Cholinergic mechanisms : function and dysfunction

著者

書誌事項

Cholinergic mechanisms : function and dysfunction

edited by Israel silman, Hermona Soreq et al

Taylor & Francis, 2004

内容説明・目次

内容説明

Providing a cutting-edge profile of research progress in this important field of study, Cholinergic Mechanisms: Function and Dysfunction contains a compilation of the proceedings of the Eleventh ISCM, held in St. Moritz, May 2002. Bringing together 250 contributors from 30 countries, the book presents a comprehensive picture of the cholinergic field. It provides a survey of current understanding of molecular, pharmacological, toxicological, behavioral, and clinical aspects of the cholinergic system. This volume offers a state-of-the-art account of progress in the field from the molecule in the test tube through the cell and the synapse, to the organism and the patient.

目次

HEILBRONN LECTURE In Memoriam: Edith Heilbronn, V.P. Whittaker NICOTINIC RECEPTORS: STRUCTURE Nicotinic Acetylcholine Receptors: Probing Functionally Significant Structural Changes with Site-Directed Reactions, A. Karlin The Binding Site for -Bungarotoxin in the Acetylcholine Receptor: From Synthetic Peptides to Solution and Crystal Structure, S. Fuchs, R. Kasher, M. Balass, T. Scherf, M. Harel, M. Fridkin, J.L. Sussman, and E. Katchalski-Katzir Pharmacological and Structural Characterization of the Interaction of Snake Toxins with Nicotinic Acetylcholine Receptors, D. Servent, C. Fruchart-Gaillard, and A. Menez Structure and Dynamics of Acetylcholine Receptor and its Lipid Microenvironment: From Molecule to Cell, S. Antollini, J. Baier, M. Blanton, I. Bonini, B. De los Santos, M.C. Gallegos, I. Garbus, M.F. Pediconi, M. Prieto, A.M. Roccamo, J. Wenz, and F.J. Barrantes Site-Directed Reactive Probes for Structural and Functional Investigation of Cholinergic Proteins, C. Che, T. Grutter, A. Mourot, F. Hibert, and M. Goeldner The Mechanism for Acetylcholine Receptor Inhibition by -Neurotoxins and Species-Specific Resistance to -Bungarotoxin Revealed by NMR, A.O. Samson, T. Scherf, M. Eisenstein, J.H. Chill, and J. Anglister MUSCARINIC RECEPTORS: STRUCTURE Structure and Activation of Muscarinic Acetylcholine Receptors, E.C. Hulme, Z.L. Lu, J.W. Saldanha, and M.S. Bee Generation and Analysis of Muscarinic Acetylcholine Receptor Knockout Mice A. Duttaroy, M. Yamada, J. Gomeza, W. Zhang, T. Miyakawa, R. Makita, F.P. Bymaster, C.C. Felder, C.-X. Deng, and J. Wess Roles of External loops of Muscarinic Receptors in Interactions between N-Methylscopolamine and Allosteric Modulators, S. Tuc?ek, A. Krejc?i, M. Lysikova, J. Jakubik, and V. Dolez?al COUTEAUX LECTURE Rene Couteaux (1909-1999) and his Presynaptic Active Zone, S. Tsuji Rene Couteaux Lecture: Ligand Recognition in the Cholinergic Nervous System Analysed by Structural Templates and Protein Dynamics, P. Taylor PRESYNAPTIC MECHANISMS Neuronal Calcium Dynamics: One Message with Many Meanings, A. Fendyur, I. Kaiserman, and R. Rahamimoff Acetylcholine- and Glutamate-Mediated Transmission: One Mediatophore with Different Specificities, or Several Mediatophores? M. Israel and Y. Dunant The Ca-Voltage Hypothesis for Neurotransmitter Release - Current Status, H. Parnas and I. Parnas