Innate immunity
著者
書誌事項
Innate immunity
(Infectious disease)
Humana Press, 2003
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
The concept of innate immunity refers to the first-line host defense that serves to limit infection in the early hours after exposure to microorganisms. Recent data have highlighted similarities between pathogen recognition, signaling pathways, and effector mechanisms of innate immunity in Drosophila and mammals, pointing to a common ancestry of these defenses. In addition to its role in the early phase of defense, innate immunity in mammals appears to playa key role in stimulating the subsequent clonal response of adaptive immunity. Recent exciting information has determined that the templates that are laid down in primitive life forms, like flowering plants and insects, form the basic principles of first line host defense that are conserved in mammalian systems. The next frontier in the field is to understand the dynamic adaptive changes that occur as a result of the inter play between host defenses and infectious agents. One emerging theme is that microorganisms are constantly seeking ways to co-opt host defenses. On the other hand, host defense to infection is mediated by the coordinate action of pattern recognition molecules and receptors that, in mammals, are important and probably necessary antecedents to the development of an adaptive immune response. Innate Immunity aims to explore the intersection between host pathogen interactions across an evolutionary spectrum that will inform our understanding of the dynamic interplay between infectious agents and host defense in man.
目次
Section I: Plant Immunity
Section Editor: Frederick M. Ausubel
Introduction
Frederick M. Ausubel
Pathogen Recognition and Signal Transduction in Plant Immunity
Jonathan Cohn and Gregory B. Martin
Plant Disease Resistance Genes
Jeffrey G. Ellis and David A. Jones
Nonhost Resistance in Plants to Microbial Pathogens
Michele C. Heath
Section II: Invertebrate Host Defense Immunity
Section Editor: Jean-Marc Reichhart
Introduction
Jean-Marc Reichhart
Regulatory Co-options in the Evolution of Deuterostome Immune Systems
Ellen V. Rothenberg and Eric H. Davidson
Antimicrobial Peptides in Insect Immunity
Philippe Bulet, Maurice Charlet, and Charles Hetru
Innate Immunity in the Horseshoe Crab
Shun-ichiro Kawabata, Tsukasa Osaki, and Sadaaki Iwanaga
Pattern Recognition Receptors in Drosophila
Mika Ramet, Alan Pearson, Kati Baksa, and Asha Harikrishnan
Humoral and Cellular Responses in Drosophila Innate Immunity
Julien Royet, Marie Meister, and Dominique Ferrandon
Thioester-Containing Proteins of Protostomes
Elena A. Levashina, Stephanie Blandin, Luis F. Moita, Marie Lagueux, and Fotis C. Kafatos
Section III: Mammalian Host Defenses: Pattern Recognition Receptors
Section Editor: Siamon Gordon
Introduction
Siamon Gordon
Toll-Like Receptors
Tsuneyasu Kaisho and Shizuo Akira
The Macrophage Mannose Receptor and Innate Immunity
Thiruvamoor P. Ramkumar, Djilali Hammache, and Philip D. Stahl
Diverse Roles of Lung Collectins in Pulmonary Innate Immunity
Erika C. Crouch and Jeffrey A. Whitsett
Structures of Complement Control Proteins
Thilo Stehle and Mykol Larvie
Lipopolysaccharide-Binding Protein and CD14
Peter S. Tobias
Section IV: Mammalian Host Defenses: LinksBetween Innate and Adaptive Immunity
Section Editor: Steven L. Kunkel
Introduction
Steven L. Kunkel
The Role of Chemokines in Linking Innate and Adaptive Immunity
Cory M. Hogaboam and Steven L. Kunkel
Antimicrobial Peptides
Tomas Ganz and Robert I. Lehrer
The Role of Complement in Innate and Adaptive Immunity
Mihaela Gadjeva, Admar Verschoor, and Michael C. Carroll
The Role of Natural Killer Cells in Innate Immunity to Infection
Wayne M. Yokoyama
Innate Immune Signaling During Phagocytosis
David M. Underhill
The Role of Mast Cells in Innate Immunity
Joshua A. Boyce and K. Frank Austen
CD1-Restricted T-Cells
D. Branch Moody
Index
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