Pore-forming peptides and protein toxins
著者
書誌事項
Pore-forming peptides and protein toxins
（Cellular and molecular mechanisms of toxin action / edited by Philip Lazarovici, Vol. 5）
Taylor & Francis, 2003
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内容説明・目次
内容説明
Pore-forming proteins and peptides play a central role in bacterial pathogenesis, the immune response, defense from venomous attack, and innate immunity. These proteins attack and eliminate other organisms by punching an aqueous channel through their membranes, which disrupts appropriate cell function. The discovery of this cellular interaction has led to an abundance of scientific, medical, and commercial applications with unlimited potential.
Pore-forming Peptides and Protein Toxins describes how natural and synthetic peptides and toxins form pores and ionic channels that cause cell membrane collapse and cell death. Divided into two parts on pore-forming proteins and pore-forming peptides, each chapter reviews the normal physiological cellular structure and function, discusses the interference of toxins with this process, and considers the use of specific toxins in research. Written by researchers from around the world, the text includes such topics as the channel-forming properties of Helicobacter pylori and the role of amyloid peptide channels in the development of amyloid diseases.
This authoritative volume provides a multidisciplinary approach to understanding the basic principles and cellular mechanisms of the action of toxins and their potential use as research tools. It is an essential work for researchers and students in the fields of biochemistry, toxicology, biophysics, and pharmaceutical science.
目次
PART 1 PORE-FORMING PROTEINS. Staphylococcal Bicomponent Leucotoxins, Mechanisms of Action, Impact on Cells and Contribution to Virulence. The Formulation of Ion-permeable Channels by RTX-toxins in Lipid Bilayer Membranes: Basis for Their Biological Activity. Properties of the Monomeric and the Pentameric Pseudomonas Cytotoxin. Helicobacter pylori Vacuolating Toxin VacA: Channel-forming Properties and Cell Intoxication. Delta-endotoxin Mode of Action. Functional Studies of Helix a-5 Region from Bacillus Thuringiensis Cryl1Ab d-endotoxin. Colicin Channels and Protein Translocation: Parallels with Diphtheria Toxin. Actinoporins, Pore-forming Toxins of Sea Anemones (Actiniaria). PART 2 PORE-FORMING PEPTIDES. Structural and Change Requirements for Antimicrobial Peptide Insertion into Biological and Model Membranes. Pardaxins - Pore-forming Neurotoxins as Pharmaceutical Tools in Dissecting Neurotransmitter Exocytosis and Neurotoxicity. Cecropin-melittin Hybrid Peptides as Versatile Templates in the Development of Membrane-active Antibiotic Agents. The Syringomycins: Lipodepsipeptide Pore Formers from Plant Bacterium Pseudomonas syringae. Molecular Mechanisms of Action of Syringopeptins, Antifungal Peptides from Pseudomonas syringae pv. syringae. The Role of Amyloid Peptide Channels in Amyloid Disease.
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