STRUCTURAL AND REGULATORY ASPECTS OF THE CHOLINERGIC SYNAPSE The Role of P2Y1 Nucleotide Receptors in the Formation and Maintenance of the Skeletal Neuromuscular Junctions, K.W.K. Tsim, R.C.Y. Choi, N.L. Siow, A.W.M. Cheng, K.K.Y. Ling, E.K.K. Tung, L.W. Kong, and E.A. Barnard Control of Expression of Nicotinic Receptor and Acetylcholinesterase in the Developing Neuromuscular Junction in the Human Muscle, Z. Grubic, K. Mis, M. Jevsek, M. Brank, M.P King, A.F. Miranda, J. Brecelj, and T. Mars The Molecular Neurobiology of Acetylcholinesterase Variants: From Stressful Insults to Antisense Intervention, H. Soreq, E. Meshorer, O. Cohen, R. Yirmiya, D. Ginzberg, and D. Glick Transcriptional Control of the Cholinergic Gene Locus: A Mosaic model for Regulation of the Cholinergic Phenotype, B. Schutz, M.K.-H. Schafer, E. Weihe, and L.E. Eiden Regulation of Cholinergic Gene Expression by NRSF/REST, L.B. Hersh and M. Shimojo Unveiling the Molecular Events Leading to a Neurotransmitter Phenotype Switch in Developing Neurons, Y. Bogoch, Y. Bledi, S. Tayar, and M. Linial MIRIAM SALPETER LECTURE Miriam M. Salpeter (Mika) - Biographical Notes, L. Anglister Chemical Kinetics Parameters and Receptor Degradation Rates at the Neuromuscular Junction, E.E. Salpeter STRUCTURAL AND FUNCTIONAL STUDIES ON CHOLINESTERASES Processing and Anchoring of Cholinesterases in Muscle and Brain, J. Massoulie and S. Bon X-Ray Structures of Native and Soman-Aged Human Butyrylcholinesterase: New Insights into the Catalytic Mechanism of Cholinesterases, F. Nachon, Y. Nicolet, P. Masson, O, Lockridge and J.-C. Fontecilla-Camps Intrinsic Tryptophan Fluorescence of Cholinesterases: Direct, Nonperturbing Monitoring of Enzyme-Ligand Interactions, Z. Radic', E. Kim, and P. Taylor Surprising Findings from the Functional Analysis of Human Acetylcholinesterase Adducts of Alzheimer's Disease Drugs, A. Ordentlich, D. Barak, N. Ariel, C. Kronman, D. Kaplan, B. Velan, and A. Shafferman Crystal Structure of the Tetramerization Domain of Acetylcholinesterase at 2.3 A Resolution, M. Harel, H. Dvir, S. Bon, W.Q. Liu, C. Garbay, J.L. Sussman, J. Massoulie, and I. Silman THE CHOLINERGIC SYSTEM IN INVERTEBRATES Structure and Expression of the Four Acetylcholinesterase Genes in the Nematode Caenorhabditis elegans, D. Combes, Y. Fedon, J.-P. Toutant, and M. Arpagaus Regulation of Cholinergic Neurotransmitter Phenotypes, P.M. Salvaterra, M.-H. Lee, and S. Song Molecular and Functional Diversity in the Nicotinic Acetylcholine Receptor Gene Families of Caenorhabditis elegans and Drosophila melanogaster, D.B. Sattelle, E. Culetto, and A.K. Jones Genetic Dissection of an Acetylcholine Receptor Involved in Neuronal Degeneration, M. Treinin, S. Halevi, and L. Yassin AUTOIMMUNE DISEASES RELATED TO THE CHOLINERGIC SYNAPSE Congenital Myasthenic Syndromes: Multiple Molecular Targets at the Neuromuscular Junction, A.G. Engel, K. Ohno, and S.M. Sine Antibodies to Acetylcholine Receptors and MuSK in Myasthenia Gravis and Related Disorders, A. Vincent, J. McConville, P. Plested, T. Tang, L. Jacobson, A. Polizzi, S. Riemersma, C. Newland, D. Beeson, J. Newsom-Davis, and W. Hoch Muscarinic Receptor Autoantibodies in Sjoegren's Syndrome, M. Rischmueller Immunotherapy of Myasthenia gravis: Antigen-Specific Mucosal Tolerance and Antagonists of Key Cytokines and Co-Stimulatory Factors, M.C. Souroujon, T. Feferman, P.K. Maiti, S.