Hot topics in infection and immunity in children

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書誌事項

Hot topics in infection and immunity in children

edited by Andrew J. Pollard, George H. McCracken, Jr. and Adam Finn

（Advances in experimental medicine and biology, v. 549, 568, 582, 609, 634, 659, 697, 719, 764）

Kluwer Academic/Plenum Publishers, c2004-

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注記

Vol. 2-4 edited by Andrew J. Pollard and Adam Finn

Vol. 5-9 edited by Adam Finn and Nigel Curtis and Andrew J. Pollard

Publisher of v. 2-9: Springer

"In association with the British Paediatric Allergy, Immunity and Infection Group (BPAIIG), the European Society for Paediatric Infectious Diseases (ESPID), and the Department of Paediatrics, University of Oxford.''--T.p. of v. 2

Includes bibliographical references and index

内容説明・目次

巻冊次

[1] ISBN 9780306483448

内容説明

Hot Topics in Infection and Immunity in Children brings together leading experts in the field to provide a current and authoritative view concerning the hottest topics of concern to clinicians caring for children with infections and research scientists working in the areas of infectious disease, immunology, microbiology and public health. The book is based on a collection of manuscripts from a faculty of authors of international standing who contributed to a course in Paediatric Infection and Immunity in Oxford, UK in June 2003.

目次

1. Of Vaccination and Infectious Diseases in 2003.- 2. New Antibiotics and Bacterial Resistance.- 3. New Antivirals and Antiviral Resistance.- 4. Mucosal Immunity to Infections and its Importance in Future Vaccinology.- 5. Dynamics of Bacterial Carriage and Disease: Lessons from the Meningococcus.- 6. Current Management of Bacterial Meningitis.- 7. Congenital Syphilis Resurgent.- 8. Antibiotics for Acute Otitis Media in the Era of Antibiotic Resistance-What are the Choices?.- 9. Bone and Joint Infections in Children.- 10. Sepsis Syndrome in Children: Can We Do Better?.- 11. Prevention of Enteric Diseases.- 12. Viral Hepatitis in Children.- 13. Controversies in Neonatal Infection.- 14. Bacterial and Fungal Infections in the Neonate: Current Diagnosis and Therapy.- 15. Pertussis is Back and Now What?.- 16. The Immunocompromised Host: The Patient with Recurrent Infection.- 17. Febrile Neutropenia: Past, Present, and Future.- 18. Malaria.- 19. HIV-1 Infection in Children: Current Practice and Future Predictions.- 20. Preventing Perinatal Transmission of HIV-Are We Doing Enough?.- 21. Congenital Cytomegalovirus Infection: Epidemiology and Treatment.- 22. Global Control of Rotavirus Disease.- 23. RSV and Influenza.- 24. Encephalitis-Beyond Aciclovir.- 25. Current Issues in Managing Group A Streptococcal Infections.- 26. Kawasaki Disease and Toxic Shock Syndrome-At Last the Etiology is Clear?.- 27. The Last of the Meningococcus?.- 28. The Potential of Pneumococcal Conjugate Vaccines to Reduce Antibiotic Resistance.- 29. Is Haemophilus influenzae Type b Disease Finished?.- 30. Strategies for Preventing Group B Streptococcal Disease.- 31. Recent Advances in the Therapy Against Invasive Aspergillosis.
巻冊次

2 ISBN 9780387253411

内容説明

Hot Topics in Infection and Immunity II provides a current view from leading experts concerning the hottest topics of concern to clinicians caring for children with infections. The book brings together a collection of manuscripts from a faculty of authors of international standing who contributed to a course in Paediatric Infection and Immunity in Oxford, UK in June 2004.

