Atherosclerosis XIII : proceedings of the 13th International Atherosclerosis Symposium held in Kyoto, Japan between 28 September and 2 October 2003

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書誌事項

Atherosclerosis XIII : proceedings of the 13th International Atherosclerosis Symposium held in Kyoto, Japan between 28 September and 2 October 2003

editors, Yuji Matsuzawa ... [et al.]

（International congress series, no. 1262）

Elsevier, 2004

タイトル別名

Atherosclerosis thirteen

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

This volume contains papers presented at the XIIIth International Symposium on Atherosclerosis (ISA). It summarizes the scientific and technological achievements in the field of Atherosclerosis in the 20th Century, and looks ahead to the potential for future progress and development in this new millennium. Research topics encompass all aspects of atherosclerosis, including: Epidemiology, Pathogenesis, Diagnosis, Prevention and treatment. Highlighting the recent advances in the research of vascular biology, angiogenesis and atherogenesis, the importance of multiple risk factor clustering and the mechanism of metabolic syndrome, this volume of the "International Congress Series" will satisfy and encourage the readers of the scientific community of atherosclerosis research.

目次

  • Preface. Young Investigator Award. International Atherosclerosis Society. XIIIth International Symposium on Atherosclerosis. International Advisory Board. Young Investigator Award Committee. Acknowledgements. Plenary lectures. The origin of the statins (A. Endo). New frontiers in atherosclerosis prevention and treatment: HDL as a novel therapeutic target (C.R. Sirtori). Therapeutic angiogenesis (S. Yla-Herttuala). Genetics, obesity, and the metabolic syndrome: The Professor Donald S. Fredrickson Memorial Lecture (S.M. Grundy). PPAR- #945
  • and atherosclerosis from basic research to clinical applications (J.-C. Fruchart, P. Duriez). Risk assessment of myocardial infarction and stroke (G. Assmann, P. Cullen, H. Schulte). Understanding atherothrombosis: from vulnerable plaque to vulnerable patient (P.R. Moreno, R. Corti, V. Fuster). Symposium. Nuclear receptors as a target for treatment. PPAR #947
  • fundamental role in adipogenesis (T.-A. Cock, J. Auwerx). Peroxisome proliferator-activated receptor gamma - insights from human genetics (V.K.K. Chatterjee). Fatty acids, cholesterol, and sphingolipids: interactive regulators and targets for SREBP processing (R.A. Juliano, R.J. Deckelbaum, T.S. Worgall). Immunity and inflammation in atherosclerosis. Detrimental and protective roles of adaptive immunity in atherosclerosis (G.K. Hansson, G.P. Berne, X. Zhou). The long pentraxin PTX3: from innate immunity to ischemic heart disorders (B. Bottazzi et al.). Plaque instability and acute coronary syndrome. Vascular biology of collagenases in vulnerable atherosclerotic plaques (M. Aikawa). Oxidative stress and inflammation in plaque instability - role of vascular C-reactive protein (N. Inoue, S. Kobayashi, M. Yokoyama). Plaque instability in human coronary atherosclerotic lesions: roles of oxidized LDL and neutrophils (M. Ueda et al.). Development of vascular systems
  • from capillary to the heart. Plasmin activates VEGF-C and VEGF-D (B.K. McColl et al.). Oxidized lipoprotein and atherosclerosis. Oxidized lipoprotein regulation of tissue factor in smooth muscle cells (S.-L. Liang et al.). Measurement of oxidized LDL present in human plasma and atherosclerotic lesions (H. Itabeet al.). Paraoxonase 1: biochemistry and contribution to atherosclerosis (B. Mackness, M. Mackness). Image analysis of atherosclerotic lesions and therapeutic application. High-resolution magnetic resonance imaging of carotid atherosclerosis (T.S. Hatsukami et al.). Angioscopic assessment of vulnerable plaque and therapeutic application-lessons from acute coronary syndrome (A. Hirayama, Y. Yeda, K. Kodama). Proliferation and differentiation of smooth muscle cells. Signal transduction regulating the vascular smooth muscle phenotype and early molecular events of atherogenesis (K. Sobue, K. Shibata, K. Hayashi). KLF5/BTEB2, a Kruppel-like zinc-finger type transcription factor, mediates smooth muscle cell activation as well as cardiovascular remodeling (R. Nagai et al.). Rho and smooth muscle cell phenotype (N.F. Worth et al.). Vascular tissue engineering and clinical applications. Induction of endothelialization of tissue-engineered cardiovascular constructs via in vivo angiogenesis during post-implant remodeling (H.P. Greisler). Body cavities as bioreactors to grow arteries (J.H. Campbell et al.). Critical issues in vascular tissue engineering (R.M. Nerem). Recent optimization of a tissue engineered blood vessel: the LOEX experience (F.A. Auger et al.). Molecular basis of endothelial activation. Atheroprotective mechanisms of flow: inhibition of apoptosis (X. Pi, C. Yan, B.C. Berk). A molecular mechanism for mechanical activation of endothelial cells (K. Fujiwara et al.). Role of TRP channels in endothelial pathophysiology-evidence for vascular TRPs as a potential target for drug therapy (A. Graziani et al.). Featured symposium. Diabetic angiopathy. PPAR- #947
