Biological reaction engineering : dynamic modelling fundamentals with simulation examples
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Bibliographic Information
Biological reaction engineering : dynamic modelling fundamentals with simulation examples
Wiley-VCH, 2003
2nd, completely rev. ed
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Previous ed.: 1992
Includes index
Description and Table of Contents
Description
Here, the modeling of dynamic biological engineering processes is presented in a highly understandable way using a unique combination of simplified fundamental theory and direct hands-on computer simulation. Throughout, the mathematics is kept to a minimum, yet the 60 simulation examples supplied on a CD-ROM with this second edition illustrate almost every aspect of biological engineering science. Many of the examples are taken from the authors' own research, and each is described in detail, including the model equations. The programs are written in the modern user-friendly simulation language Berkeley Madonna, which runs on both Windows PC and Power-Macintosh computers.Madonna solves models comprising many ordinary differential equations using very simple programming, yet is so powerful that the model parameters may be defined as "sliders", which allow the effect of their change on the model behavior to be seen almost immediately. Users may include data for curve fitting, and perform sensitivity or multiple runs. The results can be seen simultaneously on multiple-graph windows or by using overlays resulting in a tremendous learning effect.
The authors' extensive experience, both in university teaching and international courses, is reflected in this well-balanced presentation, which is suitable for teachers, students, biochemists and engineers. The result is a greater understanding of the formulation and use of mass balances and kinetics for biological reaction engineering, written in a most stimulating manner.
Table of Contents
Preface.PART I: PRINCIPLES OF BIOREACTOR MODELLING.1. MODELLING PRINCIPLES.Fundamentals of Modelling.Development and Meaning of Dynamic Differential Balances.Formulation of Balance Equations.2. BASIC BIOREACTOR CONCEPTS.Information for Bioreactor Modelling.Bioreactor Operation.3. BIOLOGICAL KINETICS.Enzyme Kinetics.Simple Microbial Kinetics.Structured Kinetic Models.4. BIOREACTOR MODELLING.General Balances for Tank-type Biological Reactors.Modelling Tubular Plug Flow Bioreactors.5. MASS TRANSFER.Mass Transfer in Biological Reactors.Interphase Gas-Liquid Mass Transfer.General Oxygen Balances for Gas-Liquid Transfer. Models for Oxygen Transfer in Large Scale Bioreactors6. DIFFUSION AND BIOLOGICAL REACTION IN IMMOBILIZED BIOCATALYST SYSTEMS.External Mass Transfer.Internal Diffusion and Reaction within Biocatalysts.7. AUTOMATIC BIOPROCESS CONTROL FUNDAMENTALS.Elements of Feedback Control.Types of Controller Action.Controller Tuning.Advanced Control Strategies Concepts for Bioprocess Control.REFERENCES.PART II: DYNAMIC BIOPROCESS SIMULATION EXAMPLES AND THE BERKELEY MADONNA SIMULATION LANGUAGE.8. SIMULATION EXAMPLES OF BIOLOGICAL REACTION PROCESSES USING BERKELEY MADONNA.Introductory Examples.Batch Reactors.Fed Batch Reactors.Continuous Reactors.Oxygen Uptake Systems.Controlled Reactors.Diffusion Systems.Multi-Organism Systems.Membrane and Cell Retention Reactors.9. APPENDIX: USING THE BERKELEY MADONNA LANGUAGE.10. ALPHABETICAL LIST OF EXAMPLES.11. INDEX.
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