Drug targeting : organ-specific strategies
著者
書誌事項
Drug targeting : organ-specific strategies
（Methods and principles in medicinal chemistry / edited by R. Mannhold ... [et al.], v. 12）
Wiley-vch, c2001
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注記
Includes index
内容説明・目次
内容説明
How are medicines transported intact through the body to their specific target sites without triggering side effects? The answer is "Drug Targeting". This thoroughly application--oriented book gives comprehensive answers to this and many other questions that confront scientists daily in chemical, pharmaceutical and medical research. A concise overview of the most important basic theories, modern forms of therapy and molecular biological tools, it represents a comprehensible introduction to the topic. The book then goes on to deal with strategies for target applications, divided according to target site, for example brain, lungs, liver, blood vessels and tumor cells. The third part is devoted to special, modern techniques, from phage display methods, via the use of tissue slices right up to pharmacokinetic modeling. Throughout, the focus remains on the practical aspect and successful application of the method in question, although a glance at what the future holds is also included. A volume that every pharmaceutically oriented research group should own.
目次
Preface. Foreword. List of Contributors. Drug Targeting: Basic Concepts and Novel Advances (G. Molema). Brain-Specific Drug Targeting Strategies (U. Bickel, et al.). Pulmonary Drug Delivery: Delivery to and Through the Lung (A. de Boer, et al.). Cell Specific Delivery of Anti-Inflammatory Drugs to Hepatic Endothelial and Kupffer Cells for the Treatment of Inflammatory Liver Diseases (B. Melgert, et al.). Delivery of Drugs and Antisense Oligonucleotides to the Proximal Tubular Cell of the Kidney Using Macromolecular and Pro-drug Approaches (M. Haas, et al.). A Practical Approach in the Design of Colon-specific Drug Delivery Systems (C. Leopold). Vascular Endothelium in Inflamed Tissue as a Target for Site Selective Delivery of Drugs (M. Everts, et al.). Strategies for Specific Drug Targeting to Tumour Cells (J. Kosterink, et al.). Tumour Vasculature Targeting (D. van der Schaft, et al.). Phage Display Technology for Target Discovery in Drug Delivery Research (R. Muttuberria, et al.). Development of Proteinaceous Drug Targeting Constructs Using Chemical and Recombinant DNA Approaches (R. Kok, et al.). Use of Human Tissue Slices in Drug Targeting Research (P. Olinga & G. Groothuis). Pharmacokinetic/Pharmacodynamic Modelling in Drug Targeting (J. Proost). Drug Targeting Strategy: Scrutinize the Concepts Before Screening the Constructs (D. Meijer). Index.
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