Neurobiology of alzheimer's disease
著者
書誌事項
Neurobiology of alzheimer's disease
（The molecular and cellular neurobiology series）
Oxford University Press, 2001
- hbk
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注記
Includes index
内容説明・目次
内容説明
This new edition of a book first published in 1995, presents an accessible and up-to-date overview of Alzheimer's disease, with an emphasis on research into the molecular mechanisms of neuronal degeneration. Leading international experts have provided in-depth reviews of their areas of expertise, including coverage of the key molecules known to be involved, such as As, tau, apolipoprotein E and the presenilins. Other areas covered include neuropathology, genetics, neurochemical pathology, inflammation, diagnosis, models of the disease and opportunities for treatment, employing both current and emerging drug therapies. The book will provide a readable introduction for those new to the subject, as well as covering a wide range of specialist topics for the more experienced researcher and those interested in the overlap with other related specialist areas. Also included are appendices detailing gene and protein information on APP, tau, the presenilins, apolipoprotein E and the newly cloned therapeutic target, BACE.
目次
- 1. Alzheimer's Disease: past, present and future themes
- 2. The neuropathology of Alzheimer's Disease
- 3. Molecular genetics of Alzheimer's Disease
- 4. The biology and molecular neuropathology of beta-amyloid protein
- 5. The molecular basis of Tau protein pathology in Alzheimer's Disease and related neurodegenerative dementias
- 6. Apolipoprotein E as a risk factor for Alzheimer's Disease
- 7. The presenilin genes
- 8. Transgenic models of Alzheimer's Disease neuropathology
- 9. Cellular targets of amyloid beta peptide: potential roles in neuronal cell stress and toxicity
- 10. Reflections on Alzheimer's Disease as a specific neurotransmitter disorder
- 11. Clinical assessment of Alzheimer's Disease
- 12. Molecular and biological markers for the diagnosis and monitoring of the progression of Alzheimer's Disease
- 13. Alzheimer's Disease and neuroimaging
- 14. Current pharmacological approaches to treating Alzheimer's Disease
- 15. Current perspectives, future directions
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