The genetic basis of human cancer

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The genetic basis of human cancer

editors, Bert Vogelstein, Kenneth W. Kinzler

McGraw-Hill, Medical Publishing Division, c2002

2nd ed.

大学図書館所蔵 件 / 全19件

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Includes Indexes

内容説明・目次

内容説明

Reveals what leading experts have recently discovered about cancers caused by DNA alterations!The second edition of THE GENETICS OF CANCER, newly titled THE GENETIC BASIS OF HUMAN CANCERS, updates and informs on the most recent progress in genetic cancer research and its impact on patient care. With contributions by the foremost authorities in the field, this fascinating new edition reports on how to understand and predict tumor development - information that can enhance decision-making and advance genetic research.2ND Edition HighlightsNEW CHAPTERS: * Peutz-Jeghers syndrome * Juvenile polyposis syndrome * Tumor genome instability * Gene expression profiling in cancer * Pilomatricoma and pilomatrix carcinoma * Hereditary paragangliomas of the head and neck * Cylindromatosis * Familial cardiac myxomas and carney complex * Cancers of the oral cavity and pharynx * Genetic abnormalities in lymphoid malignanciesTHOROUGHLY REVISED: * Every chapter has been meticulously reviewed and revised to incorporate the most recent research and clinical findings * Includes a valuable introduction by renowned editors Vogelstein & Kinser * Features 150 MORE illustrations than the previous edition

目次

Part 1: Basic Concepts in Cancer Genetics1. Introduction2. The Nature and Mechanisms of Human Cancer Mutation3. Genomic Imprinting and Cancer4. Genes Altered by Chromosomal Translocations in Leukemia and Lymphomas5. Chromosome Alterations in Human Solid Tumors6. Gene Amplification in Human Cancers: Biological and Clinical Significance 7. Tumor Genome Instability8. Gene Expression Profiling in CancerPart 2: Controls on Cell Cycle9. Cell Cycle Control: An Overview 10. Apoptosis and Cancer11. Oncogenes12. Tumor-Suppressor GenesPart 3: Familial Cancer Syndromes Section I. Overview 13. Familial Cancer Syndromes: Role of Caretakers and GatekeepersSection II. Defects in Caretakers14. Nucleotide Excision Repair Syndromes: Xeroderma Pigmentosum, Cockayne Syndrome, and Trichothiodystrophy15. Ataxia-Telangiectasia16. Bloom Syndrome 17. Fanconi Anemia18. Hereditary Nonpolyposis Colorectal Cancer (HNPCC)19. Werner Syndrome20. Peutz-Jeghers Syndrome21. Juvenile Polyposis SyndromeSection III. Defects in Gatekeepers 22. Retinoblastoma23. Li-Fraumeni Syndrome24. Wilms Tumor 25. Neurofibromatosis 126. Neurofibromatosis 227. Renal Carcinoma28. Multiple Endocrine Neoplasia Type 129. Multiple Endocrine Neoplasia Type 230. Malignant Melanoma31. Cowden Syndrome32. Skin Cancer (Including Nevoid Basal Cell Carcinoma Syndrome)33. Breast Cancer34. Colorectal Tumors35. Pilomatricoma and Pilomatrix Carcinoma36. Hereditary Paragangliomas of the Head and Neck37. Cylindromatosis38. Familial Cardiac Myxomas and Carney ComplexSection IV. Managing Familial Cancer Syndromes39. Genetic Testing for Familial CancerPart 4. Cancer by Site40. Pancreatic Cancer41. Ovarian Cancer42. Endometrial Cancer43. Cervical Cancer44. Bladder Cancer45. Stomach Cancer46. Prostate Cancer47. Brain Tumors48. Lung Cancer49. Hepatocellular Carcinoma50. Clinical and Biological Aspects of Neuroblastoma51. Cancers of the Oral Cavity and Pharynx52. Genetic Abnormalities in Lymphoid Mailgnancies

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