Molecular biology in medicinal chemistry

著者

• Dingermann, Theodor
• Steinhilber, Dieter
• Folkers, Gerd

書誌事項

Molecular biology in medicinal chemistry

edited by Th. Dingermann, D. Steinhilber and G. Folkers

（Methods and principles in medicinal chemistry / edited by R. Mannhold ... [et al.], vol.21）

Wiley-VCH, 2004

注記

Includes bibliographical references and index

内容説明・目次

内容説明

This readily comprehensible book explains the identification of molecular targets via cellular assays, reporter genes or transgenic models, as well as surveying recent advances in the synthesis, separation and analysis of drugs. A special section is devoted to molecular genetics methods. With its examination of these novel methods and generous practical advice, this is essential reading for all pharmaceutical chemists, molecular biologists and medical researchers using molecular methods to study drugs and their action.

目次

MOLECULAR TARGETS Cellular Assays in Drug Discovery Gene Knockout Models Reporter Gene Assay Systems for the Investigation of GPCRs From the Human Genome to New Drugs: The Potential of Orphan GPCRs SYNTHESIS Stereoselective Synthesis with the Help of Recombinant Enzymes Nucleic Acid Drugs ANALYSIS Recent Trends in Enantioseparation of Chiral Drugs Affinity Chromatography NMR-based Drug Discovery 13C- and 15N-Isotopic Labeling of Proteins Antibody Fragments as Crystallization Enhancers KINETICS, METABOLISM AND TOXICOLOGY Pharmacogenetics: The Effect of Inherited Genetic Variation on Drug Disposition and Drug Response Pharmacogenomics of Bioavaliability and Elimination Toxicogenomics: Integration of New Molecular Biological Tools in Toxicology

「Nielsen BookData」 より

詳細情報

• NII書誌ID(NCID): BA65911561
• ISBN:
  • 3527304312
• 出版国コード: us
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: Weinheim
• ページ数/冊数: xxi, 413 p.
• 大きさ: 25 cm
• 親書誌ID:
  • BA22871556