Oral drug absorption : prediction and assessment

著者

書誌事項

Oral drug absorption : prediction and assessment

edited by Jennifer B. Dressman, Hans Lennernäs

（Drugs and the pharmaceutical sciences, v. 106）

Marcel Dekker, c2000

大学図書館所蔵 件 / 全7件

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

A practical, hands-on guide for successfully developing oral drug products, this comprehensive reference runs the gamut from theoretical stages of computer-based calculations to practical guidelines for establishing in vitro/in vivo correlations. Coverage details the interrelationship between the physiology of the gastrointestinal tract and oral drug formulations and absorption, and progresses to the latest applications of pharmacokinetic analysis. Includes chapters by the innovators of the Biopharmaceutical Classification Scheme (BCS), human perfusions, and biorelevant dissolution testing! With over 600 literature references, equations, drawings, and photographs, Oral Drug Absorption offers multiple methods for predicting permeability, solubility, and dissolution for oral bioavailability and bioequivalence facilitates selection of appropriate drug candidates for development fully elaborates on the experimental and data analysis techniques of in vitro/in vivo correlations provides guidance to the Federal Drug Administration's BCS and its applications appends helpful case studies to the concepts discussed and much more! Contributions by more than 20 international specialists on the latest research make Oral Drug Absorption an invaluable tool and useful reference in the hands of pharmaceutical scientists, medicinal chemists, pharmacists, pharmacologists, toxicologists, biochemists, gastroenterologists, regulatory personnel, and graduate school students in these disciplines.

目次

Gastrointestinal Variables Gastrointestinal Transit and Drug Absorption Clive G. Wilson Permeability in the Gastrointestinal Tract Lars Knutson, F. Knutson, and T. Knutson Gastrointestinal Disease and Dosage Form Performance Vladan Milovic and Jurgen Stein Membrane Permeability Intestinal Permeability: Prediction from Theory Han van de Waterbeemd In Vitro Methods for the Assessment of Permeability Josef J. Tukker Animal Perfusion Studies Hans Lennernas Human Perfusion Studies Hans Lennernas The Role of Permeability Studies in Preclinical Evaluation Philip L. Smith Solubility and Drug Dissolution Solubility as a Limiting Factor to Drug Absorption Raimar Loebenberg, Michael Vieira, and Gordon L. Amidon Dissolution Testing of Immediate-Release Products and Its Application to Forecasting In Vivo Performance Jennifer B. Dressman Dissolution Tests for Extended-Release Products Barbara Sievert and Martin Siewert Dissolution Testing in the Development of Oral Drug Products Bertil Abrahamsson In Vivo-In Vitro Correlations Analysis of Drug Dissolution Data Christos Reppas and Eleftheria Nicolaides Convolution and Deconvolution Methods Richard Suverkrup The Correlation of In Vitro and In Vivo Drug Dissolution Dierk Brockmeier IVIVC: A Perspective from the Workbench Johannes Kramer

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