Chloride channels
著者
書誌事項
Chloride channels
Isis Medical Media, c1999
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Chloride Channels summarizes progress on each of the major classes of anion channels and relates this to what is known of their molecular biology and electrophysiology. A team of international specialists gives significant new insights into the physiological and pathophysiological role of chloride channels in many cell types and molecular techniques, focusing collectively on specific aspects of chloride channel function and regulation and also discussing their more general importance in human physiology and disease. The text describes in vitro and in vivo observations supported, where possible, by basic pharmacological observations dovetailed with results of molecular experiments, and the concluding chapter reviews the therapeutic potential of chloride channel modulation that is likely to follow the success of calcium, potassium and sodium channel modulators in the treatment of disease.
目次
1. Introduction 2. CLC Chloride Channels 3. Cell Volume Regulation Reduced to Size 4. Cell Swelling-Activated Chloride Channels and Their Regulation by P-Glycoprotein 5. VRAC: a Multifunctional Volume-Regulated Anion Channel in Vascular Endothelium 6. Regulation of a Swelling-Activated Anion Channel by Intracellular Ionic Strength and ATP Concentration 7. Functional Role of CFTR Chloride Channels in Airway and Gut Epithelia 8. Epithelial Chloride Secretion and its Pharmacological Inhibition 9. Volume-Regulated Chloride Channels in Heart and Smooth Muscle 10. Properties and Role of Chloride Channels in Smooth Muscle 11. A Novel 'Anion Channel' in the Malaria-Infected Erythrocyte: Opportunities for Antimalarial Chemotherapy 12. Transmitter Gated Chloride Channels: Common and Divergent Features 13. The Influence of Transmembrane Amino Acid Residues Upon Allosteric Modulation of Transmitter-Gated Anion Channels by Convulsants and General Anaesthetics 14. Chloride Channels: Potential Therapeutic Targets?
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