Gastrointestinal mucosal repair and experimental therapeutics
著者
書誌事項
Gastrointestinal mucosal repair and experimental therapeutics
(Frontiers of gastrointestinal research, vol. 25)
S. Karger, c2002
大学図書館所蔵 全2件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographies and index
内容説明・目次
内容説明
Over the last decade, considerable progress has been made in understanding cellular and molecular mechanisms involved in gastrointestinal mucosal injury and repair. These findings provide the basis to identify the etiology and pathogenesis of various gut mucosal injury-related diseases and to develop new therapeutic approaches. The publication at hand is divided into three sections: Epithelial restitution, mucosal repair and ulcer healing, and experimental therapeutics. The first part highlights the early rapid mucosal restitution, focussing on the roles of extracellular matrix, cytoskeleton, cytokines, Ca2+ signaling, polyamines, and the protein kinase C / DAG pathways. The next section deals with aspects of chronic mucosal healing, concentrating on the roles of primary response gene expression, angiogenesis and angiogenic growth factors, platelets, and the mechanisms of cell renewal after injury in special circumstances. The last part explores new therapeutic approaches, stressing potential clinical applications of nitric oxide-releasing agents, polysaccharides, nitric oxide synthase modulators, growth factors, prostaglandins, and cyclooxygenase inhibitors. Covering the current state-of-the-art findings relevant to gut mucosal injury and repair as well as providing the underlying conceptual basis and knowledge regarding experimental therapeutics for gastrointestinal mucosal injury-related diseases, this publication will be a timely guide for investigators working in the field.
目次
- Part 1 Epithelial Restitution: Roles of Extracellular Matrix and Cytoskeleton in Intestinal Epithelial Restitution, J.R. Turner, M.D. Basson
- Cytokines in Restitution, J. Yoo, M.M. Lotz, J.B. Matthews
- Ca2+ Signalling in Epithelial Restitution, J.N. Rao, J.-Y. Wang
- Polyamines in Intestinal Epithelial Restitution, S.A. McCormack, R.M. Ray, L.R. Johnson
- Epithelial Restitution and Physical Stress, T. Osada, S. Watanabe, N. Sato
- The Diacylglycerol/Protein Kinase C Pathway in Gastrointestinal Mucosal Injury and Defence: T.A. Miller, M.J. Redlak, L.M. Coy, M.M. Taher. Part 2 Mucosal Repair and Ulcer-Healing: Expression of Early Primary Response Genes in Healing of Gastrointestinal Mucosal Injury, J.-Y. Wang
- Role of Angiogenesis and Angiogenic Growth Factors in Mucosal Repair and Ulcer Healing, A.S. Tarnawski, M.K. Jones, D. Bataar, R. Pai
- Role of Platelets in Gastric Ulcer Healing - A Delivery System for Growth Factors, L. Ma, J.L. Wallace
- Intestinal Mucosal Function following Ischemia/Reperfusion, P. Tso, A. Wollin
- Helicobacter pylori Infection and Gastroduodenal Mucosal Damage and Healing, H.H.X. Xia, B.C.Y. Wong, S.K. Lam. Part 3 Experimental Therapeutics: Nitric Oxide-Releasing Agents - A New Generation of Drugs for Gastrointestinal Diseases, T. Brzozowski, P.C. Konturek, S.J. Konturek
- Cyclooxygenase Inhibitor, a Foe or a Friend in the Mucosal Protection and Repair, B.M. Peskar, Polysaccharides - A New Role in Gastrointestinal Protection, C.C.M. Cho, E.S.L. Liu, V.Y. Shin, C.H. Cho
- Modulators of Inducible Nitric Oxide Synthase - Potential Drugs for the Therapy of Gut Inflammation?, B.J.R. Whittle, M. Cavicchi, D. Lamarque
- Peptide and Gene Therapy with Angiogenic Growth Factors bFGF, PDGF or VEGF in Gastrointestinal Ulcers in Rats, T. Khomenko, X. Deng, H. Ishikawa, Z. Sandor, S. Szabo
- Gastrointestinal Protective Action of Prostaglandin E2 and EP Receptor Subtypes, K. Takeuchi, S. Kato, A. Tanaka.
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