-H. Im, L. Raveh, and S. Fuchs TOXICOLOGY AND PHARMACOLOGY OF CHOLINESTERASE INHIBITORS A Complex Array of Post-Translation Modifications Determines the Circulatory Longevity of Acetylcholinesterase in a Hierarchical Manner, A. Shafferman, T. Chitlaru, A. Ordentlich, B. Velan, and C. Kronman Therapeutic Efficacy in Organophosphate Poisoning by Inhibiting Central Release of Acetylcholine, T.J.H. Bueters, B. Groen, P.K. Harrison, J.E.H. Tattersall, A.P. IJzerman, M. Danhof, and H.P.M. van Helden Polyurethane Immobilized Enzymes: Organophosphate-Sensing Matrixes, R.K. Gordon, A.T. Gunduz, B.P. Doctor, and T. Cronin Sex Differences in the Actions of Cholinesterase Inhibitors, M. Weinstock and R.-H. Wang Bifunctional Compounds Eliciting Both Anti-Inflammatory and Cholinergic Activity as Potential Drugs for CNS Disorders, G. Amitai, R. Adani, I. Rabinovitz, E. Beit-Yanai, E. Shohami, G. Sod-Moriah, and H. Meshulam BRZIN LECTURE In Memoriam: Miroslav Brzin (13 April 1923-8 August 1999), E. Reiner Acetylcholinesterase Regulation in Skeletal Muscles, N. C? rne-Finderle, P. Pregelj, and J. Sketelj PHARMACOLOGY OF NICOTINIC AND MUSCARINIC RECEPTORS IN THE CNS Nicotinic Receptor Modulation: Implications for Treatment of Alzheimer's Disease and Other Neurological Disorders, E.X. Albuquerque, E.F.R. Pereira, M. Samochocki, M. Alkondon, C. Ullmer, and A. Maelicke Common Structural and Pharmacological Properties of Serotonin 5-HT3 Receptors and 7 Nicotinic Acetylcholine Receptors, R. Zwart, M. Bodkin, L.M. Broad, G. De Filippi, P.J. Craig, T. Baldwinson, G. Benedetti, C. Felthouse, G.I. McPhie, K.H. Pearson, and E. Sher Autonomic Function of Neuronal Nicotinic Acetylcholine Receptor Subunits 5, 2 and 4: Study in Knockout Mice, N. Wang, A. Orr-Urtreger, and A.D. Korczyn Preclinical Studies of Galantamine Using a Form of Associative Learning Severely Impaired in Alzheimer's Disease, D.S. Woodruff-Pak New Evidence for the Involvement of Muscarinic Cholinergic Receptors in Psychoses, F.P. Bymaster, D.L. McKinzie, and C.C. Felder CHOLINERGIC-AMYLOID CROSS-TALK Beta-Amyloids, Tau Hyperphosphorylation, and Cognition are Beneficially Affected by M1 Muscarinic Agonists: Perspectives in Alzheimer's Disease Treatment, A. Fisher, Z. Pittel, R. Haring, N. Bons, N. Bar-Ner, H. Sonego, N. Natan, I. Marcovitch, and R. Brandeis PKC and MAP Kinase-Dependent Processing of Amyloid Precursor Protein (APP) by Neuroprotective Propargylamine Cholinesterase Inhibitors Derived from Rasagiline and Nonsteroidal Anti-Inflammatory Drugs, M.B.H. Youdim, T. Amit, Y. Avramovich, O. Bar-Am, M. Weinstock, and M. Yogev-Falach Neurodegenerative Processes in Alzheimer's Disease: Role of A -AChE Complexes and Wnt Signaling, N.C. Inestrosa, G. De Ferrari, C. Opazo, and A. Alvarez The Effects of ApoE3 and apoE4 on Lipid Synthesis and Uptake, L. Berger, A. Devir, M. Efrati, and D.M. Michaelson CHOLINERGIC PATHWAYS AND REGULATION IN THE CNS Cholinergic Cortical Terminations Establish Classical Synapses and Undergo Age-Related Atrophy, A.C. Cuello Development of Cholinergic Projections to Cortex: Possible Role of Neurotrophins in Target Selection, R.T. Robertson and J. Yu Activation of the Cholinergic System During Cognitive Processes, M.G. Giovannini, M.B. Passani, and G. Pepeu How is the Brain Protected against Excess Choline Concentrations? K. Loeffelholz and J. Klein Conditions for a Precursor Control of Acetylcholine Release in Mouse Hippocampus, J. Klein, M.