The chemistry of 1,2,3-Thiadiazoles

著者

• Bakulev, Vasiliy A.
• Dehaen, Wim.

書誌事項

The chemistry of 1,2,3-Thiadiazoles

Vasiliy A. Bakulev, Wim Dehaen

（The chemistry of heterocyclic compounds : a series of monographs, v. 62）

J. Wiley, c2004

注記

Includes bibliographical references and index

内容説明・目次

内容説明

1,2,3-Thiadiazoles are a group of heterocycles whose derivatives are important in industry, medicine, and agriculture. This volume provides a complete treatment of this group of heterocycles with an emphasis on syntheses, structural data, properties, reactions, and applications.

目次

1 Synthesis of 1,2,3-thiadiazoles. 1.1 Cyclization of Hydrazones with Thionyl Chloride (Hurd-Mori Synthesis). 1.1.1 Scope and Limitations. 1.1.2 Mechanism of the Hurd-Mori Reaction. 1.1.3 Application of the Hurd-Mori Reaction in Organic Synthesis. 1.2 Cycloaddition of Diazoalkanes onto a C=S bond (Pechmann Synthesis). 1.3 Heterocyclization of -diazo Thiocarbonyl Compounds (Wolff Synthesis). 1.3.1 Introduction of a Diazo Function into Compounds Containing a C=S Bond. 1.3.2 Introduction of a C=S Bond in the -position to a Diazo Group. 1.3.3 Simultaneous Introduction of Diazo and Thiocarbonyl Functions. 1.4 Transformations of other Sulfur-containing Heterocyclic Compounds. 1.5 Elaboration of Preformed 1,2,3-Thiadiazoles. 1.5.1 Carboxylic Acids. 1.5.2 Functional Derivatives of Carboxylic Acids. 1.5.3 Aldehydes. 1.5.4 Amino-1,2,3-Thiadiazoles. 1.5.5 Halo Derivatives. 1.5.6 5-Hydrazino-, 5-Mercapto-1,2,3-Thiadiazoles and 5-Sulfide Derivatives. 1.5.7 2-(1,2,3-Thiadiazol-5-yl)acetic Acid Derivatives. 1.5.8 Alkenyl-1,2,3-Thiadiazoles. 1.5.9 5-Hydroxyiminomethyl- and 5-Diazomethyl-1,2,3-Thiadiazoles. 1.5.10 4-Hydroxymethyl-1,2,3-Thiadiazoles. 1.6 Tables. 1.7 Selected Procedures. 1.7.1 1,2,3-Thiadiazole-4-Carbaldehyde. 1.7.2 4-Phenyl-1,2,3-Thiadiazole. 1.7.3 4-Phenyl-1,2,3-Thiadiazole-5-Carbaldehyde. 1.7.4 4-Phenyl-5-Oxyiminomethyl-1,2,3-Thiadiazole. 1.7.5 5-Phenyl-1,2,3-Thiadiazole-4-Carbaldehyde. 1.7.6 5-Chloro-1,2,3-Thiadiazole-4-Carbaldehyde. 1.7.7 Ethyl 5-amino-1,2,3-Thiadiazole-4-Carboxylate. 1.7.7.1 Pechmann Method. 1.7.7.2 Wolff Method. 1.7.8 Ethyl 5-chloro-1,2,3-Thiadiazole-4-Carboxylate. 1.7.9 4-Phenyl-2-(2,4,6-Trichlorophenyl)-1,2,3-Thiadiazolium Chloride. 1.7.10 5-Amino-4-ethoxycarbonyl-2-phenyl-1,2,3-thiadiazolium bromide. References. 2 Structure of 1,2,3-Thiadiazoles. 2.1 Theoretical Methods. 2.2 Experimental Structural Methods. 2.2.1 X-ray Analysis. 2.2.2 Nuclear Magnetic Resonance Spectroscopy. 2.2.2.1 Proton NMR Spectroscopy. 2.2.2.2 Carbon-13 NMR Spectroscopy. 2.2.2.3 Nitrogen-14 NMR Spectroscopy. 2.2.2.4 Nitrogen-15 NMR Spectroscopy. 2.2.3 Mass Spectrometry. 2.2.4 Other Spectroscopic Data. References. 3 Chemical Properties of 1,2,3-Thiadiazoles. 3.1 Reactions due to the Reactivity of Ring Atoms. 3.1.1 Reactions with Electrophiles. 3.1.1.1 Protonation. 3.1.1.2 Complexation. 3.1.1.3 Alkylation. 3.1.1.4 Acylation. 3.1.1.5 Oxidation. 3.1.1.6 Electrophilic Substitution of Hydrogen. 3.1.2 Reactions with Nucleophiles. 3.1.2.1 Attack at the Sulfur Atom. 3.1.2.2 Attack at the C5 Atom. 3.1.2.3 Attacks at H4 and H5. 3.1.2.4 Cycloaddition Reactions. 3.2 Reactions of Substituents. 3.2.1 5-Alkyl-1,2,3-thiadiazoles. 3.2.2 1,2,3-Thiadiazole-4-carbaldehyde. 3.2.3 5-Amino-1,2,3-thiadiazole-4-carbothioamide. 3.2.4 Mercapto-1,2,3-thiadiazoles. 3.3 Rearrangements. 3.3.1 Dimroth-type Rearrangements. 3.3.2 Cornforth-type Rearrangements. 