Handbook of neurotoxicology

著者

• Massaro, Edward J.

書誌事項

Handbook of neurotoxicology

edited by Edward J. Massaro

Humana, 2002

• v. 1
• v. 2

注記

Includes bibliographical references and index

内容説明・目次

巻冊次

v. 1 ISBN 9780896037953

内容説明

Neurotoxicology is a broad and burgeoning field of research. Its growth in recent years can be related, in part, to increased interest in and concern with the fact that a growing number of anthropogenic agents with neurotoxic potential, including pesticides, lead, mercury, and the polytypic bypro ducts of combustion and industrial production, continue to be spewed into and accumulate in the environment. In addition, there is great interest in natural products, including toxins, as sources of therapeutic agents. Indeed, it is well known that many natural toxins of broadly differing structure, produced or accumulated for predatory or defensive purposes, and toxic agents, accumulated incidentally by numerous species, function to perturb nervous tissue. Components of some of these toxins have been shown to be useful therapeutic agents and/or research reagents. Unfor tunately, the environmental accumulation of some neurotoxic ants of anthropogenic ori gin, especially pesticides and metals, has resulted in incidents of human poisoning, some of epidemic proportion, and high levels of morbidity and mortality. Furthermore, an increasing incidence of neurobehavioral disorders, some with baffling symptoms, is confronting clinicians. It is not clear whether this is merely the result of increased vigi lance and/or improved diagnostics or a consequence of improved health care. In any case, the role of exposure to environmental and occupational neurotoxic ants in the etiology of these phenomena, as well as neurodegenerative diseases, is coming under increasing scrutiny and investigation.

目次

I. Pesticides Marion Ehrich and Jeffrey R. Bloomquist, Section Editors Subsection A. Anticholinesterase Insecticides Acute Toxicities of Organophosphates and Carbamates Janice E. Chambers and Russell L. Carr Organophosphate-Induced Delayed Neuropathy Marion Ehrich and Bernard S. Jortner Nonesterase Actions of Anticholinesterase Insecticides Carey Pope and Jing Liu Subsection B. Pesticides that Target Ion Channels Agents Affecting Sodium Channels David M. Soderlund Agents Affecting Chloride Channels Jeffrey R. Bloomquist The Neonicotinoid Insecticides Larry P. Sheets Subsection C. Miscellaneous Pesticides with Action on the Nervous System Miscellaneous Pesticides with Action on the Nervous System Dennis Blodgett, Marion Ehrich, and Jeffrey R. Bloomquist II. Metals Tomas R. Guilarte, Section Editor Molecular Mechanisms of Low-Level Pb2+ Neurotoxicity Michelle K. Nihei and Tomas R. Guilarte Elucidation of the Zinc-Finger Motif as a Target for Heavy-Metal Perturbations Nasser H. Zawia and Morad Razmiafshari Blood-Brain Barrier and Blood-CSF Barrier in Metal-Induced Neurotoxicities Wei Zheng Manganese in Health and Disease: From Transport to Neurotoxicity Michael Aschner, James R. Connor, David C. Dorman, Elise A. Malecki, and Kent E. Vrana Aluminum Neurotoxicity Andrzej Szutowicz III. Natural Toxins of Microbial Origin David J. Adams and Daniel G. Baden, Section Editors Ecology of Microbial Neurotoxins Lyndon E. Llewellyn Biosynthesis of Important Marine Toxins of Microorganism Origins Yuzuru Shimizu Biological Assay and Detection Methods for Marine 'Shellfish' Toxins Neale R. Towers and Ian Garthwaite An Overview of Clostridial Neurotoxins MarkA. Poli and Frank J. Lebeda Molecular Mechanism of Action of Botulinal Neurotoxins and the Synaptic Remodeling They Induce In Vivo at the Skeletal Neuromuscular Junction Frederic A. Meunier, Judit Herreros, Giampietro Schiavo, Bernard Poulain, and Jordi Molgo Marine Mammals as Sentinels of Environmental Biotoxins Vera L. Trainer The Epidemiology of Human Illnesses Associated with Harmful Algal Blooms Lora E. Fleming, Lorraine Backer, and Alan Rowan IV. Natural Toxins of Animal Origin Alan Harvey, Section Editor Snake Neurotoxins that Interact with Nicotinic Acetylcholine Receptors Denis Servent and Andre Menez Presynaptic Phospholipase A2 Neurotoxins from Snake Venoms John B. Harris Dendrotoxins from Mamba Snakes J. Oliver Dolly and Giacinto Bagetta Neurotoxins from Spider Venoms Alfonso Grasso and Stefano Rufini Neurotoxins from Scorpion Venoms Marie-France Martin-Eauclaire Anthozoan Neurotoxins William R. Kem Nemertine Neurotoxins William R. Kem Secretagogue Activity of Trachynilysin, a Neurotoxic Protein Isolated from Stonefish (Synanceia trachynis) Venom Frederic A. Meunier, Gilles Ouanounou, Cesar Mattei, Pascal Chameau, Cesare Colasante, Yuri A. Ushkaryov, J. Oliver Dolly, Arnold S. Kreger, and Jordi Molgo Neurotoxins of Cone Snail Venoms Robert Newcomb and George Miljanich

