroInduction - Flipping the SwitchCooperativity - Switch Stability and SensitivityThe Effect of AutoregulationOther Cases2. Protein-DNA Interactions and Gene Control:The OperatorRepressorCroAmino Acid-Base Pair InteractionsThe PromoterGene Control3. Control Circuits - Setting the Switch:A Brief Overview of Lambda GrowthControl of TranscriptionThe DecisionControl of Integration and ExcisionOther PhagesThe SOS ResponsePathways and Cell Development4. How do we Know - The Key Experiments:The Repressor IdeaThe Repressor Problem in the Early 1960sRepressor Isolation and DNA-BindingMaking More RepressorThe Claims of Chapters One and Two5. Eukaryotic Gene Regulation - An Overview:IntroductionEukaryotic Genes and their PolymerasesActivationRepressionCooperativityRegulators Assembled for Non-identical ComponentsSpeculations on Development and EvolutionCaveats6. Eukaryotic Gene Regulation - Experiments and Examples:BackgroundTwo Functions of an Activator: DNA Binding and ActivationDNA Binding StructuresActivating RegionsAction at a Distance- LoopingActivation In Vivo and In VitroSquelchingRepressionRegulators Assembled from Non-identical ComponentsMore CooperativityThe Case of EveConclusion
  • Appendix OneDesigning an Efficient DNA-binding ProteinAppendix TwoStrong and Weak InteractionsAppendix ThreeControl of Transcription in Eukaryotes and Prokaryotes - a common mechanism

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