-L. Buchholzer, S. Kopf, and K. Loeffelholz Cholinergic Neurons in Culture: Regulation of Structure and Functions, M. Segal and V. Greenberger CLINICAL STUDIES ON ALZHEIMER PATIENTS Cholinesterase Inhibitors Stabilize Cognitive Decline in Alzheimer Patients Through -Amyloid Metabolism Interaction, E. Giacobini Measuring Cerebral Acetylcholine Esterase Activity in Alzheimer Dementia by PET Functional Parametric Imaging, K. Herholz, G. Zundorf, B. Bauer, S. Weisenbach, and W.-D. Heiss Persistent Blood-Brain Barrier Disruption in Humans: A Window for Neurodegenerative Diseases, E. Avivi, O. Tomkins, A. Korn, L. Pavlovsky, I. Shelef, and A. Friedman The Cholinergic System and Cognitive and Noncognitive behavioral Dysfunction in Alzheimer's Disease, P.T. Francis and S.L. Minger CLOSING SESSION Conclusions and Comments: XI ISCM, A.G. Karczmar POSTER PRESENTATIONS A Single Amino Acid Substitution Found in Pirimicarb-Insensitive Acetylcholinesterase of the Peach-Potato Aphid, Myzus persicae (Sulz.), M.C. Andrews, C.G. Bass, M.S. Williamson, L.M. Field, A. Callaghan, and G.D. Moores The Effect of Diet Restriction, Separation Stress, Activity Wheel, and Tyrosine Administration on Cognitive Function and the Cholinergic System in Mice, Y. Avraham, S. Hao, and E.M. Berry Nicotine Induces Glutamate Release from Hippocampal Mossy Fiber Synaptosomes, V. Bancila, A. Bloc, and Y. Dunant Human Panic Disorder and the Cholinergic System: Further Considerations on a Gene-Environment Interaction Model, M. Battaglia, A. Ogliari, F. Villa, L. Ferini-Strambi, and C. Maffei A Zebrafish Mutant as a Model for an Acetylcholinesterase-Deficient Vertebrate, M. Behra, X. Cousin, C. Bertrand, J.-L. Vonesch, A. Chatonnet, and U. Strahle The Agonist Biphasic Dose-Response Curve of Human 4 2 Nicotinic Acetylcholine Receptors is Influenced by Ca2+ ions and Phosphokinase C, I. Bermudez and L.M. Houlihan Dramatic Depletion of Cell Surface Muscarinic Receptor Due to Limited Delivery from Intracytoplasmic Stores in Neurons of Acetylcholinesterase-Deficient Mice, V. Bernard, C. Brana, I. Liste, O. Lockridge, and B. Bloch Role of Spontaneous Mutations of Neuronal Nicotinic Acetylcholine Receptors in ADNFLE, D. Bertrand, I. Favre, H. Phillips, S. Bertrand, S.F. Berkovic, and J. Mulley Quantal Acetylcholine Release through Mediatophore Proteolipid, A. Bloc, J. Falk-Vairant, M. Malo, M. Israel, and Y. Dunant Superior Cervical Ganglia of the Cat: Cholinergic Mechanisms and their Relevance to Normal Mediation of Coordinate Respiratory and Deglutition Cervical Organs, B. Blum and J. Israeli Cholinergic Modulation of Chemotaxis in Human Melanoma Cells, A. Boss, M. Oppitz, G. Lippert, and U. Drews Some Considerations Concerning the Molecular Mechanism of Cholinesterase Catalysis, N.B. Brovtsyna, E.V. Rozengart, A.A. Suvorov, and S.N. Moralev Muscarinic