Tumor prevention and genetics
著者
書誌事項
Tumor prevention and genetics
（Recent results in cancer research, 163,
Springer, 2003-2005
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注記
Includes bibliographical references and index
3: Indexed in current contents and index medicus
内容説明・目次
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3 ISBN 9783540222286
内容説明
Identification of cancer risk factors and potential prevention strategies have been some of the most important medical and research contributions to the improvement of public health in the past half-century (Steele 2003). Und- standing the role of lifestyle, exposure to endogenous factors and exogenous environmental factors, and individual genetic and epigenetic variability have contributed significantly to this effort. Cancer prevention strategies have been developed based on results of epidemiologic, preclinical, and clinical studies that have generated clues for identifying risk factors that may be modulated by changes in lifestyle, such as smoking cessation or dietary modification (Greenwald 2002a). In addition, significant progress in medical interventions involving chemoprevention-a pharmacological approach to intervention that aims to prevent, arrest, or reverse either the initiation phase of carcinogenesis or the progression of premalignant cells-is beg- ning to pay dividends in reducing risks associated with cancer.
Emerging technologies, identification of biomarkers of risk, and advances in genetics research also are finding applications in chemoprevention research that p- mise to speed the acquisition of knowledge on the molecular and cellular - fects of chemopreventive agents. 2 Lifestyle Approaches Population studies from the 1950s through the early 1980s provided c- pelling evidence that modifiable lifestyle choices can either increase or - crease cancer risk. For example, several landmark epidemiologic studies in the 1950s showed a clear association between smoking and lung cancer (Wynder and Graham 1950; Levin et al. 1950). In 1964, the U. S.
目次
- Lifestyle and Medical Approaches to Cancer Prevention.- Application of Genetics to the Prevention of Colorectal Cancer.- Genetics and Prevention of Oesophageal Adenocarcinoma.- Preclinical Models Relevant to Diet, Exercise, and Cancer Risk.- Individualizing Interventions for Cancer Prevention.- Can Animal Models Help Us Select Specific Compounds for Cancer Prevention Trials?.- Problems with Using Biomarkers as Surrogate End Points for Cancer: A Cautionary Tale.- Can a Marker Be a Surrogate for Development of Cancer, and Would We Know It if It Exists?.- How Should We Move the Field of Chemopreventive Agent Development Forward in a Productive Manner?.- The Problems with Risk Selection
- Scientific and Psychosocial Aspects.- Chemoprevention of Lung Cancer.- Anti-nicotine Vaccination: Where Are We?.- Primary Prevention of Colorectal Cancer: Lifestyle, Nutrition, Exercise.- Chemoprevention of Colorectal Cancer: Ready for Routine Use?.- Screening of Colorectal Cancer: Progress and Problems.- The Role of Endogenous Hormones in the Etiology and Prevention of Breast Cancer: The Epidemiological Evidence.- Innovative Agents in Cancer Prevention.- The IARC Commitment to Cancer Prevention: The Example of Papillomavirus and Cervical Cancer.- Health Economics in the Genomic Age.- Screening for Cancer: Are Resources Being Used Wisely?.
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[1] ISBN 9783540440628
内容説明
This book presents a comprehensive update of the latest findings in oncogenetics. It also investigates the relevance of preclinical models with respect to clinical cancer prevention (primary and secondary) for major cancer types such as breast, skin, lung, prostate and colon cancer. All contributions have been written by internationally recognised experts in the field.
目次
From the contents: Genetic susceptibility, predicting risk and preventing cancer.- Novel approaches to identify low penetrance cancer susceptibility genes using mouse models.- Development of novel selective cell ablation in the mammary gland and brain to study cell-cell interactions and chemoprevention.- Mouse skin as a model for cancer chemoprevention by nonsteroidal anti-inflammatory drugs.- Preclinical models for chemoprevention of colon cancer.- New cancer biomarkers deriving from the NCI early detection research.- Tamoxifen's impact as a preventive agent in clinical practice.- Aromatase inhibitors in prevention.- HRT opposed to low dose Tamoxifen.- Is mammography screening for breast cancer really not justifiable?- How reliable is the evidence for screening mammography.- Breast cancer screening policies around the world.- Skin cancer chemoprevention.- Chemoprevention of non-melanoma skin cancer.- Chemoprevention of lung cancer.- Key issues in lung cancer chemoprevention trials of new agents.
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