Biology of negative strand RNA viruses : the power of reverse genetics
Author(s)
Bibliographic Information
Biology of negative strand RNA viruses : the power of reverse genetics
（Current topics in microbiology and immunology, 283）
Springer, c2004
- hbk.
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Note
Includes index
Description and Table of Contents
Description
Negative-strand RNA viruses, so named because of the polarity of their genomic RNA to mRNA, include important human and non-human pathogens. This volume covers major advances in reverse genetics techniques over the past decade, state-of-the-art basic science and the clinical implications of experimental findings. This should rekindle interest in negative-strand RNA viruses among readers, including those in other disciplines, leading to further progress in understanding these important viruses and in developing effective measures of control.
Table of Contents
Introduction.- Reverse genetics of mononegavirales.- Reverse systems for the generation of segmented negative-sense RNA viruses entirely from cloned cDNA.- Transcription and replication of non-segmented negative strand RNA viruses.- Orthomyxovirus replication, transcription, and polyadenylation.- Escaping from the cell: assembly and budding of negative-strand RNA viruses.- Accessory genes of the paramyxoviridae, a large family of nonsegmented negative strand RNA viruses, as a focus of active investigation by reverse genetics.- Identification and characterization of viral antagonists of type I interferon in negative-strand RNA viruses.- Towards multivalent vaccines and therapeutic viruses.- Influenza vaccines generated by reverse genetics.- Subject index
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