Bioassay techiques for drug development
著者
書誌事項
Bioassay techiques for drug development
Harwood Academic Publishers, c2001
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
The goal of an activity-directed isolation process is to isolate bioactive compounds which may provide structural leads of therapeutic importance. Whereas the traditional process of drug development is long and expensive, simple and rapid bioassays can serve as the starting point for drug discovery. This book presents a range of "bench top" bioassay techniques useful for natural product and pharmaceutical chemists involved in drug discovery and pharmacognosy. The contents detail a number of enzyme-based assays, cell-based functional bioassays and receptor radioligand binding assays along with detailed descriptions of each type. The majority of these bioassays are presented in a step-by-step format, so they could even be implemented by technical personnel with little background in microbiology, biochemistry or pharmacology.
目次
Part A. Bench-Top Primary Bioassay Screening. Toxicity Assays. Antimicrobial Assays. Antiviral and Anticancer Assays. Antimitotic Assay. Genotoxicity Assays. Assays for Control of Tropical Diseases. Assays for Agrochemicals. Hepatoxicity Assays. Hypoglycemic/Antidiabetic Activity Assays. Diuretic Activity Assays. Anthelminthic Assays. Anti-fertility/Anti-implantation Assay. In-vitro Assay for Platelet Aggregation. Anti-inflammatory Assay. Immunomodulating Assay. Antiepileptic (Anticonvulsant) Assay. Analgesic Assays. Gastroprotective/Antiulcer Assays. Radio-labeling Bioassays. Anti-emitic Assay. Part B. High-Throughput Screening. Enzyme Assays. Cell-based Receptor Functional Assays. Radioligand Binding Assays.
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