Aldo-keto reductases and toxicant metabolism
著者
書誌事項
Aldo-keto reductases and toxicant metabolism
（ACS symposium series, 865）
American Chemical Society, c2004
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注記
"Sponsored by the ACS Division of Chemical Toxicology."
Includes bibliographical references and index
内容説明・目次
内容説明
Aldo-Keto Reductases and Toxicant Metabolism provides an overview of the rapidly growing Aldo-Keto Reductase (AKR) superfamily and its role in the metabolism of endogenous and exogenous toxicants. This book discusses the ability of AKRs to metabolize endogenous toxicants including: sugar aldehydes, advanced glycosylation end products, and lipid aldehydes (products of lipid peroxidation decomposition).
The relevance to diabetic complications is also stressed. The role of AKRs to metabolize exogenous toxicants including tobacco carcinogens (tobacco specific nitrosamine ketones and trans-dihydrodiols derived from polycyclic aromatic hydrocarbons), mycotoxins (aflatoxin dialdehydes), and unnatural aldehydes is covered in detail. In the case of PAH trans-dihydrodiols, a clear example is given that AKRs may not always be chemoprotective; in this instance, reactive and redox-active
quinones are formed. What emerges is that AKRs play a central role in toxicant metabolism.
Aldo-Keto Reductases and Toxicant Metabolism shows how evolutionary AKRs are conserved in prokaryotes through eukaroytes and can thus be considered primordial genes. They are also regulated by primordial stress signals (osmotic stress, reactive oxygen species, and electrophiles) to respond to toxic insult. The role of AKRs to respond to stress in vivo is given in a model of myocardial ischemia and re-perfusion injury. The power of functional yeast genomics is described to generate AKR
null yeast strains and a resultant phenotype.
目次
- SECTION 1: GENERAL OVERVIEW
- 1. Introduction and Overview of the Aldo-Keto Reductase (AKR) Superfamily
- SECTION 2: AKRS AND ENDOGENOUS TOXICANTS
- 2. Aldo-Keto Reductase-Catalyzed Detoxication of Endogenous Aldehydes Associated With Diabetic Complications
- 3. Aldose Reductase Detoxifies Lipid Aldehydes and Their Glutathione Conjugates
- 4. Role of Aldose Reductase in the Detoxification of Oxidized Phospholipids
- SECTION 3: AKRS AND EXOGENOUS TOXICANTS: TOBACCO RELATED CARCINOGENS
- 5. Competing Roles of Reductases in the Detoxification of the Tobacco-Specific Nitrosamine Ketone NNK
- 6. Aldo-Keto Reductases and the Metabolic Activation of Polycyclic Aromatic Hydrocarbons
- 7. Molecular Cloning and Characterization of Dihydrodiol Dehydrogenase from Mouse
- 8 Efficient Synthesis of the Active Metabolites of Carcinogenic Polycyclic Aromatic Hydrocarbons
- 9. Chemistry of PAH o-Quinones Generated by the AKR Pathway of PAH Activation
- 10. Analysis of Etheno-2'-Deoxyguanosine Adducts as Dosimeters of AKR Mediated Oxidative Stress
- SECTION 4: AKRS AND EXOGENOUS TOXICANTS: MYCOTOXINS, ALDEHYDES AND KETONES
- 11. Aflatoxin Aldehyde Reductases
- 12. Competing Reactions of Aflatoxin B1-Dialdehyde: Enzymatic Reduction vs Adduction with Lysine
- 13. The use of mammalian cell lines to investigate the role of aldo-keto reductases in the detoxication of aldehydes and ketones
- SECTION 5: AKRS, THE STRESS RESPONSE AND CELL SIGNALING
- 14. Aldose Reductase and the Stress Response
- 15. Aldose Reductase Regulates Reactive Oxygen Species Mediated-Inflammatory Signals
- 16. Aldo-Keto Reductases in the Stress Response of the Budding Yeast Saccharomyces cerevisiae
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