Macrolide antibiotics : chemistry, biology, and practice
著者
書誌事項
Macrolide antibiotics : chemistry, biology, and practice
Academic Press, c2002
2nd ed.
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Macrolide Antibiotics: Chemistry, Biochemistry, and Practice, Second Edition explores the discovery of new macrolide antibiotics, their function, and their clinical use in diseases such as cancer, AIDS, cystic fibrosis and pneumonia. This book discusses the creation of synthetic macrolides and the mechanisms of antibiotic activity. The uses for antimicrobial macrolides in clinical practice are also covered. This book is designed to appeal to both the basic and applied research communities interested in microbiology, bacteriology, and antibiotic/antifungal research and treament.
目次
- Contributors Preface 1. Discovery of New Macrolides I. Introduction II. Macrolides from Actinomycetes III. Macrolides from Bacteria Including Myxobacteria IV. Macrolides from Fungi V. Macrolides from Plants and Lichens VI. Macrolides from Insects VII. Other Macrolides VIII. Concluding Remarks References 2. Discovery of New Macrolides from Marine Organisms I. Introduction II. Macrocyclic Lactones of Marine Organism Origin III. Concluding Remarks References 3. Chemical Modification of Macrolides I. Introduction II. Fourteen-Membered Macrolides III. Sixteen-Membered Macrolide Antibiotics and the Avermectin Family IV. Concluding Remarks References 4. Total Synthesis of Macrolides I. Introduction II. Synthetic Strategy for Macrolide Synthesis III. Total Synthesis of Selected Macrolides IV. Concluding Remarks References 5. Biosynthesis, Regulation, and Genetics of Macrolide Production I. Introduction II. Reaction Mechanism of Polyketide Biosynthesis III. Polyketide Synthase IV. Genes Encoding Modular Polyketide Synthase V. Sugar Biosynthesis VI. Genetic Manipulation of PKS Genes References 6. Pharmacokinetics and Metabolism of Macrolides I. Introduction II. Pharmacokinetics and Metabolism III. Drug Interaction IV. Concluding Remarks References 7. Antimicrobial Macrolides in Clinical Practice I. Introduction II. Fourteen- and Fifteen-Membered Macrolides III. Sixteen-Membered Macrolides IV. Concluding Remarks References 8. Ivermectin in Clinical Practice I. Introduction II. Novel Activity of Ivermectin in Clinical Practice III. Concluding Remarks References 9. Tacrolimus and Other Immunosuppressive Macrolides in Clinical Practice I. Introduction II. Tacrolimus, a Brief Developmental History III. Novel Activity of Tacrolimus and Other Immunosuppressive Macrolides in Clinical Practice IV. Concluding Remarks References 10. Mode of Action and Resistance Mechanisms of Antimicrobial Macrolides I. Introduction II. Mode of Action of Macrolide Antibiotics III. Mechanisms of Resistance to Antimicrobial Macrolides IV. Important Developments in Macrolide Antibiotics V. Concluding Remarks VI. Addendum References 11. Mode of Action of Macrolides with Motilin Agonistic Activity--Motilides I. Introduction II. Mode of Action of Motilin III. Invention of Motilides IV. BiologicalActivity of Motilides V. Clinical Trials of Motilides VI. Concluding Remarks References 12. Novel Activity of Erythromycin and Its Derivatives I. Erythromycin Treatment in Diffuse Panbronchiolitis II. Inhibition of Chloride Channel III. Effects of Macrolides on Cytokine/Chemokine Expression IV. Modulation of Bacterial Function V. New Challenge for Novel Action References 13. Mode of Action of Avermectin I. Introduction II. Target of Avermectin Action III. Cloning and Structure of Avermectin Binding Protein IV. Concluding Remarks References 14. Mode of Action of FK506 and Rapamycin I. Introduction II. Initial Cellular Target for FK506 and Rapamycin
- Peptidyl Prolylcis-trans Isomerases (Rotamases, Immunophilins) III. Target of FK506-FKBP12 Complex: Calcineurin IV. Target of Rapamycin-FKBP12 Complex: mTOR/FRAP/RFAT V. Intervention of Intracellular Signaling Pathways by FK506 and Rapamycin References Index
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