目次

Emerging Infections and Children: Influenza and Acute Necrotizing Encephalopathy.- Chickenpox Party or Varicella Vaccine?.- The ABC of Epstein-Barr Virus Infections.- The Immune Response to Viral Lower Respiratory Tract Infection.- Chronic Granulomatous Disease: From Genetic Defect to Clinical Presentation.- Novel Primary Immunodeficiencies.- Periodic Fever.- BCG Vaccine.- Helminth Infections of Children: Prospects for Control.- Rabies on the Doorstep.- Prevention of Typhoid Fever.- Dexamethasone in the Treatment of Pediatric Bacterial Meningitis in Developing Countries: Is it Beneficial?.- Should Dexamethasone be Part of Routine Therapy of Bacterial Meningitis in Industrialised Countries?.- How to Interpret a CSF-The Art and the Science.- Reverse Vaccinology and Vaccines for Serogroup B Neisseria meningitidis.
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3 ISBN 9780387317830

内容説明

This volume covers topics in infectious diseases in children and is intended for Pediatric Infectious Disease trainees, trainers, and all those who manage children with infections. There is a balance of clinical basic science. In response to numerous requests, additional tropical topics are covered in some depth. As in previous volumes, the emphasis is on hot topics of clinical relevance delivered by world class speakers.

目次

Warfare and the State of the World's Children.- How Do We Treat Children with Severe Malaria?.- The Neglected Tropical Diseases: The Ancient Afflictions of Stigma and Poverty and the Prospects for their Control and Elimination.- Viral Haemorrhagic Fevers Caused by Lassa, Ebola and Marburg Viruses.- Rotavirus and Rotavirus Vaccines.- Transient Deficiencies of T-Cell-Mediated Immunity in the Neonate.- Controversies in Neonatal Sepsis: Immunomodulation in the Treatment and Prevention of Neonatal Sepsis.- Chlamydia trachomatis Genital Infection in Adolescents and Young Adults.- The Role of Inflammation and Infection in the Development of Chronic Lung Disease of Prematurity.- Streptococcus pneumoniae: Infection, Inflammation and Disease.- Impact of Antimicrobial Resistance on Therapy of Bacterial Pneumonia in Children.- Diagnosis and Prevention of Pneumococcal Disease.- New Antibiotics for Gram-Positive Infections.- Clinical Manifestations of Nontuberculous Mycobacteria.- Kingella kingae: An Emerging Pediatric Pathogen.- How to Treat Acute Musculoskeletal Infections in Children.- Prevention of Transmission of HIV-1 from Mothers to Infants in Africa.- Practical Aspects of Antiretroviral Treatment in Children.- Antibiotic Treatment for Acute Otitis Media in Children.- Antibiotic Prophylaxis for the Prevention of Recurrent Urinary Tract Infections in Children.- Human Metapneumovirus: An Important Cause of Acute Respiratory Illness.
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4 ISBN 9780387739595

内容説明

Fast becoming a key text for pediatricians, this fourth outing for the Hot Topics series is once again culled from lectures given at the annual course on the subject at Keble College, Oxford. This is the first port of call for those who need to keep on top of the subject. With world-leading researchers as editors, the series has become a valuable addition to the sum of knowledge in this specialism and a resource for anyone dealing with infectious diseases in children.

