Neurotransmitters and neuromodulators : handbook of receptors and biological effects
著者
書誌事項
Neurotransmitters and neuromodulators : handbook of receptors and biological effects
Wiley-VCH, c2002
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
What are the biological effects of neuropeptides and other neuroactive substances? What are their receptors, their pharmaceutical applications? The intensive search for answers to these questions culminated in the 2000 Nobel Prize for Medicine/Physiology being awarded to A. Carlsson, P. Greengard, and E. Kandel for their pioneering research in signal transduction in the nervous system. This handbook gives a short but detailed overview of neuroactive substances, covering all neurotransmitters and most neuromodulators. It provides clear and comprehensive information on their biosynthesis and degradation, localization, receptors, signal transduction pathways, and biological effects in the central nervous system. Introductory chapters on general aspects and on methods for analyzing neuroactive substances make this a valuable tool for researchers, teachers, and advanced students in molecular biology, biochemistry, medicine, neurosciences, pharmacology, and physiology.
目次
Preface.INTRODUCTION. Neuroactive Substances. Receptors and Transporters. Distribution and Localization of Neurotransmitters and Neuromodulators. The Blood--Brain Barrier. Volume Transmission and Wiring Transmission. METHODS. Bio-- and Radioisotope Assays. Microdialysis and Electrochemical Detection. Chromatography. Autoradiography. Immunohistochemical Methods. In--situ Hybridization. Staining and Neuroanatomical Tract Tracing. Electrophysiology. Behavioral Testing. NEUROTRANSMITTERS. Acetylcholine. Dopamine. GABA (Gamma--Amino Butyric Acid). Glutamate and Aspartate. Glycine. Histamine. Norepinephrine. Serotonin (5--hydroxytryptamine). NEUROMODULATORS. Adrenocorticotropic Hormone (ACTH). Anandamide. Angiotensin. Atrial Natriuretic Factor. Calcitonin and Calcitonin Gene--Related Protein. Cholecystokinin. Corticotropin--Releasing Factor (CRF). Dynorphin. Eicosanoids and Arachidonic Acid. Endorphin. Enkephalin. Galanin. Growth Hormone--Releasing Hormone. Gonadotropin--Releasing Hormone. Interleukin. Melanin--Concentrating Hormone. Melanocyte--Stimulating Hormone. Neurotensin. Nitric Oxide. Nociceptin (Orphanin FQ). Neuropeptide Y. PACAP (pituitary adenylate cyclase--activating polypeptide). Proopiomelanocortin. Purines. Somatostatin. Substance P and Tachykinins. Thyrotropin--Releasing Hormone. Tyr--MIF--1 Family. Vasoactive Intestinal Polypeptide (VIP). Vasopressin and Oxytocin.Appendix 1: Amino Acids.Appendix 2: Nucleotides.Appendix 3: Abbreviations for Neurotransmitters and Neuromodulators.Appendix 4: Miscellaneous Abbreviations (Enzymes and Transporter).Index.
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