Endocrinology : an integrated approach
著者
書誌事項
Endocrinology : an integrated approach
Bios Scientific, 2001
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注記
Includes index
内容説明・目次
内容説明
Traditionally, endocrinology textbooks have been either short notes or multi-author, multi-volume monster, all of which present clinical material last and often only briefly. Endocrinology is different and used real cases to lead readers into the text and then describes the biochemistry, physiology, and anatomy they need to understand the case. The user-friendly design utilizes colour-coded boxes to highlight the basic scientific and clinical material required and also to describe the latest more advanced evidence.
Typical clinical cases are included, along with more idiosyncratic cases to capture attention and highlight the cross-disciplinary nature of medicine. Endocrinology is the first book to address the requirement for integrated basic science and clinical practice, to encourage problem-based learning, and to lead readers deep into the subject.
Unique benefits:
* integrates basics sciences and clinical practice
* features more real clinical cases than any similar book to emphasize problem-based learning
* comprehensive and yet approachable
* includes a comprehensive range of questions and answers to test understanding
目次
- THE PRINCIPLES OF ENDOCRINOLOGY
- Functions of hormones and their regulation
- Chemical signalling - endocrine, paracrine, autocrine and intracrine mechanisms
- Chemical classification of hormones and their synthesis
- Hormone synthesis
- Transport of hormones in the circulation and their half lives
- Hormone receptors - cell surface
- Hormone receptors - intracellular
- Hormones and gene transcription
- Hormone receptor regulation
- Neuroendocrine interactions
- Hormones and the immune system
- Hormones, growth promotion and malignancy
- Genes, mutations and endocrine function
- Clinical evaluation of endocrine disorders
- THE ENDOCRINE PANCREAS
- Glucose turnover
- Anabolic and catabolic phases of glucose metabolism
- Actions of insulin and glucagons
- Lipid metabolism - insulinopenia and diabetic ketosis
- Protein metabolism and the anabolic actions of insulin
- Definition and diagnosis of diabetes mellitus
- Etiology of type 1 DM
- Prevention of type 1 DM
- Structure, synthesis and metabolism of insulin and glucagons
- Anatomical features of pancreatic islets in relation to hormone secretion and its control
- Control of insulin and glucagon secretion
- Type 2 DM
- Causes of DM
- Genetic disorders of b-cell function
- Counter-regulatory hormones and DM
- Complications of DM
- Macrovascular circulatory changes
- Microvascular circulatory changes - diabetic retinopathy, nephropathy and neuropathy
- Diabetes and the neuropathic foot
- Diabetes and insulin resistance of pregnancy
- Development of the pancreas: effects of DM on organogenesis
- Treatment of DM - rationale and practical considerations
- Hypoglycemia
- Physiolocal responses to hypoglycemia and its treatment
- Hypoglycemia and insulinoma
- Hypoglycemia in infancy
- Data interpretation questions
- THE THYROID GLAND
- Iodine intake
- Anatomical features of the thyroid gland
- Iodine trapping and thyroid function
- Synthesis of thyroid hormones
- Actions of thyroid hormones
- Control of thyroid hormone synthesis and secretion
- Hyperthyroidism - Grave's disease
- Surgical anatomy and embryology of the thyroid gland
- Primary hypothyroidism - Hashimoto's disease and myxoedema
- Secondary hypothroidism
- Hypothyroidism in infancy and childhood
- Thyroid hormone resistance
- Non-thyroid illness ('sick euthyroid' syndrome)
- Transport and metabolism of thyroid hormones
- Biochemical measurements of thyroid hormone status
- Thyroid growth
- Nodular thyroid disease
- Thyroid cancer
- Data interpretation questions
- THE ADRENAL GLAND
- Specificity of the biological effects of adrenal steroid hormones
- Cholesterol and steroid synthesis in the adrenal cortex
- Anatomical and functional zonation in the adrenal cortex
- Glucocorticoid receptors
- Actions of glucocorticoids and clinical features of Cushing's syndrome
- Adrenal cortical androgens
- Hypothalamic control of adrenocortical steroid synthesis - CRH and vasopressin
- Pituitary control of adrenocortical steroids - ACTH
- Feedback control of glucocorticoids
- Excess glucocorticoids: biochemical investigation of
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