Basic clinical radiobiology

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書誌事項

Basic clinical radiobiology

edited by G. Gordon Steel

Arnold, c2002

3rd ed

大学図書館所蔵 件 / 全5件

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

This concise, but comprehensive textbook sets out all the essentials of the science and clinical application of radiobiology for those seeking accreditation in radiation oncology. The fully updated 3rd edition continues to discuss the basis of radiation therapy and presents the principles and significant scientific developments that underlie current attempts to improve the radiotherapeutic managemnet of all cancers. New topics in the 3rd edition include chapters on volume effects in normal tissues and the L-Q approach in clinical practice, with major revisions to sections on cell proliferation, radiation cytogenetics, radiotherapy-related morbidity, hyperfractionation and individualisation of radiotherapy. The book continues to provide invaluable advice for trainee and practising radiation oncologists from a team of internationally respected contributors and draws on the considerable experience of the Editor, gained during his time as Course Director of the annual ESTRO course in Basic Clinical Radiobiology.

目次

Introduction: the significance of radiobiology for radiotherapy Cell proliferation and growth rate tumours Proliferative and cellular organization of normal tissues Radiation response and tolerance of normal tissues Volume effects in normal tissues Clonogenic cells and the concept of cell survival Models of radiation cell killing DNA damage and cell killing Genetic control of the cellular response to ionizing radiation Dose-response relationships in radiotherapy Radiotherapy-related morbidity Time-dose relationships: the L-Q approach The L-Q approach in clinical practice Hyperfractionation and accelerated radiotherapy The oxygen effect Modifying the tumour microenvironment The radiobiology of tumours The dose-rate effect: brachytherapy and targeted radiotherapy Particle beams in radiotherapy Combination of radiotherapy and chemotherapy Re-treatment tolerance of normal tissues Individualization of radiotherapy.

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