Renal and adrenal tumors : biology and management

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書誌事項

Renal and adrenal tumors : biology and management

edited by Arie Belldegrun, Alastair W.S. Ritchie, Robert A. Figlin, R.T.D. Oliver, Edwin Darracott Vaughan, Jr

Oxford University Press, 2002

  • hbk : alk. paper

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内容説明・目次

内容説明

In the past decade there has been an explosion of far-reaching developments in the biological and physical sciences relevant to cancer. The incidence and mortality from renal cell carcinoma has continuously risen over the past 50 years. Despite this, survival for patients has notably improved and great strides have been made in the management of patients with renal cell carcinoma. Our understanding of the natural history of renal cell carcinoma, the role of nephrectomy, the benefits of immunotherapy and the possibilities of new technologies are evolving and are being integrated with advances in classification and staging. This book provides a comprehensive source of information on renal and adrenal tumors that will be of practical interest for students, residents, physicians, and researchers alike. It reviews comprehensively the current understanding of the biology, pathophysiology and urological oncology of the disease, looking at the clinical problems and potential solutions including chapters on both the scientific and clinical principles. Fully illustrated, the book emphasises new advances in molecular biology, pathogenesis, detection and experimental therapeutics and focuses on new developments in clinical research. An international team of recognized of experts have been brought together to provide historical perspectives, an overview of basic facts, and an assessment and exploration of the newer developments in our understanding of the clinical, genetic, and molecular aspects of these diseases. The book clearly distinguishes what is generally agreed upon from what is still controversial, giving both sides equal treatment.

目次

  • ANATOMY, EPIDEMIOLOGY AND PATHOLOGY
  • 1. Historical perspective: past, present and future
  • 2. Renal and adrenal anatomy
  • 3. Diagnosis and management of the incidental renal mass
  • 4. Epithelial tumors of the kidney
  • 5. Paraneoplastic manifestations of renal cell carcinoma
  • 6. Staging of renal cell carcinoma
  • 7. Tumor markers
  • 8. Renal cell carcinoma in dialysis and transplantation
  • RENAL CELL CARCINOMA: MOLECULAR GENETICS AND IMMUNOBIOLOGY
  • 9. Basic biology and clinical behaviour of renal cell carcinoma
  • 10. Molecular cytogenics
  • 11. Hereditary/sporadic and familial RCC
  • 12. Antigens recognized by T lymphocytes on renal cell carcinoma
  • 13. Monoclonal antibodies to renal cancer antigens
  • 14. Tumour vaccines
  • 15. New approaches for biological therapy of kidney tumours: pre-clinical models and perspectives
  • 16. Pre-clinical animal models for the investigation of biological approaches for the therapy of neuroblastoma
  • 17. Angiogenesis in renal cell carcinoma
  • 18. Spontaneous regression and natural history of renal cell cancer
  • 19. Prognostic factors: localized disease
  • 20. Prognostic factors in advanced renal cell carcinoma
  • RENAL CELL CARCINOMA: IMAGING AND MANAGEMENT
  • 21. Evaluation of the renal mass and the role of biopsy
  • 22. Excretion urography imaging
  • 23. CT and MRI imaging
  • 24. Ultrasound imaging
  • 25. PET imaging
  • 26. Therapeutic options for localized disease
  • 27. Radical nephrectomy
  • 28. Inferior vena caval tumour
  • 29. Laparoscopic radical nephrectomy
  • 30. Nephron sparing surgery
  • 31. Lymph node dissection
  • 32. Follow up following surgery for renal cell carcinoma
  • 33. Adjuvant therapy of renal cell carcinoma
  • 34. Complications of surgery for renal cell carcinoma
  • RENAL CELL CARCINOMA: METASTATIC DISEASE
  • 35. Overview of immunologic therapy for renal cell carcinoma
  • 36. Natural History and prognostic factors associated with metastatic renal cell carcinoma
  • 37. Radiation therapy: basic science
  • 38. The use of systemic chemotherapy in the treatment of metastatic renal carcinoma
  • 39. Interferon for Renal Cell Carcinoma
  • 40. The role of interleukin in metastatic renal cell carcinoma
  • 41. Adoptive immunotherapy of renal cell carcinoma
  • 42. Immunotherapy for metastatic disease: the French experience
  • 43. Cell based therapy in the treatment of renal cell carcinoma
  • 44. Role of nephrectomy in metastatic disease
  • 45. Surgical resection of metastatic disease
  • 46. Gene therapy for metastatic kidney cancer
  • 47. Brain metastasis
  • 48. Palliative therapy of advanced renal cell carcinoma
  • ADRENAL TUMOURS
  • 49. Imaging of adrenal masses
  • 50. Diagnostic tests of adrenal cortical and medullary function
  • 51. Diagnosis and treatment of primary aldosteronism
  • 52. Adrenocortical carcinoma
  • 53. Pheochromocytoma
  • 54. Congenital adrenal hyperplasia
  • 55. The surgical management of congenital adrenal Hyperplasia
  • 56. Surgical options for open adrenalectomy
  • 57. Lateral transperitoneal laparoscopic adrenalectomy
  • 58. Partial adrenalectomy: indications and technique
  • 59. Acute and chronic interstitial cryotherapy of the adrenal
  • 60. Laparoscopic vs open adrenalectomy
  • 61. Selection of patients with incidentally discovered adrenal masses for operation
  • 62. Laparoscopic adrenalectomy by posterior lumbar approach

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