Hydrolysis in drug and prodrug metabolism : chemistry, biochemistry, and enzymology

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書誌事項

Hydrolysis in drug and prodrug metabolism : chemistry, biochemistry, and enzymology

Bernard Testa, Joachim M. Mayer

Wiley-VCH, c2003

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

Many drugs and other xenobiotics (e.g., preservatives, insecticides, and plastifiers) contain hydrolyzable moieties such as ester or amide groups. In biological media, such foreign compounds are, therefore, important substrates for hydrolytic reactions catalyzed by hydrolases or proceeding non-enzymatically. Despite their significance, until now, no book has been dedicated to hydrolysis and hydrolases in the metabolism of drugs and other xenobiotics. This work fills a gap in the literature and reviews metabolic reactions of hydrolysis and hydarion from the point of views of enzymes, substrates, and reactions.

目次

Chapter 1. Introduction: Metabolic Hydrolysis and Prodrug Design. Chapter 2. Classification, Localization, and Some Physiological Roles of Hydrolytic Enzymes. Chapter 3. Catalytic Mechanisms of Hydrolytic Enzymes. Chapter 4. The Hydrolysis of Amides. Chapter 5. The Hydrolysis of Lactams. Chapter 6. The Hydrolysis of Peptides. Chapter 7. The Hydrolysis of Carboxylic Acid Esters. Chapter 8. The Hydrolysis of Carboxylic Acid Ester Prodrugs. Chapter 9. The Cleavage of Esters of Inorganic Acids. Chapter 10. The Hydration of Epoxides. Chapter 11. Miscellaneous Reactions of Hydration and Dehydration. Chapter 12. Conclusion: The Biochemistry of Water. Index.

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