Two Decades of Adult T-Cell Leukemia and HTLV-I Research
著者
書誌事項
Two Decades of Adult T-Cell Leukemia and HTLV-I Research
（Gann monograph on cancer research / Japanese Cancer Association, no. 50）
Japan Scientific Societies Press , Karger, 2003
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
In April 2001, the Japanese Cancer Association was privileged to host a symposium in Kyoto to commemorate the twentieth anniversary of the discovery of the viral pathogenesis of adult T-cell leukemia (ATL). In this monograph, the editors have selected not only papers presented at the symposium but also eminent papers of several individuals from around the world who have extensively researched human T-cell-leukemia virus type I (HTLV-I), the etiological virus of ATL, over the years. During the last two decades, HTLV-I was molecularly characterized as harboring a variety of oncogenic properties in its Tax protein. Epidemiological studies not only revealed the existence of HTLV-I-endemic areas in the world, but also disclosed the routes of transmission. Despite these great strides, the mechanisms of ATL development have not yet been fully clarified, and viable therapeutic measures are still to be established. This monograph contains recent exciting achievements in molecular virology, epidemiology, immunology and therapeutic trials as well as historical profiles of HTLV-I and HTLV-I-associated diseases.
目次
- 1 General Review or Message for the Next Generation: A Synopsis on the Origin of ATLV/HTLV, Hinuma, Y.
- Human Leukemia Virus - A Godsend at Long Last, Miyoshi, I.
- Discovery of Adult T-Cell Leukemia, Reminiscences, Takatsuki, K.
- Molecular Biology of HTLV-1, Pleiotropic Function of Tax Protein in Cell Regulation, Yoshida, M.
- On the Early Period of the Discovery of Human Retroviruses and Lessons for the Future, Gallo, R.C.
- Human Receptors for Retroviruses, Weiss, R.A. 2 Molecular Pathogenesis: Molecular Mechanisms of Tax-Mediated Cell Growth of Human T Lymphocytes, Ohtani, K., Nakamura, M.
- Multiple Roles of Cellular Export Machinery in HTLV-1 Rex Functioning, Shida, H., Hakata, Y.
- Aberrant Activation of NF-kB/Rel and AP-1 in Adult T-Cell Leukemia, Mori, N., Fujii, M.
- Clastogenic and Aneugenic DNA Damage in HTLV-I Tax-Expressing Cells, Haller, K., Jeang, K.-T.
- Functional Role of the HTLV-1 p12I Protein, Johnson, J.M., Fukumoto, R., Franchini, G. 3 Mechanisms of Disease Development: Somatic Alterations in Adult T-Cell Leukemia Cells, Matsuoka, M.
- Long-Term Follow-Up of HTLV-1 Carriers, Okayama, A., Stuver, S.O.
- Molecular Pathology of HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis, Umehara, F., Osame, M.
- Genetics and Dynamics of the Immune Response to HTLV-I, Bangham, C.R.M.
- Role of HTLV-I Specific CTL in HAM/TSP, Yamano, Y., Tomaru, U., Jacobson, S. 4 Animal Disease Model: Pathogenesis of HAM/TSP in a Rat Model, Yoshiki, T.
- Autoimmune Chronic Inflammatory Arthropathy in Mice Transgenic for the HTLV-I tax Gene, Iwakura, Y.
- A Rat Model of ATL and Tumor-Vaccine, Kannagi, M., Hanabuchi, S., Ohashi, T.
- Tumorigenesis with Transgenic Expression of Human T Cell Leukemia Virus Tax, Ratner, L. 5 Prevention and Therapeutic Approach: Primary Prevention of Adult T-Cell Leukemia (ATL) in Nagasaki, Japan by Refraining from Breast- Feeding, Hino, S.
- Allogeneic Hematopoietic Stem Cell Transplantation for ATL, Ishikawa, T., Ichinohe, T., Imada, K., Uchiyama, T.
- Chemotherapy of ATL, Tobinai, K. 6 Epidemiology: Ethnoepidemiology of ATL/HTLV in Mongoloids with Special Reference to Mongoloid Dispersal, Tajima, K., Takezaki, T.
- Genetic Risk of Disease Development among HTLV-I Carriers, Sonoda, S.
- Cell-to-Cell Transmission of HTLV-I, Shiraki, H., Sagara, Y., Inoue, Y.
- Phylogenetic Analysis of HTLV-1 and STLV - The Past Movement of HTLV-1-Carriers and the Origin of PTLV, Ohkura, S. et al
- HTLV-I Worldwide Patterns and Disease Associations, Maloney, E.M., Blattner, W.A.
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