Targets for cancer chemotherapy : transcription factors and other nuclear proteins

著者

    • La Thangue, Nicholas B.
    • Bandara, Lasantha R.

書誌事項

Targets for cancer chemotherapy : transcription factors and other nuclear proteins

edited by Nicholas B. La Thangue and Lasantha R. Bandara

（Cancer drug discovery and development）

Humana Press, c2002

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

In Targets for Cancer Chemotherapy: Transcription Factors and Other Nuclear Proteins, a panel of leading basic researchers, pharmaceutical scientists, and clinical oncologists explain in detail the therapeutically-relevant protein targets that contribute to cancer pathology and spell out their implications for cancer drug discovery and clinical application. The authors identify and illuminate selected transcription factor oncoproteins and tumor suppressors, together with nuclear proteins that are central to the phenotype of the tumor cell involved in chromatin control. The emphasis is on new targets and approaches to cancer treatment derived from the cancer cell cycle, gene control targets, and angiogenesis.

目次

Cancer Chemotherapy Based on E2F and the Retinoblastoma Pathway William G. Kaelin, Jr Myc Oncoproteins as Targets for Therapeutic Intervention in Tumorigenesis Bernd Berwanger and Martin Eilers The AP-1 Family of Transcription Factors: Structure, Regulation, and Functional Analysis in Mice Marina Schorpp-Kistner, Peter Herrlich, and Peter Angel Hypoxia-Induced Factor-1 as a Target for Anticancer Therapy Shoumo Bhattacharya Nuclear b-Catenin Signaling as a Target for Anticancer Drug Development Eun Joo Chung, Paolo Bonvini, Ho Jung Oh, Len Neckers, and Jane Trepel Histone Acetyltransferases as Potential Targets for Cancer Therapies Stuart Thomson and Louis C. Mahadevan Histone Deacetylases Manfred Jung Cyclin-Dependent Kinases and Their Small-Molecule Inhibitors in Cancer Therapy R. Nagaraja Rao and Bharvin K. R. Patel Mitogen-Activated Protein Kinase Cascades as Therapeutic Targets in Cancer Antonio Chiloeches and Richard Marais Mdm2 and ARF Andrea Klotzbucher and Michael H. G. Kubbutat The Breast Cancer Susceptibility Genes, BRCA1 and BRCA2 Anastasia Gabriel and Alan Ashworth Human Papillomavirus: Targets for Therapeutic Intervention David Pim, Miranda Thomas, and Lawrence Banks Apoptin as an Anticancer Therapy Mathieu H. M. Noteborn E2F and Cancer Chemotherapy Debabrata Banerjee and Joseph R. Bertino Hypoxic Signaling Pathways as Targets for Anticancer Therapy Heidi M. Sowter and Adrian L. Harris Androgen Receptor and Estrogen Receptors H. M. Oosterkamp and R. Bernards

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