Osteoporosis in clinical practice : a practical guide for diagnosis and treatment
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書誌事項
Osteoporosis in clinical practice : a practical guide for diagnosis and treatment
Springer, c2004
2nd ed
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
When I was a young intern in internal medicine,osteoporosis was defined mainly as a fracture occurring in elderly people. However,although plain X-ray examination was recognized as an insensitive way to detect osteoporosis, hypodense bone was already considered as the reflection of the disease. Over the past 20 years, con siderable progress has been accomplished. In terms of prevalence, incidence, risk factors, and the burden of osteoporosis and low-energy fracture, we can appreciate the magnitude of the problem and its impact on quality oflife. Weare wellaware that vertebral fracture, which can be acutely associated with a low clinical expression, leads to significant long-term impairments. The costs for the individual and for the health budget, Le. society,are estimated better. Wenow have a clear definition of the disease, such as low bone mass and architectural defects, resulting in increased fragility. For the former part of the definition, the clinician can use accurate and pre cise tools allowing them to distinguish how their patient's bone mineral content differs from that of a young healthy population in which fracture occurs very rarely. For the second series of fragility determinants, i. e. structure, methods are in rapid progress and will provide information to clinicians on these variables in the near future. Basicand clinical research have allowed major improvements in the understand ing of the pathophysiology of the disease. Newgenes implicated in lowand/or high bone mass have been characterized.
目次
Introduction: General Outlines of Assessment and Management of Osteoporosis: Postmenopausal Osteoporosis as an Example Piet Geusens, Robert Lindsay and Philip Sambrook PART 1: General aspects of bone, osteoporosis and fractures 1. Normal Skeletal Structure & Function Philip Sambrook and Piet Geusens 2. Physiology of Calcium Homeostasis and Bone Remodeling Dirk Vanderschueren, Steven Boonen and Roger Bouillon 3. Biomechanics of Bone and Fracture Lis Mosekilde 4. Pathophysiology of Fractures Michael R. McClung 5. Epidemiology of Osteoporotic Fractures Elaine Dennison and Cyrus Cooper 6. Socio-Economic Impact L. Joseph Melton, III PART 2: Investigations in osteoporosis 7. Bone Densitometry, Radiography, and Quantitative Ultrasound for the Diagnostic Assessment of Osteoporosis Claus-C. Gluer 8. Biochemical Indices of Bone Turnover Markus J. Seibel 9. Dual-Energy X-Ray Based Absorptiometry (DXA) in Daily Clinical Practice Piet Geusens 10. Differential Diagnosis: Back Pain and Osteoporosis Kristina Akesson and Anthony D. Woolf 11. Differential Diagnosis: Bone Pain and Fractures Carlo Gennari and S. Gonnelli 12. Falls in Older People Stephen R. Lord, Hylton B. Menz and Catherine Sherrington 13. Genes and Osteopororis Stuart H. Ralston PART 3: Treatment of osteoporosis 14. Prevention Early After Menopause John C. Stevenson 15. Pharmacologic and Non-Pharmacologic Strategies to Prevent Hip Fracture in Old Age Steven Boonen, Patrick Haentjens and Dirk Vanderschueren SECTION 1: Drug treatment of osteoporosis 16a. Selective Estrogen Receptor Modulators Robert Lindsay 16b. Bisphosphonate Therapy for Osteoporosis Henry Bone 16c. Anabolic Drug Therapy in Osteoporosis Piet Geusens and Robert Lindsay 17. Surgical Therapy of Fractures Karl J. Obrant and Olof Johnell 18. Osteoporosis in Men Ego Seeman 19. Corticosteroid
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