Endotoxins : pyrogens, LAL testing, and depyrogenation

著者

• Williams, Kevin L.
• Weary, Marlys
• Jorgensen, James H.

書誌事項

Endotoxins : pyrogens, LAL testing, and depyrogenation

Kevin L. Williams ; with contributions by Karen Roberts, N. Anthony Nnalue

（Drugs and the pharmaceutical sciences, v. 111）

Marcel Dekker, c2001

2nd ed., rev. and expanded

注記

1st ed. was published as Pyrogens: endotoxins and LAL testing and depyrogenation, by F. C. Pearson

Includes bibliographical references and index

内容説明・目次

内容説明

"Describes the environmental presence, detection, properties, and biological structure and function of endotoxins in parenteral manufacturing. Includes assay development, automation, depyrogenation, and regulation of testing by Limulus amebocyte lysate (LAL) methods. Provides expanded coverage of the emergence of nonmicrobial host active bacterial products."

目次

• Historical foundations of pyrogen research
• pyrogen, endotoxin, and fever - an overview
• endotoxin structure, function, activity
• the host response to endotoxin
• non-endotoxin microbial pyrogens (lesser endotoxins and superantigens)
• non-microbial exogenous pyrogens and drug fever
• pharmaceutical manufacturing contamination control
• endotoxin as a standard
• the rabbit pyrogen test
• LAL discovery, mechanism, and application
• LAL assay development, validation and regulation.

「Nielsen BookData」 より

詳細情報

• NII書誌ID(NCID): BA64655954
• ISBN:
  • 0824793625
• LCCN: 2002275620
• 出版国コード: us
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: New York
• ページ数/冊数: x, 372 p.
• 大きさ: 24 cm.
• 分類:
  • LCC : QP632.E4
  • DC21 : 616/.01
• 件名:
  • LCSH : Endotoxins -- Analysis
  • LCSH : Pyrogens -- Analysis
  • LCSH : Limulus test
  • LCSH : Drugs -- Microbiology
  • MESH : Endotoxins -- analysis
  • MESH : Infusions, Parenteral -- standards
  • MESH : Limulus Test
  • MESH : Pyrogens -- analysis
• 親書誌ID:
  • BA03948165