The insulinotropic gut hormone glucagon-like peptide-1
Author(s)
Bibliographic Information
The insulinotropic gut hormone glucagon-like peptide-1
（Frontiers in diabetes, vol. 13）
Karger, 1997
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Note
Includes bibliographical references and indexes
Description and Table of Contents
Description
Glucagon-like peptide-1 (GLP-1) is a promising new therapeutic tool for the treatment of diabetes. Since the first reports describing its potent insulinotropic activity were published about a decade ago, knowledge of the incretin hormones, and GLP-1 in particular, has increased significantly. This timely volume summarizes what is now known about the molecular biology, physiology and pharmacology of GLP-1. Thorough coverage is given to the physiology of the hormone, including its generation, release and actions at pancreatic and extrapancreatic tissues. The intracellular mechanisms of GLP-1 are also described in detail. Discussion of the molecular biology includes the structure and functions of the genes coding for proglucagon and the GLP-1 receptor. A special feature of the book is the clinical information provided which includes data on the expression and release of GLP-1 and its potential use as a therapeutic agent for diabetes. Presenting the results of exciting new research, this book will be a valuable reference for endocrinologists, gastroenterologists, pharmacologists, physiologists and biochemists interested in this important hormone.
Table of Contents
- Design of the entero-insular axis, W. Creutzfeldt
- proglucagon gene structure and regulation of expression, J.F. Habener
- posttranslational processing of proglucagon and postsecretory fate of proglucagon products, J.J. Holst et al
- morphological aspects of GLP-1 expression in the intestine, R. Eissele
- release of GLP-1 into the circulation, P.L. Brubaker
- GLP-1 receptor in relation to its ligand, R. Goke et al
- effects of GLP-1 on islet hormone secretion - experimental studies, H.-C. Fehmann
- in vivo regulation of human islet hormone secretion by GLP-1, D.A. D'Alessio and J.W. Ensinck
- signal transduction of GLP-1, H.-P. Bode and B. Goke
- islet genes regulated by GLP-1, H.-C. Fehmann
- GLP-1 and the glucose competence concept of pancreatic beta-cell function, G.G. Holtz and C.A. Leech
- effects of GLP-1 on gastric acid and pancreatic exocrine secretion and on gastrointestinal motility, M.A. Nauck et al
- GLP-1 in the central nervous system, R. Goke and B. Goke
- extrapancreatic action of GLP-1, B. Goke
- lessons from human studies with GLP-1 - potential of the gut hormone for clinical use, M.M. Byrne and B. Goke.
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