Biochemistry of pulmonary emphysema

著者

    • Grassi, Carlo

書誌事項

Biochemistry of pulmonary emphysema

edited by C. Grassi ... [et al.]

Springer-Verlag , Bi & Gi, c1992

  • gw
  • us
  • it

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内容説明・目次

内容説明

Pulmonary emphysema is a disease which develops because of a localized imbalance between endogenous proteinase inhibitors and proteinases leaking from neurophils during phagocytosis at inflammatory foci within the lung. This volume not only reviews at a biochemical level what is known about the natural inhibitors and proteinases involved in connective tissue destruction within the lung, but also suggests novel methodologies for re-establishing proper enzyme-inhibitor balance, including the use of natural or synthetic inhibitors for supplementation or gene therapy.

目次

  • Pulmonary emphysema - what's going on
  • elastin and the lung
  • an introduction to the endopeptidases
  • lung proteinase and emphysema
  • multiple functions of neutrophil proteinases and their inhibitor complexes
  • kinetics of the interaction of human leucocyte elastase with protein substrates
  • proteinase inhibitor candidates for therapy of enzyme-inhibitor imbalances
  • antileucoprotease (secretory leucocyte proteinase inhibitor), a major proteinase inhibitor in the human lung
  • development and evaluation of antiproteases as drugs for preventing emphysema
  • genetic control of human alpha-1-antitrypson and hepatic gene therapy
  • neutrophils, neutrophil elastase and the fragile lung.

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