Neuromodulation in the Hippocampus and Parahippocampal Region, R.O. Browne, L. Pavlovsky, and A. Friedman In Vivo Cholinergic Effects in the Rat of Head-to-Tail 3-Alkylpiridinium Polymers Isolated from the Marine Sponge Reniera sarai, M. Bunc, J. Rozman, M. Brvar, A. Vidmar, J.S. S?uput, and D. S?uput Candoxin: A New Snake Toxin Specific for the 7 Nicotinic Acetylcholine Receptor, E. Charpantier, S. Nirthanan, P. Gopalakrishnakone, M.C.E. Gwee, H.E. Khoo, L.S. Cheah, R. Manjunatha Kini, and D. Bertrand Effect of Post-Translation Modifications of Human Acetylcholinesterase on its Circulatory Residence, T. Chitlaru, C. Kronman, S. Lazar, N. Seliger, B. Velan, and A. Shafferman NF B Regulates the Promoter Activity of Human Acetylcholinesterase in Muscle, R.C.Y. Choi, N.L. Siow, A.W.M. Cheng, L.W. Kong, X. Zhang, D.C.C. Wan, and K.W.K. Tsim Generation of Pharmacokinetically Improved Recombinant Human Acetylcholinesterase by Polyethylene Glycol Modification, O. Cohen, C. Kronman, T. Chitlaru, A. Ordentlich, B. Velan, and A. Shafferman Interaction of Recombinant Soluble Neuroligin-1 with Neurexin-1-ss, D. Comoletti, R. Flynn, L. Jennings, R. Hoffman, P. Marchot, Y. Bourne, T. Sudhof, and P. Taylor A Calcium-Proton Antiport in Presynaptic Nerve Terminals, M. Cordeiro, V. Bancila, A. Bloc, P. Goncalves, and Y. Dunant Buprofezin and Novaluron Inhibit Acetylcholinesterase Activity in B-biotype Bemisia Tabaci, E.L.A. Cottage and R.V. Gunning A Peptide from the C-Terminal Oligomerization Domain of Human Synaptic (T-form) Acetylcholinesterase Forms Classical Amyloid Fibrils, M.G. Cottingham, M.S. Hollinshead, and D.J.T. Vaux Identification of Species Differences in the Pharmacology of the -7 Nicotinic Receptor Using the Antagonist Radioligand [3H]-Methyllycaconitine, N. Crawford, K. Finlayson, J. Sharkey, and J.S. Kelly Combination Donepezil and Dihydroepiandrosterone Therapy for Post-Stroke Rehabilitation, J.W. Crayton, L.M. Konopka, and A. Karczmar E. coli-expressed Extracellular Domain of Rat 7 Nicotinic Acetylcholine Receptor: Physicochemical and Binding Properties, N.I. Dergousova, E.A. Azeeva, E.V. Kryukova, E.D. Shibanova, I.E. Kasheverov, A.S. Korotina, Y.N. Utkin, and V.I. Tsetlin NO-Dependent and NO-Independent cGMP Synthesis in Cortical Cholinergic Neurons of the Rat Brain, J. de Vente, W.C.G. van Staveren, M. Markerink-van Ittersum, and H.W.M. Steinbusch Calcium Mobilization and Cellular Contraction of Embryonic Lens Vesicle and Neural Tube on Muscarinic Cholinergic Stimulation, U. Drews, M. Oppitz, and G. Schriek Phenotype of the Adult Acetylcholinesterase-Deficient Mouse: Evidence for a Role of Acetylcholinesterase in Development, E.G. Duysen, J.A. Stribley, D.L. Fry, S.H. Hinrichs, and O. Lockridge MALDI-TOF/MS Analysis of Tabun-Acetylcholinesterase Conjugate: A Tool for Resolution of the 'Aging' Pathway, E. Elhanany, A. Ordentlich, O. Dgany, D. Kaplan, Y. Segall, R. Barak, B.h Velan, and A. Shafferman Transgenic Manipulations of Neuromuscular Junction Maintenance, T. Evron and H. Soreq Tetanic Fade is Revealed by Blocking Presynaptic Nicotinic Receptors Containing 3 2 Subunits after Reducing the Safety Factor of Neuromuscular Transmission, M. Faria, L. Oliveira, M.A. Timoteo, M.G.B. Lobo, and