Proteases in biology and medicine
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Bibliographic Information
Proteases in biology and medicine
（Essays in biochemistry, v. 38）
Portland, 2002
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Note
Includes bibliographical references and index
Series editor: T.G. Cotter
Description and Table of Contents
Description
This volume aims to provide a wide-ranging overview of the many and varied roles of proteases in biological systems, to highlight some of the more recent developments in this area and to provide an insight into future research in the field of proteases. For many researchers, proteases are often considered to be unwanted biological pests. Many do their utmost to inactivate proteases in order to prevent the breakdown of their particular protein of interest. For others proteases are tools that selectively degrade a protein prior to its further analysis. However, more and more researchers are recognizing that proteases are often key players in a wide range of biological processes, such cell cycle regulation, cell growth and differentiation, antigen processing and angiogenesis. In addition, it is becoming apparent that the aberrant functionng of certain proteases may underlie several disease states, including Alzheimer's disease, cancer metastasis and inflammation. An understanding of the role played by proteases in these processes may provide the opportunity for therapeutic intervention.
Indeed, inhibitors of certain proteases have already proved to be effective therapeutic agents in hypertension and heart failure and against some forms of cancer and certain viruses.
Table of Contents
- The ubiquitin-proteasome pathway of intracellular proteolysis
- matrix metalloproteinases in cancer
- proteolytic processing of the amyloid &-protein precursor of Alzheimer's disease
- caspases
- methionine aminopeptidases and angiogenesis
- precursor convertases in the secretory pathway, cytosol and extracellular millieu
- proteases in blood clotting
- anatomy and pathology of HIV-1 protease, the "perfect" model peptidase
- inhibition of the peptidases (ACE and NEP) in control of blood pressure
- shedding of membrane proteins by ADAM family proteases
- regulated intramembrane protelysis - from the ER to the nucleus
- protease-activated receptors - the role of cell-surface proteolysis in signalling
- mining proteases in the genome databases.
by "Nielsen BookData"