  • signalling and vascular cells in 2003 (D. Bruemmer et al.). Exogenous and endogenous mechanisms of PPAR activation: implications for inflammation and atherosclerosis (O. Ziouzenkova, J. Plutzky). The role of protein kinase C activation in cardiovascular dysfunctions of diabetes and insulin resistance (Y. Yasuda, G.L. King). Cellular crosstalk under hyperglycemic stress-the diabetic retina as a paradigm (J. Lin et al.). Molecular mechanisms of retinal neovascularization in diabetic retinopathy (H. Takagi et al.). Nurture vs. nature in diabetic vasculopathy: roles of advanced glycation endproducts and the receptor for them (Y. Yamamoto et al.). Life style and vascular disease - the West and the East meet together. Geoethnic-sensitive and cross-culture differences of dietary patterns and blood pressure among five ethnic populations in China (L. Liu et al.). Homocysteine and folate: from genes to greens (L. Tokgozoglu). Diet, physical activity, childhood obesity and risk of cardiovascular disease (Y. Wang). The impact of westernization on the risk of atherosclerotic vascular disease among Japanese-American men in Hawaii (K. Yano et al.). How can we propose global guidelines for prevention of atherosclerosis? Global guidelines: national issues (P. Barter). Japan Atherosclerosis Society (JAS) guidelines for diagnosis and treatment of atherosclerotic cardiovascular diseases (H. Mabuchi). Low HDL-C: lessons learned from the Turkish Heart Study (U. Hodoglugil, D. Williamson, R.W. Mahley). Is hypertriglyceridemia an independent risk factor for coronary heart disease? A debate over the centuries.Nonfasting serum triglycerides and risk of ischemic heart disease among Japanese men and women (H. Iso et al.). Hypercholesterolemia and hypertriglyceridemia-greatest cardiac risk in subjects with high apoB/apoA-I levels (G. Walldius, A. Aastveit, I. Jungner). Are plasma triglycerides a good predictor of CHD risk? (P.J. Talmud et al.). Molecular basis of metabolic syndrome. The role of atypical PKCs in insulin-resistant states (R.V. Farese). PPAR #945
  • controlling HDL metabolism and atherosclerosis (R. Paumelle et al.). Genetic and genomic studies of type 2 diabetes in mice (A.D. Attie). Genetics of the metabolic syndrome and implications for therapy (R.I. Hughes, T.J. Aitman). HDL and reverse cholesterol transport. Unraveling the role of phospholipid transfer protein (PLTP) in lipoprotein metabolism and atherogenesis (S. Siggins et al.). Effect of hormone replacement therapy on the reverse cholesterol transport (C. Calvo). Bridging the decades: A new era with preclinical and clinical trials has started. Bridging the decades: new era is open for preclinical and clinical trials: Introductory remarks - "looking back the past decades" (A. Yamamoto). Ezetimibe: first in a new class of cholesterol absorption inhibitors (H.R. Davis). Biological therapies for dyslipidemia (M.H. Davidson). State of the art symposium. Atherosclerosis: A multifactorial disease. What happens inside an atherosclerotic plaque? (P. Libby). Seeing is believing: imaging techniques to measure atherosclerosis progression (S.E. Nissen). Past, present, and future clinical trials of cardiovascular risk reduction-the hypertension perspective (T. Fujita). Past, present, and future clinical trials of cardiovascular risk reduction - the hyperlipidemia perspective (N.R. Poulter). A targeted dual therapy approach to cardiovascular risk reduction (R.P. Mason). The metabolic syndrome: A new reality above and beyond conventional risk factors. Prevalence of low HDL-cholesterol and the metabolic syndrome (S. Yamashita et al.). Workshop. Molecular basis of blood vessel formation: From hypoxia to cell signaling. Positive and negative regulation of endothelial cell function (L. Claesson-Welsh). VEGF and its receptors (N. Ferrara). Oxygen regulates brain angiogenesis and tight junction formation in blood-brain barrier (S.-W. Lee et al.). Regulation of vascular remodeling and cardiovascular protection. Non-genomic activation of protein kinase Akt by steroid hormones (J.K. Liao). Regulation of vascular remodeling and cardiovascular protection: NFnB and vascular remodeling (B.R. Binder, J.M. Breuss). Molecular basis of lipoprotein disorders. Sitosterolemia