P. Correia-de-Sa Functional Expression and Stoichiometry of the Novel Human 9 10 Heteromeric Nicotinic Acetylcholine Receptor, C. Grantham, I. Vandenberk, D. Nieuwstraten, P. Groot-Kormelink, L. Van der Helm, J. Yon, A. Kremer, P. Van der Spek, S. Masure, W. Luyten, and J. Andrews Piperonyl Butoxide: A Specific Inhibitor of Insecticide-Resistant Acetylcholinesterase, R.V. Gunning The Interaction of 2-Aminoperimidine with Cholinesterases, D. Gur, D. Segal, and Y. Shalitin Influence of Water on the Function of Acetylcholinesterase, R. Henchman, K. Tai, T. Shen, and J.A. McCammon -Conotoxins PnIA and [A10L]PnIA Stabilize Different States of the Chick Neuronal 7 Acetylcholine Receptor, R.C. Hogg, S. Bertrand, P.F. Alewood, D.J. Adams, and D.C. Bertrand Acetylcholinesterase Knockout Mice have Increased Sensitivity to Scopolamine and Atropine, A. Hrabovska, E. Duysen and O. Lockridge Investigating the Diversity of Acetylcholinesterase in Insect Species, N. Javed, M. Williamson, R. Viner, T. Lewis, and G. Moores Origin of Acetylcholinesterase in the in vitro Formed Neuromuscular Junction, M. Jevsek, T. Mars, K. Mis, and Z. Grubic Nicotinic 4 Receptor-Mediated Acetylcholine Release from Rat Interpenduncular Nucleus, F.A. Jones, L.R. Johnson, and I.A. Pullar Attempts to Engineer an Enzyme Mimic of Butyrylcholinesterase by Substitution of the Six Divergent Aromatic amino Acids in the Active Center of Acetylcholinesterase, D. Kaplan, A. Ordentlich, D. Barak, N. Ariel, C. Kronman, B. Velan, and A. Shafferman Mapping the Acetylcholine-Binding Sites of Torpedo Nicotinic Receptor Using Photoaffinity Labeling: Past, Present, and Future, F. Kotzyba-Hibert, A. Mourot, T. Grutter, and M. Goeldner Phosphonylation of Acetylcholinesterase and the Propensity for Reactivation Analysed by Chirality and Mutagenesis, Z. Kovarik, Z. Radic', H.A. Berman, and P. Taylor Some Basic Rules Governing Oligosaccharide-Dependent Circulatory Residence of Glycoproteins are Revealed by MALDI-TOF Mapping of the Multiple N N-Glycans Associated with Recombinant Bovine Acetylcholinesterase, C. Kronman, T. Chitlaru, N. Seliger, S. Lazar, A. Lazar, L. Zilberstein, B. Velan, and A. Shafferman Identification and Characterization of a Diverse Family of Neurotoxin-Like Peptides from the South American Coral Snake, T. Kubo, G. Baptista, X. Yang, S. Kobayashi, M. Takeda, A. Prieto-Da-Silva, and T. Yamane Muscarinic Acetylcholine Receptors are Down-Regulated in Acetylcholinesterase Knockout Mice, B. Li, E.G. Duysen, and O. Lockridge Altered Activity of Cholinergic Enzymes in Muscles and Brain of the Obese-Diabetic (ob/ob) Mouse, M.C. Lintern, L. Cooke, H. Scriven, C.J. Bailey, and M.E. Smith Two Possible Orientations of the HI-6 Molecule in the Reactivation of Organophosphate-Inhibited Acetylcholinesterase, C. Luo, H. Leader, Z. Radic', D.M. Maxwell, P. Taylor, B.P. Doctor, and A. Saxena Exploring the Acetylcholinesterase Gorge with Bis-Galanthamine Derivatives, E. Luttmann, E. Linnemann, and G. Fels Formation of Neuromuscular Junctions in Co-Cultures of Human Muscle and Rat Embryonic Spinal Cord is Accompanied by Differentiation of Neuronal and Glial Cells, T. Mars, K.J. Yu, X.