内容説明
For over 25 years the study of retroviruses has underpinned much of what is known about information transfer in cells and the genetic and biochemical mechanisms that underlie cell growth and cancer induction. Emergent diseases such as AIDS and adult T-cell lymphoma have widened even further the community of investigators directly concerned with retroviruses, a development that has highlighted the need for an integrated understanding of their biology and their unique association with host genomes. This remarkable volume satisfies that need. Written by a group of the field's most distinguished investigators, rigorously edited to provide a seamless narrative, and elegantly designed for clarity and readability, this book is an instant classic that demands attention from scientists and physicians studying retroviruses and the disorders in which they play a role.
目次
Chapter 1 Historical Introduction to the General Properties of Retroviruses (P. K. Vogt) Chapter 2 Retrovirual Virions and Genomes (V. M. Vogt) Chapter 3 Viral Entry and Receptors (E. Hunter) Chapter 4 Reverse Transcriptase and the Generation of Retroviral DNA (A. Telesnitsky and S. P. Goff) Chapter 5 Integration (P. O. Brown) Chapter 6 Synthesis and Processing of Viral RNA (A.B. Rabson and B.J. Graves) Chapter 7 Synthesis, Assembly, and Processing of Viral Proteins (R. Swanstrom and J. W. Wills) Intermezzo The Interactions of Retroviruses and Their Hosts (J.M. Coffin, S.H. Hughes, and H.E. Varmus) Chapter 8 Retrotransposons, Endogenous Retroviruses, and the Evolution of Retroelements (J. D. Boeke and J. P. Stoye) Chapter 9 Development and Applications of Retroviral Vectors (A. D. Miller) Chapter 10 Retroviral Pathogenesis (N. Rosenberg and P. Jolicoeur) Chapter 11 Pathogenesis of HIV and SIV (A. S. Fauci and R. C. Desrosiers) Chapter 12 Immunological and Pharmacological Approaches to the Control of Retroviral Infections (E. A. Emini and H.Y. Fan) Appendix 1 Retroviral Sequences (G. Myers) Appendix 2 Retroviral Taxonomy, Protein Structures, Sequences, and Genetic Maps (C. Petropoulos)
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