CiNii 図書 - Karch's pathology of drug abuse

AUTHORITATIVE INFORMATION FROM THE SOURCE YOU TRUST The third edition of Karch's Pathology of Drug Abuse continues to provide a comprehensive yet accessible guide to the pathology, toxicology, and pharmacology of commonly abused drugs. As in previous editions, the focus remains on the investigation of drug-related deaths and on practical approaches to the detection of drug abuse. It covers in detail the clinical consequences of drug usage and provides the latest information on clinical aspects of drug abuse. This well-written, extensively referenced resource supplies a mixture of clinical information and pathology findings. SEE WHAT'S NEW IN THE THIRD EDITION: New information on methamphetamine abuse New chapter on GHB, ketamine, and select herbal hallucinogens New micrographs showing pathology of drug related deaths Over 1000 new references The mechanism of sudden death in cocaine users and overdose in heroin abusers Toxicology and pathology of ephedrine Neurochemistry of excited delirium Psychotic behavior in stimulant abusers About the author: Steven B. Karch has appeared as an expert witness in international cases, including advice to counsel in the Harold Shipman murder trial. He is an assistant medical examiner in San Francisco, where he consults on cases of drug-related deaths. He received his bachelors degree from Brown University, did graduate work in cell biology and biophysics at Stanford, and received his M.D. from Tulane University Medical School.

COCAINE Incidence Epidemiology History Cultivation and Manufacture Drug Constants Routes of Ingestion Metabolism of Cocaine and Its Metabolites Problems of Test Interpretation Cocaine Tissue Disposition Cocaine's Effects on Catecholamine and the Heart External Markers of Cocaine Abuse Toxicity by Organ System When is Cocaine the Cause of Death? OTHER NATURALLY OCCURRING STIMULANTS Absinthe Caffeine Ephedrine Khat SYNTHETIC STIMULANTS Amphetamine and Methamphetamine Methylphenidate (Ritalin (TM)) Phenylpropanolamine Fenfluramine HALLUCINOGENS Phenylethylamine Derivatives Substituted Amphetamines (Phenylisopropylamines) Phenylalkylamines NARCOTICS Incidence Epidemiology Classification of Narcotic Agents History of Opiate Abuse Cultivation and Manufacture Opiate Classification Interpretation of Blood and Tissue Concentrations Medical Consequences of Opiate Abuse Pulmonary Disorders DISASSOCIATIVE ANESTHETICS Phencyclidine Ketamine Gamma-hydroxybutyrate (GHB) ANABOLIC STEROIDS Incidence Epidemiology History Steroid Abuse Pharmacology Steroid-related Disorders Detecting Steroid Abuse SOLVENTS Incidence Epidemiology General considerations Absorption and tissue disposition Clinical syndromes Appendix 1: Conversion Formulas Appendix 2: Blood Alcohol Concentrations Appendix 3: Volume of Distribution Calculations Appendix 4: Normal Heart Weights

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Karch's pathology of drug abuse

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