目次

Contributing Authors.- The Enteroviruses: an Emerging Infectious Disease? The Real, the Speculative...and the Really Speculative.- Mark J. Abzug.- Introduction.- Enterovirus 71: a "New" Neurologic Threat.- Modern Epidemiology and Clinical Presentations.- EV71 Brainstem Encephalitis.- EV71 Acute Flaccid Paralysis.- EV71 Diagnosis.- EV71 Pathogenesis.- EV71 History and the Emergence of Severe Epidemic Disease.- Therapy of EV71 Infection.- Congenital EV Infection.- Previous Evidence of In Utero EV Infection.- New Evidence for Congenital EV Infection: Amniotic Fluid Studies.- New Evidence for Congenital EV Infection: Placental Studies.- New Evidence of Congenital EV Infection: What Does it Mean?.- Chronic Fatigue Syndrome.- Evidence implicating EVs: the European Experience.- Evidence from Europe Not Implicating EVs.- New Evidence Implicating EVs: the American Experience.- Evidence Linking EV Infection and CFS: Possible Explanations.- Conclusions.- References.- Science and Society: The HIV Epidemic and South African Political Responses.- Hoosen M. Coovadia and Imraan Coovadia.- Introduction.- South Africa: The AIDS Advisory Committee.- Sarafina.- The Virodene Saga.- The Presidential AIDS Advisory Panel (Mbeki Panel, 2001).- The Durban Declaration.- The Enigma of President Mbeki.- Pragmatism.- Preoccupation with Governance.- The Politics of Negotiation.- AIDS and the Global Context.- Conclusion.- References.- Pathogenesis of Group A Streptococcal Infections and Their Sequelae.- Madeleine W. Cunningham.- Introduction.- Virulence Determinants and the Host Response.- Acute Rheumatic Fever.- 3.1 Immune Mechanisms in Rheumatic Carditis.- 3.1.1 Antibody Reacts with Valve Endothelium.- 3.1.2 T cell Infiltration through Valve Endothelium.- 3.1.3 Immune Mechanisms in Sydenham's Chorea.- Post-Streptococcal Glomerulonephritis.- Acknowledgements.- References.- 4. Snakes, Jellyfish and Spiders.- Bart J. Currie.- Introduction.- Toxins and clinical relevance.- Snakebite.- Jellyfish stings.- Spider bites.- Conclusions.- Acknowledgements.- References.- Current Status of Group A Streptococcal Vaccine Development.- James B. Dale.- Introduction.- Burden of Disease Caused by GAS Infections.- Current Strategies for Vaccine Development.- Rationale for M Protein-Based GAS Vaccines.- Preclinical Evaluation of a 26-Valent M Protein-Based Vaccine.- Clinical Experience with the 26-Valent GAS Vaccine.- Development of Vaccines Designed to Prevent Rheumatic Fever.- Summary and Conclusions.- Acknowledgements.- References.- New Aspects on Diagnosis and Transmission of Hepatitis B in Paediatric Patients and Pregnant Women.- Robert A. de Man, Annemiek van der Eijck and Irene Veldhuijzen.- Horizontal transmission of hepatitis B and the paediatric patient.- Infectivity of body fluids.- Implications for the paediatric patient.- Chronic hepatitis B in pregnancy.- References.- Pertussis Immunisation in Adolescents and Adults.- Ulrich Heininger.- Introduction.- Epidemiology.- 2.1 Incidence of pertussis disease compared to B. pertussis.- infections in adolescents and adults.- 2.2 Adolescents and adults as the source for pertussis in infants.- Disease.- Diagnosis.-Treatment.- Prevention by Immunisation.- Successful Childhood Programmes.- Expanding Programmes Beyond Childhood.- Summary.- References.- 8. Trachoma: Recent Developments.- David Mabey.- Introduction.- Epidemiology.- Trachoma assessment.- Clinical signs and C. trachomatis infection.- Pathogenesis of Trachoma.- The SAFE strategy.- Surgery.- Antibiotic.- References.- 9. Gonococcal Infections in Newborns and in Adolescents.- Noni MacDonald, Tim Mailman, Shalini Desai.- 1. Introduction.- 2. The Microbe.- 3. Gonococcal Infection in Newborns.- 4. Gonococcal Ophthalmia Neonatorum.- 5. Neonatal Gonococcal Scalp Abscess and Disseminated Gonococcal Infection.- 6. Diagnosis of Neonatal Gonococcal Infections.- 7. Treatment of Neonatal Gonococcal Infections.- 8. Prevention of Neonatal Gonococcal Infection.- 9. Gonococcal Infection in Adolescents.- 10. Why are Adolescents STI Rates so high?.- 11. Partners, Condom Use and Sexual Networks.- 12. Clinical Presentations of Gonococcal Infection in Adolescents.- 13. Diagnosis Testing for N gonorrhoea Infections in Adolescents.- 14. Treatment pf Adolescent Gonococcal Infections.- 15. Prevention of Gonococcal Infections in Adolescents.