  • of mice and man (S.B. Patel et al.). Molecular defects in the ABCA1 pathway affect HDL metabolism and function of macrophages (G. Schmitz). Novel genetic markers for structural coronary artery disease, myocardial infarction, and familial combined hyperlipidemia: candidate and genome scans of functional SNPs (J.P. Kane et al.). Nutritional strategy for prevention of atherosclerosis. Nutrition and inflammation: role of dietary cholesterol (A. Chait et al.). Isoflavones: effects on cardiovascular risk and functions (P. Nestel). Flavonoids-rich nutrients with potent antioxidant activity prevent atherosclerosis development: the licorice example (M. Aviram). Recent lifestyle trials in the prevention of type 2 diabetes (J. Tuomilehto, J. Lindstrom). Therapeutic angiogenesis for vascular diseases. Therapeutic angiogenesis: cellular approach from bone marrow, cord blood and peripheral blood (T. Murohara). Cardiomyocyte regeneration following angioblast-dependent neovascularization of ischemic myocardium (M.D. Schuster et al.). Asian sessions: Cerebrovascular diseases and their treatment in Asian countries. Changes in incidence and mortality of stroke and risk factors in a Japanese general population: the Hisayama study (M. Fujishima, Y. Kiyohara). Stroke in Korea (J.S. Kim). Stroke therapies in Asian populations (G.A. Donnan, M. Koga, B.B. Pedreira). Interventional cardiology forum. Administration of control-released basic fibroblast growth factor - Is it a more effective angiogenic therapy than bone marrow cell transplantation for severely ischemic hearts? (K. Tambara et al.). Will all postinfarction patients receive defibrillators? Recent trials and expanding indications (P.A. Friedman). First human randomized trial of G-CSF stem cell mobilization to treat large acute myocardial infarction-preliminary results of a pilot study (S.G. Ellis et al.). Obesity, insulin resistance and atherosclerosis. Adiponectin as a potential key player in metabolic syndrome: Insights into atherosclerosis, diabetes and cancer (T. Funahashi, Y. Matsuzawa, S. Kihara). Obesity and other risk factors for cardiovascular diseases among Africans: results from CARDIAC study in Tanzania (M. Njelekela et al.). On behalf of the WHO cardiovascular diseases and alimentary comparison (CARDIAC) study group. Thrombosis in vascular disease. Homocysteine as a risk factor of cardiovascular disease (M. Merkel). Omega-3 fatty acids, thrombosis and vascular disease (W.S. Harris). Gene targeting and animal models of atherosclerosis. Genetic manipulation of macrophage - and vascular genes in mouse models of atherosclerosis (Th.J.C. van Berkel et al.). ApoE4 trapping by the low density lipoprotein receptor (M.K. Altenburg et al.). Intracellular lipid transport system and metabolism. Signal transduction pathways in free cholesterol-loaded macrophages: cell biological insight into the progression of atherosclerosis (I. Tabas). Caveolin and cholesterol in lipid transport and signaling (C.J. Fielding). MTP/apoB mediated lipoprotein assembly: an emerging pathway for lipid secretion and transport (J.R. Wetterau). Extracellular matrix and proteases in vascular medicine. The pro-inflammatory nature of the vascular extracellular matrix (T.N. Wight et al.). Regulation of extracellular matrix production and degradation of endothelial cells by shear stress (T. Yamane et al.). The elastin-laminin receptor-mediated matrix degradation. Effect of glucose concentration. Role in atherosclerosis (G. Faury et al.). The role of extracellular matrix in restenosis after percutaneous coronary intervention (I.-M. Chung). Novel anti-inflammatory properties of the Na+/H+ exchange inhibitor ethylisopropylamiloride result in attenuation of atherogenesis in apolipoprotein Edeficient mice (Y.-X. Chen, S. Whitman, E. O'Brien). Infection and atherosclerosis: Where do we currently stand? Infections and atherosclerosis - is serology useful? (P. Saikku). Infection and atherosclerosis: mechanisms involving Chlamydia pneumoniae in cardiovascular disease (G.I. Byrne, S.P. Ouellette, R.J. Belland). Interaction of host and microbes in the atherosclerotic plaques (J. Rupp, M. Maass). Detection of infective agents in atherosclerotic tissues (K. Ouchi). Asian sessions: Trends in cardiovascular diseases in Asian countries. Trends of cardiovascular diseases among Koreans (H.K. Lee). Prevalence of metabolic syndrome among adult Filipinos (F.E.R. Punzalan, R.G. Sy, T. Ty-Willing). Trends in cardiovascular diseases and risk factors in Malaysia (R. Zambahari). Fibrinolysis and