Cholinesterases and cholinesterase inhibitors
著者
書誌事項
Cholinesterases and cholinesterase inhibitors
Martin Dunitz, 2000
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
With the collaboration of the most distinguished scholars in this field Professor Giacobini has put together a publication which will convey present knowledge in the field of molecular biology and genetics, biochemistry, cell biology, pharmacology and toxicology as well of clinical applications (particularly in the field of Alzheimer's disease therapy) of cholinesterase inhibitors. In a concise but precise manner it condenses our present knowledge of these enzymes and their inhibitors and helps those who want to understand them as well as to utilize them for therapeutic purposes.
目次
1. Introduction 2. Cholinesterase Inhibitors: An Introduction 3. Molecular Structure of Cholinesterases and Complexes with Inhibitors 4. Rational Design of Cholinesterase Inhibitors 5. Genetics and Epigenetics of Mammalian Cholinesterases 6. The Gene Structure of Cholinesterases 7. Molecular Forms and Anchoring of Cholinesterases 8. Mechanism of Action of Anticholinesterase Agents 9. Distribution and Localization of Cholinesterases in the Human Brain 10. Measurement of Cholinesterase Activity 11. Preclinical Studies of the Effect of Cholinesterase Inhibitors 12. Synaptic, Behavioural and Toxicological Effects of Cholinesterase Inhibitors in Animals and Humans 13. Use of Cholinesterase Inhibitors in Alzheimer Therapy 14. Cholinesterase Inhibitors Do More Than Inhibit Cholinesterases 15. The Effect of Cholinesterase Inhibitors Studied with Brain Imaging 16. Use of Cholinesterase Inhibitors in The Therapy of Myasthenia Gravis
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