- 16. Summary.- References.- 10. Management of Severe Dengue in Children.- Christopher Moxon and Bridget Wills.- 1. Introduction.- 2. Clinical features of severe dengue infection in children.- 3. Pathogenesis.- 4. Management - theoretical considerations.- 5. Management - practical guidelines.- 5.1 Fluid resuscitation.- 5.2 Management of bleeding.- 6. Summary/Conclusion.- References.- 11. Human Papillomavirus Vaccines: Who should get them and why?.- Stephane Paulus and Simon Dobson.- 1. Introduction.- 2. HPV epidemiology.- 3. Cervical cancer epidemiology.- 4. Age of sexual debut.- 5. Education/school leaving.- 6. HPV vaccines: nature and characteristics of immunising agent.- 7. Vaccine Safety.- 8. HPV vaccine implementation.- References.- 12. Antimicrobial Resistance Among Enteric Pathogens.- Larry K. Pickering.- 1. Introduction.- 2. Advantages of antimicrobial therapy.- 3. Limitations and challenges of antimicrobial therapy.- 4. Reasons for mechanisms of resistance.- 5. Resistance patterns of enteric pathogens.- 5.1 Campylobacter jejuni/coli.- 5.2 Shigella species.- 5.3 Salmonella species.- 6. Effect of resistance on clinical manifestations and treatment options.- 7. Future directions.- References.- 13. What the paediatrician needs to know when pandemic influenza arrives in clinical practice.- Nicole Ritz and Nigel Curtis.- 1. Introduction.- 1.1 The media outbreak.- 2. The impact of pandemic influenza.- 2.1 How many people will be affected?.- 2.2 How fast will pandemic influenza spread?.- 2.3 Is human-to-human transmission likely to occur?.- 3. Diagnosis and clinical features of H5N1 avian influenza.- 3.1 Differences between pandemic influenza and seasonal influenza.- 3.2 Clinical features.- 3.2.1 Clinical features at presentation.- 3.2.2 Presentation with delayed respiratory features.- 3.2.3 Complications.- 3.3 Radiology.- 3.4 Laboratory features.- 3.4.1 Routine investigations.- 3.4.2 Laboratory confirmation.- 4. The treatment of H5N1 avian influenza.- 4.1 Adamantanes (M2 blockers).- 4.2 Neuraminidase inhibitors.- 4.2.1 Mechanism of action.- 4.2.2 Administration.- 4.2.3 Formulations.- 4.2.4 Effectiveness.- 4.2.5 Adverse effects.- 4.2.6 Dosing in children.- 4.3 Resistance to anti-influenza drugs.- 4.4 Prophylaxis.- 4.5 Who should be treated?.- 4.6 Additional and other treatments.- 4.7 Personal stockpiling of antiviral drugs.- 5. Limiting the spread of influenza during a pandemic.- 6. The prevention of pandemic influenza.- 7. Conclusion.- Acknowledgements.- References.- 14. Lyme Disease.- Eugene D. Shapiro.- 1. Introduction.- 1.1 Etiology and Epidemiology.- 2. Clinical Manifestations.- 3. Diagnosis.- 4. Treatment.- 5. "Chronic" Lyme Disease.- 6. Congenital Lyme Disease.- 7. Prevention of Lime Disease.- 8. Lyme Hysteria.- 9. Summary.- References.- 15. Management of Myocarditis in Children: the current situation.- Brigitte Stiller.- 1. Introduction.- 2. Viral Myocarditis: three different phases.- 2.1 Phase 1: Viral Infection.- 2.2 Phase 2: Autoimmune Injury.- 2.2.1 T cells.- 2.2.2 Cytokines.- 2.3 Phase 3: Dilated Cardiomyopathy.- 3. Diagnosis and Treatment of the Different Phases: Current Recommendations.- Phase 1: Diagnosis and Treatment in Viral Replication.- Phase 2: Diagnosis and Treatment during Autoimmune Activation.- Phase 3: Diagnosis and Treatment during Dilative Cardiomyopathy.- 4. Clinicopathological Subtypes of Myocarditis.- 4.1 Fulminant myocarditis.- 4.2 Acute myocarditis.- 4.3 Chronic active myocarditis.- 4.4 Chronic persistent myocarditis.- 5. Therapeutic Strategies for Paediatric heart Failure and Haemodynamic Instability.- 6. Conclusions.- References.- 16. Therapy of Herpes Virus Infections in Children.- Richard J. Whitley.- 1. Introduction.- 2. Neonatal Herpes Simplex Virus Infection.- 3. Activiral Therapy of neonatal HSV Infection.- 3.1 Mortality.- 3.2 Morbidity.- 3.2.1 Disseminated and CNS Neonatal HSV Disease.- 3.2.2 Skin Eye and Mouth Disease.- 3.2.3 Summary.- 4. Herpes Simplex Encephalitis.- 4.1 Treatment.- 5. Varicella Zoster Virus.- 5.1 Treatment of Varicella in the Immunocompetent Host.- 5.2 Treatment of Varicella in the Immunocompromise Host.- 5.3 Valacyclovir and Famciclovir.- 5.4 Resistant Varicella Zoster Virus Infections.- 6. Cytomegalovirus.- 6.1 Diagnosis.- 6.2 Treatment.- 7. Summary.- References.
巻冊次

