Protease inhibitors in AIDS therapy

著者

    • Ogden, Richard C.
    • Flexner, Charles W.

書誌事項

Protease inhibitors in AIDS therapy

edited by Richard C. Ogden, Charles W. Flexner

（Infectious disease and therapy series, v. 25）

Marcel Dekker, c2001

大学図書館所蔵 件 / 全3件

この図書・雑誌をさがす

注記

Includes bibliographical references and index

内容説明・目次

内容説明

Details the evolution of HIV protease inhibitors from molecular development through medical applications! Considering the latest class of revolutionary drugs fighting against HIV infection and AIDS, this comprehensive reference thoroughly examines the development and properties of HIV protease inhibitors from clinical and scientific perspectives, discussing how protease inhibitors changed the FDA approval process-enhancing the collaboration between regulatory authorities and drug developers. Spotlights protease inhibitors as the cornerstone drugs of the first HAART regimens-key components of long-term viral suppression and immune restoration, and in secondary and tertiary regimens! Evaluating protease inhibitors as therapeutic options and research tools, Protease Inhibitors in AIDS Therapy reviews the impact of advances in recombinant DNA technology for understanding and treating HIV and AIDS highlights a variety of strategies and techniques for drug discovery and development illustrated by success stories of pharmaceutical companies and biotechnology start-up firms summarizes the pharmacokinetics, metabolism, and drug interactions of protease inhibitors details preliminary clinical studies on oral bioavailability, pharmacokinetic profiling, efficacy, resistance, and tolerability describes available efficacy data for marketed inhibitors and those in clinical development reports on efforts to manage antiviral resistance in the clinic and improve patient adherence to complex drug therapy and more! Containing more than 600 helpful literature references, drawings, photographs, and tables, Protease Inhibitors in AIDS Therapy serves for an essential reference for infectious disease specialists, epidemiologists, virologists, immunologists, pharmacologists, medicinal chemists and biochemists, microbiologists, hematologists, hepatologists, and medical students in these disciplines.

目次

Foreword, John G. Bartlett, The Johns Hopkins University School of Medicine, Baltimore, Maryland HIV-1 Protease as a Target for AIDS Therapy, John W. Erickson Discovery and Early Development of Saquinavir, Ian B. Duncan and Sally Redshaw Discovery and Early Development of Ritonavir and ABT-378, Dale J. Kemp Discovery and Early Development of Indinavir, Bruce D. Dorsey and Joseph P. Vacca Discovery and Development of Nelfinavir (Viracept), Siegfriend H. Reich Design and Synthesis of Amprenavir, A Novel HIV Protease Inhibitor, R. D. Tung, D. J. Livingston, B. G. Rao, E. E. Kim, C. T. Baker, J. S. Boger, S. P. Chambers, D. D. Delhinger, M. Dwyer, L. Elsayed, J. Fulghum, B. Li, M. A. Murcko, M. A. Navia, P. Novak, S. Pazhanisamy, C. Stuver, and J.A. Thomson HIV Protease Inhibitors in Early Development, R. Alan Chrusciel, Judith A. Nicholas, and Suvit Thaisrivongs Pharmacology and Drug Interactions of HIV Protease Inhibitors, Charles W. Flexner Beneficial Pharmokinetic Interactions: Are Two Protease Inhibitors Better than One?, Charles W. Flexner Protease Inhibitors: Clinical Efficacy, Roy M. Gulick Toxicities and Adverse Effects of Protease Inhibitors, Marshall J. Glesby Resistance to HIV-1 Protease Inhibitors, Benjamin Young and Daniel R. Kuritzkes Expedited Drug Approval and HIV Protease Inhibitors, Jeff Murray Use of Protease Inhibitors in the Management of HIV/AIDS, Richard C. Ogden and Charles W. Flexner

「Nielsen BookData」 より

関連文献： 1件中  1-1を表示

詳細情報

ページトップへ