Cox-2 : a new target for cancer prevention and treatment
著者
書誌事項
Cox-2 : a new target for cancer prevention and treatment
（Progress in experimental tumor research, vol. 37）
Karger, c2003
大学図書館所蔵 全9件
注記
Includes bibliographical references and indexes
内容説明・目次
内容説明
Numerous investigators have found increased levels of cyclooxygenase-2 (COX-2) in both pre-malignant and malignant tissues. Moreover, animals engineered to be COX-2 deficient or treated with a selective COX-2 inhibitor showed reduced tumor formation and growth. The present book reviews these findings suggesting that COX-2 is a valid molecular target for the prevention and treatment of cancer. The first chapters are devoted to the epidemiology of nonsteroidal anti-inflammatory drugs (NSAIDs) and cancer, the pharmacology of COX-2 inhibitors and the regulation of COX-2 expression in human cancers. Besides, the book contains a series of chapters examining the link between COX-2 and cancer in specific organs (e.g. skin, breast, cervix, digestive tract, lung, etc.). Furthermore, several clinical trials assessing the potential of COX-2 inhibitors for preventing and treating cancer are described. The final chapter provides an up-to-date consideration of COX-independent targets of NSAIDs and related compounds in cancer prevention and treatment. This state-of-the-art publication is recommended reading not only for medical and radiation oncologists, but also for pharmacologists, gastroenterologists and other subspecialists.
目次
- Epidemiology of Non-Steroidal Anti-Inflammatory Drugs and Cancer, Baron, J.A.
- Pharmacology of COX-2 Inhibitors, Isakson, P.C.
- Regulation of COX-2 Expression in Human Cancers, Dixon, D.A.
- Cyclooxygenase-2 and Skin Carcinogenesis, Furstenberger, G., Marks, F., M ller-Decker, K.
- The Role of COX-2 in Breast and Cervical Cancer, Dannenberg, A.J., Howe, L.R.
- Cyclooxygenase-2, A Target for the Prevention and Treatment of Cancers of the Upper Digestive Tract, Altorki, N.K., Subbaramaiah, K., Dannenberg, A.J.
- Cyclooxygenase-2 and Colorectal Cancer, DuBois, R.N.
- Cyclooxygenase-2 in Lung Cancer, Dubinett, S.M., Sharma, S., Huang, M., Dohadwala, M., Pold, M., Mao, J.T.
- COX-2 Inhibitors and Other NSAIDs in Bladder and Prostate Cancer, Sabichi, A.L., Lippman, S.M.
- Therapeutic Potential of Selective Cyclooxygenase-2 Inhibitors in the Management of Tumor Angiogenesis, Gately, S., Kerbel, R.
- Potential for Combined Modality Therapy of Cyclooxygenase Inhibitors and Radiation, Saha, D., Choy, H.
- Non-Steroidal Anti-Inflammatory and Cyclooxygenase-2-Selective Inhibitors in Clinical Cancer Prevention Trials, Hawk, E.T., Viner, J.L., Umar, A.
- Chemotherapy with Cyclooxygenase-2 Inhibitors in the Treatment of Malignant Disease, Pre-Clinical Rationale and Preliminary Results of Clinical Trials, Blanke, C.D., Masferrer, J.L.
- Role of COX-Independent Targets of NSAIDs and Related Compounds in Cancer Prevention and Treatment, Soh, J.-W., Weinstein, I.B.
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