Calcium channel pharmacology

著者

    • McDonough, Stefan I.

書誌事項

Calcium channel pharmacology

edited by Stefan I. McDonough

Kluwer Academic/Plenum Publishers, c2004

大学図書館所蔵 件 / 全9件

この図書・雑誌をさがす

注記

Includes bibliographical references and index

内容説明・目次

内容説明

Voltage-gated calcium channels are critical regulators of cytoplasmic levels of calcium, the universal signaling ion. As such, calcium channels trigger a wide range of cellular functions, from muscle contraction to neurotransmitter secretion, and are important players in human disease. Prominent in the nervous, cardiovascular, and endocrine systems, members of the calcium channel family are targets for existing antihypertensive and anticonvulsant drugs. In addition, they are emerging targets for drugs to treat an extraordinarily diverse group of disorders, including pain, cerebral ischemia, cardiac arrhythmia, and migraine. This book reviews the compounds that target individual calcium channel subtypes and the cellular and behavioral functions governed by each different channel. It contains information for basic scientists using calcium channel antagonists as experimental tools, for behavioralists studying animal models of human disease, and for pharmaceutical scientists interested in creating the next generation of calcium channel-targeted drugs. Several factors make an entire book on calcium channel pharmacology timely.

目次

  • Introduction
  • S.I. McDonough. Concepts of State-Dependent Pharmacology of Calcium Channels
  • E.N. Timin, S. Berjukow, S. Hering. Pharmacology of Cav1 (L-Type) Channels
  • D.J. Triggle. The Therapeutic Utility of Targeting Cav2 Channels
  • C.J. Cohen, R.L. Kraus. Peptide Toxin Inhibition of Voltage Gated Calcium Channels: Selectivity and Mechanisms
  • S.I. McDonough. Calcium Channel Blocking Polypeptides: Structure, Function, and Molecular Mimicry
  • R.S. Norton, J.B. Baell, J.A. Angus. Pharmacology of Cav 3 (T-Type) Channels
  • E.A. Ertel. Cellular Functions of Calcium Channel Subtypes
  • E.S. Piedras-Renteria, P.G. Mermelstein, G.S. Pitt. Genetic Approaches to the Elucidation of Calcium Channel Functions in Vivo
  • H. Saegusa, T. Tanabe. Calcium Channel Mutations and Associated Diseases
  • Y. Mori, Y. Itsukaichi, M. Nishida, H. Oka. Modulation of High Voltage-Activated Calcium Channels by G Protein-Coupled Receptors
  • A.M. Beedle, G.W. Zamponi. Alternative Splicing in Voltage Gated Calcium Channels
  • D. Lipscombe, A.J. Castiglioni. Index.

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