5 ISBN 9780387798370

内容説明

Course covers topics in infectious diseases in children and is intended for Pediatric Infectious disease trainees, trainers, and all those who manage children with infections. This conference is being supported by several societies and is sponsored by several pharmaceutical companies, such as Aventis, Baxter, Chiron Vaccines, Wyeth, etc.

目次

Shiga-Toxin Producing Escherichia coli and the Hemolytic Uremic Syndrome: What Have We Learned in the Past 25 Years?.- Global Epidemiology of Pneumococcal Disease-New Prospects for Vaccine Control.- Current Concepts of the Pathogenesis of RSV Bronchiolitis.- How Can We Eradicate Pertussis.- Recognition and Management of Encephalitis in Children.- Microbiology and Management of Pleural Empyema.- Pneumococcal Conjugate Vaccines Probe Studies: The Solution Points to the Problem.- New Findings in Primary Immunodeficiency.- Routine Use of Influenza Vaccine.- Challenges in the Evaluation and Management of Bone and Joint Infections and the Role of New Antibiotics for Gram Positive Infections.- The Significance of Serotype Replacement for Pneumococcal Disease and Antibiotic Resistance.- Childhood Intra-thoracic Tuberculosis.- The Antibiotic Pipeline in Pediatrics.- Paediatric Drug Development and Clinical Trials.- Influenza in Pregnancy: The Case for Prevention.- Febrile Neutropenia in Children with Cancer.- The PANDAS Syndrome.- Fever in the Returned Paediatric Traveller.- Molecular Diagnostics of Primary Immunodeficiencies: Benefits and Future Challenges.- Human Genetic Resistance to Malaria.
巻冊次

6 ISBN 9781441909800

内容説明

Course covers topics in infectious diseases in children and is intended for Pediatric Infectious disease trainees, trainers, and all those who manage children with infections. Each of the chapters in this book is based on a lecture given at the sixth "Infection and Immunity in Children" course, held at the end of June 2008 at Keble College, Oxford. Thus, it is the sixth book in a series that provides succinct and readable updates on just about every aspect of the discipline of Pediatric Infectious Diseases.