3.3.2.1 Rearrangements of 4-(iminomethyl)-substituted-1,2,3-Thiadiazoles. 3.3.2.2 Degenerate Rearrangements of 4-Thiocarbamoyl-1,2,3-Thiadiazoles. 3.3.2.3 Rearrangements of 1,2,3-Thiadiazoles Bearing Diazo, Azido and Hydrazono Groups in the 5-Position. 3.3.2.4 Tandem Rearrangements. 3.4 Ring Cleavage of 1,2,3-Thiadiazoles. 3.4.1 Thermal Decomposition. 3.4.2 Photochemical Decomposition. 3.4.3 Base-catalyzed Decomposition. 3.4.4 Oxidative and Reductive Processes. 3.4.5 Other Processes for Ring Cleavage. References. 4 Fused 1,2,3-Thiadiazoles. 4.1 1,2,3-Thiadiazoles Fused with Five-Membered Rings. 4.1.1 Cyclopenteno-1,2,3-thiadiazoles. 4.1.2 Pyrrolo[2,3-d][1,2,3]thiadiazoles. 4.1.3 Pyrrolo[3,2-d][1,2,3]thiadiazoles. 4.1.4 Pyrrolo[3,4-d][1,2,3]thiadiazoles. 4.1.5 4,6-Dihydrofurano[3,4-d][1,2,3]thiadiazoles. 4.1.6 Thieno[2,3-d][1,2,3]thiadiazoles. 4.1.7 Thieno[3,2-d][1,2,3]thiadiazoles. 4.1.8 Thieno[3,4-d][1,2,3]thiadiazoles. 4.1.9 Selenopheno[3,4-d][1,2,3]thiadiazole. 4.1.10 Benzoselenopheno[3,2-d][1,2,3]thiadiazole. 4.2 1,2,3-Thiadiazoles Fused with Six-Membered Rings. 4.2.1 Cyclohexeno-1,2,3-thiadiazoles. 4.2.2 Benzo-1,2,3-thiadiazoles. 4.2.3 Piperidino[3,4-d][1,2,3]thiadiazoles. 4.2.4 1,2,3-Thiadiazolo[4,5-b]pyridines. 4.2.5 1,2,3-Thiadiazolo[4,5-c]pyridines. 4.2.6 1,2,3-Thiadiazolo[5,4-c]pyridines. 4.2.7 1,2,3-Thiadiazolo[5,4-d]pyrimidines. 4.2.8 1,2,3-Thiadiazolo[4,5-d]pyrimidines. 4.2.9 Pyrano[3,4-d][1,2,3]thiadiazole. 4.2.10 Thiopyrano[4,3-d][1,2,3]thiadiazoles. 4.2.11 Thiopyrano[2,1-d][1,2,3]thiadiazole. 4.2.12 Selenopyrano[4,3-d][1,2,3]thiadiazoles. 4.3 1,2,3-Thiadiazoles Fused with Seven-Membered Rings. 4.3.1 Benzooxepino- and Benzothiepino[3,4-d][1,2,3]thiadiazoles. 4.3.2 Thiadiazolo[5,4-d]benzazepines. 4.3.3 1,2,3-Thiadiazolo[5,4-b][1,5]benzodiazepine. 4.4 Bicyclic 1,2,3-Thiadiazoles of Azathiapentalenic Structure. References. 5 Synthesis and Properties of 1,2,3-Selenadiazoles. 5.1 Synthesis of 1,2,3-Selenadiazoles. 5.1.1 Oxidative Cyclization of Hydrazones by Se-containing Reagents. 5.1.2 Cycloaddition Reactions of Diazoalkanes with Compounds Containing C=Se Bonds. 5.1.3 Elaboration of Preformed 1,2,3-Selenadiazoles. 5.1.4 Miscellaneous Syntheses. 5.2 Structural Data of 1,2,3-Selenadiazoles. 5.2.1 Mass Spectrometry. 5.2.2 Proton NMR Spectroscopy. 5.2.3 Carbon-13 NMR Spectroscopy. 5.2.4 Nitrogen-15 NMR Spectroscopy. 5.2.5 Selenium-77 NMR Spectroscopy. 5.2.6 X-ray Crystallography. 5.2.7 Miscellaneous. 5.3 Reactivity of 1,2,3-Selenadiazoles. 5.3.1 Ring Cleavage. 5.3.1.1 Thermal Reactions. 5.3.1.2 Photochemical Reactions. 5.3.1.3 Base-catalyzed Reactions. 5.3.1.4 Radical-catalyzed Reactions. 5.3.1.5 Reaction with Metal Complexes. 5.3.1.6 Miscellaneous Ring Cleavage Reactions. 5.3.2 Formation of Salts and Ylides. 5.4 Fused 1,2,3-Selenadiazoles. 5.4.1 Bicyclic 1,2,3-Selenadiazoles. 5.4.2 Tricyclic 1,2,3-Selenadiazoles. 5.4.3 Tetra- and Pentacyclic 1,2,3-Selenadiazoles. 5.5 Applications of 1,2,3-Selenadiazoles. References. 6 1,2,3-Thiadiazoles in Medicine and Agriculture. 6.1 Medicine. 6.2 Agriculture. 6.2.1 Thidiazuron. 6.2.2 Bion. References. Index.

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詳細情報

• NII書誌ID(NCID): BA68136143
• ISBN:
  • 0471326623
• 出版国コード: us
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: Hoboken, N.J.
• ページ数/冊数: xv, 241 p.
• 大きさ: 24 cm
• 件名:
  • LCSH : Heterocyclic compounds
  • LCSH : Organic cyclic compounds
• 親書誌ID:
  • BA01564242