-M. Tang, A.F. Miranda, F. Cambi, Z. Grubic, and M.P. King Hysteresis in Butyrylcholinesterase Catalysis: Evidence for Substrate-Induced Conversion of the Enzyme from Latent to Operative Form, P. Masson, M.-T. Froment, F. Nachon, and L.M. Schopfer mRNAs Encoding Acetylcholinesterase, Butyrylcholinesterase, and Agrin 19 Share the Same Temporal Pattern of Expression During Development of Rat Spinal Cord, K. Mis, E. Davidson, H. Park, M.P. King, T. Mars, M. Jevsek, M. Brank, and Z. Grubic New Essential Residues in the Cholinesterase Acyl Pocket, S.N. Moralev Brain Penetration and Behavioral Properties of a Potent 7 Nicotinic Acetylcholine Receptor Agonist in the Rat, N.A. Moore, D.L. McKinzie, S.N. Mitchell, M. Keenan, D.R. Dobson, G. Wishart, M.F. O'Neill, TK Murray, B Tree, S Iyengar, J Hart, D Shaw, RMA Simmons, AB Kalra, C Miles, M Conway, J.R. Boot, S.R. Baker, E. Sher, M.D. Tricklebank, and M.J. O'Neill Dopamine Release from Rat Striatal Slices in vitro and Functional Effects in 6-OHDA-Treated Rats in vivo are Mediated by 2 Nicotinic Acetylcholine Receptors, T.K. Murray, F.A. Jones, E. Tafi, D. Steggles, D.R. Dobson, C.P. Dell, I.A. Pullar and M.J. O'Neill Hydrocortisone Affects the Densities of Cardiac Muscarinic and Adrenergic Receptors, J. Myslivec?ek, J. R ? ic?ny', and S. Tuc?ek Fine-Tuning Modulation of Neuronal Muscarinic M1 (Facilitatory) and M2 (Inhibitory) Receptor Activation by Adenosine at the Rat Neuromuscular Junction, L. Oliveira, M.A. Timoteo, and P. Correia-de-Sa 7 Acetylcholine Receptor mRNA in Blood Lymphocytes: A Possible Peripheral Marker for Schizophrenia, O. Perl, T. Ilani, R.D. Strous, R. Lapidus, and S. Fuchs Effects of Methomyl on Cell Cycle and Apoptosis in Leukocytic Cells, T. Posayanonda, T. Suramana, N. Nuntharatanapong, W. Schwaeble, R. Snowden, N. Dusitsin, R. Sindhuphak, and P. Sinhaseni Segregation of Phosphatidic Acid-Rich Domains in Reconstituted Acetylcholine Receptor Membranes, J.A. Poveda, J.A. Encinar, A.M. Fernandez, C.R. Mateo, and J.M. Gonzalez-Ros Muscle Acetylcholinesterase Expression in Hyperthyreotic and Hypothyreotic rats, P. Pregelj and J. Sketelj Peripheral Binding of Ethopropazine to Horse Serum Butyrylcholinesterase, E. Reiner, G. S ? inko, A. S ? tuglin and V. Simeon-Rudolf Capillary Zone Electrophoresis Detects Unwanted Cholinesterase-Bound Hidden Ligands that Alter Enzyme Conformational Stability, D. Rochu, F. Renault, C. Bon, and P. Masson Plant Cholinesterase Activity as a Biosensor: Cellular Models, V.V. Roschchina Studies on the Mechanism of Blockade of Acetylcholine Release by Snake Presynaptic PLA2 Neurotoxins, O. Rossetto, M. Rigoni, P. Caccin, and C. Montecucco Variability of Substrate Specificity in Cholinesterases of Vertebrates and Invertebrates, E.V. Rozengart and S.N. Moralev Overexpression of the Extracellular and Cytoplasmic Domains of the Drosophila Adhesion Protein, gliotactin, E.H. Rydberg, R. Macion, T. Zeev-Ben-Mordehai, A. Solomon, D.M. Rees, L. Toker, S. Botti, V.J. Auld, I. Silman, and J.L. Sussman Targeting of the Vesicular Acetylcholine Transporter to Cholinergic Subdivisions in Transgenic Mice, B. Schutz, E. Weihe, and L.E. Eiden Ligand-Induced Conformational Changes in the Omega Loop of Acetylcholinesterase Revealed by Fluorescence