巻冊次

v. 2 ISBN 9780896037960

内容説明

N eurotoxicology is a broad and burgeoning field of research. Its growth in recent years can be related, in part, to increased interest in and concern with the fact that a growing number of anthropogenic agents with neurotoxic potential, including pesticides, 1ead, mercury, and the polytypic byproducts of combustion and industrial production, continue to be spewed into and accumulate in the environment. In addition, there is great interest in natural products, including toxins, as sources of therapeutic agents. Indeed, it is well known that many natural toxins ofbroadly differing structure, produced or accumulated for predatory or defensive purposes, and toxic agents, accumulated incidentalIy by numerous species, function to perturb nervous tissue. Components of some of these toxins have been shown to be useful therapeutic agents and/or research reagents. Unfor of some neurotoxicants of anthropogenic ori tunately, the environmental accumulation gin, expecialIy pesticides and metals, has resulted in incidents ofhuman poisoning, some of epidemic proportion, and high levels of morbidity and mortality. Furthermore, an increasing incidence of neurobehavioral disorders, some with baffling symptoms, is confronting clinicians. It is not clear whether this is merely the re suit of increased vigi lance and/or improved diagnostics or a consequence of improved health care. In any case, the role of exposure to environmental and occupational neurotoxicants in the etiology of these phenomena, as well as neurodegenerative diseases, is coming under increasing scrutiny and investigation.

目次

Part I. Developmental Neurotoxicology James L. Schardein, Section Editor Developmental Neurotoxicity: Testing and Interpretation Judith W. Henck Manifestations of CNS Insult During Development Susan A. Rice Developmental Neurotoxicology: What Have We Learned from Guideline Studies? Gregg D. Cappon and Donald G. Stump Risk Assessment of Developmental Neurotoxicants Hugh A. Tilson Part II. Drugs of Abuse Patricia A. Broderick, Section Editor Electrophysiologic Evidence of Neural Injury or Adaptation in Cocaine Dependence Kenneth R. Alper, Leslie S. Prichep, E. Roy John, Sharon C. Kowalik, and Mitchell S. Rosenthal Addictive Basis of Marijuana and Cannabinoids Eliot L. Gardner Dopamine and Its Modulation of Drug-Induced Neuronal Damage Donald M. Kuhn NMDA Antagonist-Induced Neurotoxicity and Psychosis: The Dissociative Stimulation Hypothesis Kevin Noguchi Emerging Drugs of Abuse: Use Patterns and Clinical Toxicity Katherine R. Bonson and Matthew Baggott Mechanisms of Methamphetamine-Induced Neurotoxicity Jean Lud Cadet and Christie Brannock Neurotoxic Effects of Substituted Amphetamines in Rats and Mice: Challenges to the Current Dogma James P. O'Callaghan and Diane B. Miller Studies of Neural Degeneration Indicate that Fasciculus Retroflexus Is a Weak Link in Brain for Many Drugs of Abuse Gaylord Ellison Microsensors Detect Neuroadaptation by Cocaine: Serotonin Released in Motor Basal Ganglia Is Not Rhythmic with Movement Patricia A. Broderick Part III. Imaging Thomas E. Schlaepfer, Section Editor Impact of Intoxication: Structural and Functional Modifications in the Brain Induced by Ethanol Response David J. Lyons, Cory S. Freedland, and Linda J. Porrino Structural and Functional Neuroimaging of theEffects of Opioids David Nutt and Mark Daglish Structural and Functional Neuroimaging of the Effects of Cocaine in Human and Nonhuman Primates Linda J. Porrino, David J. Lyons, Sharon R. Letchworth, Cory S. Freedland, and Michael A. Nader Functional Neuroimaging of Cannabinoid Effects Godfrey D. Pearlson Neuroimaging of MDMA-Induced Neurotoxicity Una D. McCann, Zsolt Szabo, and George A. Ricaurte Part IV. Neurobehavioral Assessment Methods Joel L. Mattsson, Section Editor Tier 1 Neurological Assessment in Regulated Animal Safety Studies Joseph F. Ross. Neurological Assessment: The Role of the Clinician in Clinical Neurotoxicology James W. Albers Human Neuropsychological Testing and Evaluation Stanley Berent and Christine L. Trask

「Nielsen BookData」 より

詳細情報

• NII書誌ID(NCID): BA5813579X
• ISBN:
  • 0896037959
  • 0896037967
• 出版国コード: us
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: Totowa
• ページ数/冊数: 2 v.
• 大きさ: 26 cm