Immunology and infectious disease
著者
書誌事項
Immunology and infectious disease
(Molecular and cellular biology of critical care medicine / Robert S. B. Clark and Joseph A. Carcillo, 3)
Kluwer Academic Pub., c2003
大学図書館所蔵 全4件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
Individualized dosing regimens specific to the patient, infection, bacteria, and antibiotic can optimize outcome. Integration of pharmacokinetic and pharmacodynamic data, called dual individualization, can be accomplished through the use of AUIe. AUIC dosing has been shown to predict bacteriological outcomes, hasten clinical outcomes, reduce the emergence of resistance, and be cost-effective. MPC dosing has been shown to predict the emergence of resistant submutants. AUIC and MPC information can provide guidance as to when low doses can be used, and when higher concentrations are required. This strategy can ensure efficacy, minimize toxicity, reduce the opportunity for resistance to occur, and save money. REFERENCES I. Paladino JA. Streamlining antibiotic therapy: clinical application of pharmacokinetic and pharmacodynamic principles. J Osteopath Med 1991; 5: 16-25. 2. Liss RH, Batchelor FR. Economic evaluations of antibiotic use and resistance - a perspective: report of task force 6. Rev Infect Dis 1987; 9 (suppI3): S297-312. 3. Holmberg SO, Solomon SL, Blake PA. Health and economic impacts of antimicrobial resistance. Rev Infect Dis 1987; 9: 1065-78. 4. Sanders cc.
Mechanisms responsible for cross-resistance and dichotomous resistance among the quinolones. Clin Infect Dis 2001; 32(Suppl I ):S 1-8. 5. Ballow CH, Schentag 11. Trends in antibiotic utilization and bacterial resistance: report of the NNRSG. Diagn Microbiol Infect Dis. 1992; 15(suppl):37S-42S. 6. Rice LB, Eckstein EC, DeVente J, Shlaes OM. Ceftazidime-resistant Klebsiella pneumoniae isolates recovered at the Cleveland Department of Veterans Affairs Medical Center. Clin Infect Dis 1996; 23: 118-24.
目次
- List of Contributors. 1. Host Microbicidal Actions of the Innate Immune Response
- S.M. Opal, R. Yap. 2. Activation of the Innate Immune Response in Critical Illness
- A. Oberholzer, et al. 3. Down-Regulation of the Immune Response
- A. Ayala, et al. 4. Mechanisms of Pharmacologic Immune Supression
- B.D. Kahan. 5. Modulation of the Immune Response in Critical Illness/Injury
- L.A. Doughty. Immune Monitoring and Strategies for Immune Modulation
- H.-D. Volk, et al. 7. Central Venous Catheter Related Infections: The Role of Antimicrobial Catheters
- I. Chatzinikolaou, I.I. Raad. 8. Discrimination of True Lower Respiratory Tract Infection in the Mechanically Ventilated Patient
- R.G. Wunderink, G.W. Waterer. 9. Detection of Urinary Tract Infection in the Catheterized ICU Patient
- P.A. Tambyah, D.G. Maki. Antimicrobial Choices and Dosing Strategies to Maximize Efficacy and Minimize the Development of Bacterial Resistance
- J.A. Paladino.
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