Brain disease : therapeutic strategies and repair
著者
書誌事項
Brain disease : therapeutic strategies and repair
Martin Dunitz ; c2002
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Recent research has unearthed new insights into brain disease. In this volume, leading scientists review the latest experimental and clinical findings on how the central nervous system (CNS) responds to injury. Brain Disease encompasses the mechanisms of CNS disorders, such as multiple sclerosis, Alzheimer's disease, stroke and traumatic brain injury. Attention is focused on the role of genetic and environmental factors, pathophysiology of immune-mediated brain injury, blood-brain barrier eruption and brain edema, apoptotic mechanisms, cytokines, chemokines and the matrix metalloproteinases (MMPs). Other topics include repair mechanisms, gene therapy and the use of stem cells for CNS remyelination, regeneration, neurogenesis and compensatory plasticity. Brain Disease is indispensable for practicing neurologists, neurosurgeons, geriatricians and students in those fields.
目次
- The Spectrum of Neuroimmunologic Diseases. Heterogeneity in Multiple Sclerosis. Microglia and Brain Macrophages. Humoral Immune Response and Antibody-Mediated Brain Injury. Antibody-Mediated Remyelination. Apoptosis in Multiple Sclerosis and Experimental Autoimmune Encephalomyehtis. Cell Migration and Adhesion Molecules at the Blood-Brain Barrier in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis. Matrix Metalloproteinases and Their Inhibitors in Brain Injury and Repair. Monitoring Progression of Multiple Sclerosis. Immunomodulation and Therapy in Multiple Sclerosis. Immunogene Therapy for Autoimmune Demyelination. DNA Vaccination for Central Nervous System Autoimmune Diseases. Stem Cell Transplantation for Neurological Diseases: New Hope for Disorders of Myelin? Viruses in Neurological Diseases. Chronic Fatigue Syndrome and Systemic Viral Infections: Current Evidence and Recent Advances. Bacterial Meningitis. Human Prion Diseases. Neurologic Manifestations of Lymphoproliferative Disorders. Cerebrovascular Disorders: Therapeutic Strategies and Repair. Vasculitis of the Nervous System. Brain Vasculitis and Antiphospholipid Syndrome. Neuronal Protection in Cerebral Ischemia - from Lessons of the Past to a Brighter Future. lmmunomodulation - New Therapeutic Opportunities for Stroke. Toxicity of Tumor Necrosis Factor is Enhanced by Reactive Oxygen Species After Brain Trauma. Protective Autoimmunity: is Vaccination for Neurodegenerative Disorders Feasible? The Molecular Biology of Blood-Brain Barrier Disruption Under Stress
- the Potential Involvement of Acetylcholinesterase. Clinically Important Interactions Involving New Antiepileptic Drugs. Challenges in Monitoring the New Antiepileptic Drugs. Aggravation of Seizures by Antiepileptic Drugs: Pathophysiology and Clinical Implications. Management of Paroxysmal Symptoms in Multiple Sclerosis. An Update on Therapy for Parkinson's Disease. Restoring Structure and Function of the Nigrostriatal System in Parkinson's Disease. Therapy of Hyperkinetic Movement Disorders. Molecular Events in Dopaminergic Neurodegeneration and Neuroprotection in MPTP Model of Parkinson's Diseases Employing cDNA Microarray. Alzheimer's Disease. Vasculitic Neuropathies. Acquired Demyelinating Neuropathies: Molecular Mechanisms and Novel Therapeutic Approaches. Radiation Damage to Peripheral Nerves. Neuropathy Due to Malignant Hematological Disease. Hereditary Inclusion Body Myopathies: Clinical and Genetic Features. Exercise Testing in Muscle Disease. Disorders in Emotional Behavior. Cognitive and Affective Disturbances in Multiple Sclerosis. From Spinal Shock to Spasticity. Pathophysiology and Treatment of Fatigue in Multiple Sclerosis. Management of Vertigo and Vestibular Disorders. Eye Movements: Supranuclear Mechanisms and Their Disorders. The Role of Radionucleide Brain Scan and Multimodality. Imaging Brain Inflammation. Advances in Neurosonology. Neurophysiology of Inflammatory Demyelinating Disease.
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