Spectroscopy, J. Shi, Z. Radic', A.E. Boyd, D.A. Johnson, and P. Taylor 'Readthrough' Acetylcholinesterase and Cholinergic Neurotransmission, S. Shoham, E. Kovalev, E. Sklan, and H Soreq Comparison of Two Reaction Schemes for the Hydrolysis of Acetylthiocholine by Butyrylcholinesterase, V. Simeon-Rudolf, G. S ? inko, A. S ? tuglin, J. Stojan, M. Golic?nik, and E. Reiner Kinetics of Interaction of Ethopropazine Enantiomers with Butyrylcholinesterase and Acetylcholinesterase, G. S ? inko, Z. Radic', P. Taylor, V. Simeon-Rudolf, and E. Reiner Two-Hybrid Approach to the Intracellular Function(s) of Readthrough Acetylcholinesterase, E.H. Sklan, K. Birikh, and H. Soreq Effect of Pyridostigmine Administration on Acetylcholinesterase and Choline Acetyltransferase Activity in Guinea Pig Striatum and Cerebellum, M.E. Smith, M.C. Lintern, C.J. Brewer, and J.R. Wetherell Effects of Carbamate Insecticides on Rat Neuronal 4 4 Nicotinic Receptors and Rat Brain Acetylcholinesterase, C.J.G.M. Smulders, T.J.H. Bueters, R.G.D.M. van Kleef, and H.P.M. Vijverberg Calcium Conductance and Choline Sensitivity of Slow Channel Syndrome Acetylcholine Receptor Mutants, I. Spreadbury, R. Webster, D. Beeson, and A. Vincent Significance of Parameters in Various Kinetic Schemes for Cholinesterases, J. Stojan and M. Golic?nik Mechanism of Acetylcholinesterase Inhibition by Fasciculin: a 5-ns Molecular Dynamics Simulation, K. Tai, T. Shen, R.H. Henchman, Y. Bourne, P. Marchot, and J.A. McCammon Interaction between Stress and Pyridostigmine Pretreatment in the Mouse, L. Taysse, I. Delamanche, N. Perrier, and P. Breton Probing the Binding Interface between the Nicotinic Acetylcholine Receptor and a Short -Neurotoxin through Receptor-Biotinyltoxin-Streptavidin Ternary Complexes, F. Teixeira, A. Menez, and P. Kessler Huperzine A, A Promising Anti-Alzheimer's Agent, Reduces Staurosporine-Induced Apoptosis in NG108-15 Cells, X.-Q. Xiao, D.-C. Wu, Y. Gao, Y. Fu, N.T.K. Lee, W.-L. Ho, K.W.K. Tsim, and Y.-F. Han Effects of Lithium Chloride on Memory Performances of Mice in an Elevated Plus-Maze Test, P. Yamanturk and L. Erog?lu Effects of 7-Nitroindazole on Memory Performances of Rats Trained for a Three-Panel Runway Task: Hippocampal Cholinergic Enzyme Activities, P. Yamanturk, Y. UEnlucerci, S. Bekpinar, and H. Koyuncuog?lu Nicotinic Cholinergic Activation of Magnocellular Endocrine Neurons of the Hypothalamus, M. Zaninetti, E. Tribollet, D. Bertrand, R. Ogier, and M. Raggenbass Use of the Morphing Graphics Technique to Visualize Conformational Differences between Acetylcholinesterases from Different Species and Inhibitor-Induced Conformational Changes, T. Zeev-Ben-Mordehai, I. Silman, and J.L. Sussman Neuroprotective Effects of Huperzine A and Donepezil on Staurosporine-Induced Injury in Primary Cortical Neurons, H.Y. Zhang and X.C. Tang Cloning and Characterization of the Acetylcholinesterase Gene in the Chicken, X. Zhang, R. Choi, K.W.K. Tsim, and D.C.C. Wan

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詳細情報

• NII書誌ID(NCID): BA68808161
• ISBN:
  • 1841840750
• 出版国コード: uk
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: London
• ページ数/冊数: lxiv,774
• 大きさ: 26cm
• 分類:
  • DC21 : 612.822
• 件名:
  • LCSH : Cholinergic mechanisms