Synthetic DNA delivery systems
著者
書誌事項
Synthetic DNA delivery systems
（Biotechnology intelligence unit, 7）
Landes Bioscience, c2003
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
DNA delivery into cells is a rapidly developing area in gene therapy and biotechnology. Moreover, it is a powerful research tool to determine gene structure, regulation, and function.
Viral methods of DNA delivery are well-characterized and efficient, but little is known about the toxicity and immunogenecity of viral vectors. As a result, non-viral, transfection methods of DNA delivery are of increasing interest.
Synthetic DNA Delivery Systems is a comprehensive and current resource on DNA transfection. The use of histidine-rich peptides and polypeptides as DNA delivery systems and self-assembled delivery systems based on cationic lipids and polymers are discussed. Targeted delivery to organelles, tumor cells and dendritic cells comprise an important topic.
目次
- I: Introduction
- D. Luo, W.M. Saltzman. II: Overcoming Cellular Barriers along the DNA Delivery Pathway. Outside of the cell: Supramolar assemblies of DNA delivery systems
- Pitard. At the cell surface: Engineering the surface properties of synthetic gene delivery systems
- Schaffer. Inside of the cell: Histidine containing peptides and polypeptides as nucleic acid vectors
- Midoux. Intracellular targets for DNA delivery: nuclei and mitochondria
- Torchilin. III: Targeted DNA Delivery. Immune cells: Mannose receptor-mediated gene delivery into antigen presenting dendritic cells
- Zenke. Muscle: Electro-gene-transfer: a new approach for muscle gene delivery
- Toniatti. Tumor: Tumor-targeted gene transfer with DNA polyplexes
- Wagner. IV: Novel DNA Delivery Systems. Light: Photochemical transfection: a technology for efficient light directed gene delivery
- Hogset. Ultrasound: Sonoportation: mechanical DNA delivery by ultrasonic cavitation
- Miller, Greenleaf.
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