Chirality in drug design and development
著者
書誌事項
Chirality in drug design and development
M. Dekker, c2004
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Covering every essential element in the development of chiral products, this reference provides a solid overview of the formulation, biopharmaceutical characteristics, and regulatory issues impacting the production of these pharmaceuticals. It supports researchers as they evaluate the pharmacodynamic, pharmacokinetic, and toxicological characteristics of specific enantiomers and chiral drug compounds and addresses in one convenient reference all the major challenges pertaining to drug chirality that have been neglected in the literature. Chirality in Drug Design and Development collects the latest studies from an interdisciplinary team of experts on chiral drug design.
目次
Foreword, Fakhreddin Jamali, Preface, Contributors, 1. Effects of Crystal Structure and Physical Properties on the Release of Chiral Drugs, 2. Use of Chiral Excipients in Formulations Containing Chiral Drugs, 3. Transport of Chiral Molecules Across the Skin, 4. Stereoselective Drug Delivery Through Prodrug Approach, 5. Stereoselectivity in Drug Action and Disposition: An Overview, 6. Stereospecific Pharmacokinetics and Pharmacodynamics: Selected Classes of Drugs, 7. Stereospecific Pharmacokinetics and Pharmacodynamics: Cardiovascular Drugs, 8. Chiral Inversion, 9. Bioequivalency Determination of Racemic Drug Formulations: Is Stereospecific Assay Essential?, 10. Regulatory Considerations in Drug Development of Stereoisomers, Index
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