Clinical nephrotoxins : renal injury from drugs and chemicals
Author(s)
Bibliographic Information
Clinical nephrotoxins : renal injury from drugs and chemicals
Kluwer Academic Publishers, c2003
2nd ed
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Note
Includes index
Description and Table of Contents
Description
This is a comprehensive handbook on all aspects of adverse effects by drugs, chemical substances and radiation on the kidneys. The book consists of a general part dealing with themes such as clinical relevance, renal handling and cellular mechanisms of nephrotoxicity, as well as animal and cell culture models. The second part includes the specific drugs, for instance the anti-infectious agents, anti-inflammatory drugs, cardiovascular drugs, anti-cancer drugs and so forth. The last part deals with the prevention consisting of urinary biomarkers, pharmacological aspects and drug dosage in renal failure. In this second and completely revised edition, several new topics were added, information regarding the paediatric age group was expanded and up-to-date references provided, while remaining true to the concept of a multinational author book.
Table of Contents
1. Clinical relevance. 2. Renal handling of drugs and xenobiotics. 3. Pharmacovigilance. 4. Immunologically-mediated toxin-induced renal disease. 5. Cellular mechanisms of nephrotoxicity. 6. Animal models for the assessment of acute renal dysfunction and injury. 7. Renal cell culture models. 8. Aminoglycosides and vancomycin. 9. Beta-lactam antibiotics. 10. Amphotericin B. 11. Sulfonamides, sulfadiazine, trimethoprim-sulfamethoxazole, pentamidine, pyrimethamine, dapsone, quinolones. 12. Antiviral agents. 13. Analgesics and 5-aminosalicylic acid. 14. Non-steroidal anti-inflammatory drugs. 15. Gold salts, D-penicillamine and allopurinol. 16. Angiotensin I converting enzyme inhibitors and angiotensin II receptor antagonists. 17. Diuretics. 18. Anticancer drugs. 19. Anesthetic agents. 20. Illicit drug abuse. 21. Cysclosporine, tacrolimus and sirolimus. 22. Immunomodulators: interleukins, interferons, and the OKT3 monoclonal antibody. 23. Radiocontrast agents. 24. Lead nephropathy. 25. Cadmium nephropathy. 26. Mercury nephropathy. 27. Exposure to hydrocarbons, silicon-containing compounds and pesticides. 28. Lithium nephropathy. 29. Aristolochic acid nephropathy after Chinese herb remedies. 30. Balkan endemic nephropathy. 31. Nephrotoxins in Africa. 32. Paraphenylene diamine hair dye poisoning. 33. Urinary biomarkers and nephrotoxicity. 34. Pharmacological aspects of nephrotoxicity. 35. Principles of drug usage in dialysis patients.
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