目次

Infections in the Immunocompromised.- Host Biomarkers and Paediatric Infectious Diseases: From Molecular Profiles to Clinical Application.- The Epidemiology and Management of Non Typhoidal Salmonella Infections.- Where does Campylobacter Come From? A molecular odyssey.- Why Are Some Babies Still Being Infected With HIV in the U.K.?- The Use and Abuse of Antibiotics and the Development of Antibiotic Resistance.- Vaccination against Varicella: What's the Point?- What Can We Learn from the Retina in Severe Malaria?. Epidemiology and Prevention of Neonatal Candidiasis: Fluconazole for all Neonates?- Current Status of Treatment of Hepatitis B in Children.- Treatment of Neonatal Fungal Infections.- Malaria in Pregnancy and the Newborn.- Adenovirus Infection in the Immunocompromised Host.- Strategies for Global Prevention of Hepatitis B Virus Infection.
巻冊次

7 ISBN 9781441971845

内容説明

Course covers topics in infectious diseases in children and is intended for Pediatric Infectious disease trainees, trainers, and all those who manage children with infections.
巻冊次

8 ISBN 9781461402039

内容説明

Book covers course with topics in infectious diseases in children and is intended for Pediatric Infectious disease clinical researchers, trainees, trainers, and all those who manage the research of children with infections and the children themselves. The conference is being supported by several societies and is sponsored by several pharmaceutical companies, such as Aventis, Baxter, Chiron Vaccines, Wyeth, etc. ToC reflects the scientific program found here: http://www.oxfordiic.org/#course

目次

Our time of pestilence: purchasing immunity and ignoring the misery of others.- Neonatal meningitis: can we do better?.- Approaches towards avoiding lifelong antiretrovial therapy in paediatric HIV infection.- How short is long enough for treatment of bone and joint infection?.- What's new in diagnostic testing and treatment approaches for Mycoplasma pneumoniae infections in children?.- Pigs, poultry, and pandemic influenza: how zoonotic pathogens threaten human health.- Kingella kingae infections in children: an update.- Influenza pandemics.- Management of shunt related infections.- Nontuberculous lymphadenopathy in children: using the evidence to plan optimal management.- Pediatric brucellosis: an (almost) forgotten disease.- Q fever: still more queries than answers.- Rickettsioses in children: a clinical approach.- What is the evidence behind recommendations for infection control?.- What do we know about how to treat tuberculosis?.- Bacterial meningitis in childhood.- Mycobacterium marinum infection.
巻冊次

9 ISBN 9781461447252

内容説明

Hot Topics in Infection and Immunity IX

目次

Innovation for the 'bottom 100 million': eliminating neglected tropical diseases in the Americas.- Non-typhoidal Salmonella in children: microbiology, epidemiology and treatment.- Invasive fungal infections in patients with chronic granulomatous disease.- Clostridium difficile in children: a review of existing and recently uncovered evidence.- Diarrhea among children in developing countries.- Building confidence in vaccines.- Chronic recurrent multifocal osteomyelitis.- Recognition and treatment of chlamydial infections from birth to adolescence.- Treatment of resistant bacterial infections in children: thinking inside and outside the box.- An encephalitis primer.- The evidence behind prophylaxis and treatment of wound infection after surgery.- Infectious risks associated with biologics.- Cat scratch disease and other Bartonella infections.- When to think of Immunodeficiency?.- Mycetoma by Madurella mycetomatis: A completely neglected medico-social dilemma.- Elucidation and clinical role of emerging viral respiratory tract infections in children.- Urinary tract infections in children: microbial virulence versus host susceptibility.- Preventing urinary tract infections in early childhood.- How to get and get rid of gonorrhoea.- Management of severe malaria: results from recent trials. When to think of Immunodeficiency?.- Mycetoma by Madurella mycetomatis: A completely neglected medico-social dilemma.- Elucidation and clinical role of emerging viral respiratory tract infections in children.- Urinary tract infections in children: microbial virulence versus host susceptibility.- Preventing urinary tract infections in early childhood.- How to get and get rid of gonorrhoea.- Management of severe malaria: results from recent trials.

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