Mechanistic toxicology : the molecular basis of how chemicals disrupt biological targets
著者
書誌事項
Mechanistic toxicology : the molecular basis of how chemicals disrupt biological targets
Taylor & Francis, c2003
- pbk
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Reductionism to cellular and molecular mechanisms is one of the cornerstones of modern toxicology, forming the basis for a better understanding of individual toxic effects, and providing an important tool for human risk assessment. Mechanistic Toxicology is a timely textbook that provides an introduction to this important, but often neglected, area within the toxicological sciences. This book gives new insights into the processes and mechanisms underlying the toxicity of chemicals and explains how foreign compounds (drugs, environmental pollutants, industrial chemicals) exert their potentially damaging effects on cells and tissues.
Features include:
*an extensive number of illustrations, tables and photographs
*summaries of the main learning points
*question and answer reviews at the end of each chapter
Mechanistic Toxicology incorporates recent advances in molecular biology and develops concepts for the reader in a logical way. It also illustrates, using many examples and complementary background information, how a better understanding of these mechanistic pathways helps in estimating potential risk to human health. Ideal for use in undergraduate and graduate classes of pharma-toxicology and environmental toxicology, Mechanistic Toxicology is also a valuable reference for any other readers interested in this subject.
目次
Introduction. Mechanism of Organ-Selective Toxicity. Cellular Transport and Selective Accumulation of Toxic Compounds. Bioactivation of Xenobiotics to Reactive Metabolites. Oxidative Stress: Cell Injury, Signaling, and Gene Regulation. Disruption of Calcium Homeostasis. Apoptosis and Necrosis. Perturbation of Cell Proliferation and Tissue Repair. Covalent Interactions of Reactive Metabolites with Cellular Macromolecules. Immune Mechanisms. Specific Inactivation of Enzymes. Receptor-Mediated Toxicity. Binding of Xenobiotics to Hormone-Binding Proteins. Interaction of Xenobiotics with Ion Transporters. Disruption of Cellular Energy Production and Mitochondrial Toxicity. Xenobiotic-Induced Alterations in Gene Regulation.
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