T cell subsets : cellular selection, commitment and identity
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Bibliographic Information
T cell subsets : cellular selection, commitment and identity
(Advances in immunology / edited by W.H. Taliaferro and J.H. Humphrey, v. 83)
Elsevier Academic Press, c2004
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T-cell subsets
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Includes bibliographical references and index
Description and Table of Contents
Description
This first thematic issue, of the Advances in Immunology series, highlights the remarkable new insights into the mechanisms that govern development and function of T cell lineages. Recent developments in the understanding of the genetic and epigenetic mechanisms that regulate development of the two major T cell lineages will have a fundamental impact on a number of research fields -immunology, cell biology, hematology and stem cell research. All of these groups have a vested interest in comprehending issues such as stem cell self renewal, progenitor plasticity, lineage commitment and cellular identity. Immunologists have a special interest in the mechanisms that allow selection of a T cell repertoire whose members integrate genetic information for T cell receptor, co-receptor and specialized immunologic function, since this process lies at the core of adaptive immunity.T Cell Subsets is a timely and invaluable review for immunologists, cell biologists hematologists and stem cell researchers
Table of Contents
Early Lymphoid Progenitor Subsets - Lineage Commitment and Developmental Plasticity
The CD4/CD8 Lineage Choice: New Insights
Analysis of the CD4/CD8 Lineage Decision
Development and Function of T Helper 1 Cells
Th2 cells: Orchestrating Barrier Immunity
Memory T. Cells -Generation, Maintenance, and Function
An Integrated Model of Immunoregulation
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