proteolysis in vascular disease. The von Hippel-Lindau protein: a key player in oxygen homeostasis and matrix assembly (M.A. Esteban, S.J. Mandriota, P.H. Maxwell). Recent topics in research on hypertension and atherosclerosis. Mechanical stress-related atherosclerosis and functional genomics (H. Rakugi et al.). Hypolipidemic drugs, blood pressure, heart rate, heart rate variability and sympathetic activity (R. Ceska et al.). Renin-angiotensin system and vasculature-focusing on insulin's action (K. Kamide, M.L. Tuck). Risk factors of stroke: Recent evidence and new aspects. Stroke risk factors: recent evidence and new aspects (M. Cubrilo-Turek). Stroke-blood pressure and blood pressure-lowering (A. Tonkin). Carotid artery disease and risk of ischaemic stroke and coronary events (P.M. Rothwell). Remnant lipoprotein and lipoprotein (a) as risk factors for stroke and carotid disease (S. Uchiyama, M. Yamazaki, M. Iwata). Genetic risk factors for stroke: insights into pathophysiology from candidate gene approaches (S.E. Humphries, L. Morgan). Proteases in atherosclerotic plaque rupture. Matrix, matrix metalloproteinases and smooth muscle cell function in atherosclerosis (M.P. Bendeck et al.). Role of oxidant stress in vascular proteolysis (Z.S. Galis). The mast cell, a rich source of neutral proteases in atherosclerotic plaques (P.T. Kovanen et al.). Role of elastolytic cathepsins in vascular remodeling (G.K. Sukhova, G.-P. Shi, P. Libby). Health economics and policy. Economic burden of atherosclerosis-related diseases in Korea (C.-y. Kim). Diabetic dyslipidemia. CETP, a key player in atherogenic dyslipidemia of Type II diabetes (J.M. Chapman, M. Guerin). Triglycerides rich lipoproteins and atherosclerosis: in vitro and in vivo studies (G.D. Norata et al.). Dyslipidaemia, inflammation and endothelial dysfunction in diabetes mellitus (K. Tan). Postmenopausal woman and HRT: To be or not to be? What are certified scientific findings in HRT? Shall we proceed? (T. Hayashi). Hormone replacement therapy and atherosclerosis-postmenopausal women and HRT: the fallen myth of the cardiovascular protective effects of hormone replacement therapy (E.H. Moriguchi, J.L.C. Vieira). Hormone replacement therapy and cardiovascular disease (E. Windler, B. Eidenmuller, B.-Chr. Zyriax). Scavenger receptors. Function and regulation of hepatic scavenger receptor class B type I (SR-BI) (A. Rigotti). LOX-1, a lectin-like oxidized LDL receptor identified form endothelial cells, in endothelial dysfunction (T. Sawamura). Asian sessions: Metabolic syndrome in Asian countries. Metabolic syndrome and its relevance to Asia (E.D. Janus). Dietary habits, obesity status and cardiovascular risk factors in Koreans (J.H. Lee, Y. Jang, J.Y. Kim). Obesity as the key player in the metabolic syndrome (K.S.L. Lam et al.). The metabolic syndrome: an Asian perspective (C.-E. Tan, S.-K. Chew, E.-S. Tai). Lp(a) - Still a mystery. Lipoprotein (a) and atherosclerosis: a study from transgenic rabbits (J. Fan, T. Watanabe). The catabolism of lipoprotein(a) (G.M. Kostner et al.). The effect of methodological differences in the measurement of Lp(a) on the interpretation of clinical data (S.M. Marcovina). Aging and blood vessels. Molecular mechanisms of age-related regulation of genes (K. Kurachi et al.). Vascular cell senescence in human atherosclerosis (T. Minamino, I. Komuro). Role of inflammation in atherosclerotic calcification, metaplasia and osteoporosis (L.L. Demer, Y. Tintut, M. Abedin). ABC transporters and related disorders. Modulation of the ABCA1 transporter activity by protein kinase CK2 (S. Roosbeek et al.). Cloning, tissue distribution and function of ABCA transporters (N. Inagaki et al.). Geographic epidemiology of atherosclerotic diseases in different populations. Trends in morbidity, mortality, and risk factor levels of coronary heart disease in Japan - Are Japanese living in Japan still protected against coronary heart disease? (K. Kodama, F. Kasagi). Coronary heart disease in Japanese and Japanese Americans: does it provide clues for prevention? (J.D. Curb et al.). The pandemic of atherosclerosis in the Mediterranean area (O.A. Aziz). Meet the Professor session. What is the most important in treating hypertension? (K. Arakawa). Possible molecular mechanisms regulating endothelial repair in unstable fibroinflammatory atheroma (J.S.Y. Lee, B. Dickson, A.I. Gotlieb). Use of plasma markers as indices of sterol metabolism (G.R. Thompson). In Memoriam. Donald S. Fredrickson (August 8, 1924-June 7, 2002). Yuichiro Goto (October 6, 1922-May 28, 2003) (A.M. Gotto Jr.). Author index. Keyword index.

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