Biology of IGF-1 : its interaction with insulin in health and malignant states
著者
書誌事項
Biology of IGF-1 : its interaction with insulin in health and malignant states
（Novartis Foundation symposium, 262）
John Wiley & Sons, 2004
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
An invaluable book containing a series of interdisciplinary discussions between clinical and basic scientists. Biology of IGF-1: Its interaction with insulin and health and malignant states focuses on key issues such as:* the definition of danger zones* the development of methods for early recognition of malignant states linked to IGF-1 and/or insulin* possible approaches to preventative intervention* the relevance in this field of research to the development of novel therapeutic approaches to treating certain cancers.
目次
Chair's Introduction (Leroith). Circulating IGF-I and its role in cancer: lessons from the IGF-1 gene-deletion (LID) mouse (Yakar et al). Physiology of the IGF system (Holly). Molecular basis of insulin action (Zick). IGF-1 and insulin as growth hormones (Laron). Insulin-like growth factors and neoplasia (Pollak). Loss of IGF2 imprinting: mechanisms and consequences (Ohlsson). Insulin and IGF-1 receptor trafficking and sginalling (Foti et al). The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb (Nobukini and Thomas). Structural biology of insulin and IGF-1 receptors (De Meyts et al). Genetic blockade of the insulin-like growth factor-I receptor for human malignancy (Adachi et al). IGF-1 and prostate cancer (Roberts Jr.). IGF-1 and breast cancer (Lonning and Helle). IGFBPs and cancer (Fang et al). The IGF receptor as anti-cancer treatment target (Macaulay). Nutrition, insulin, IGF-1 metabolism and cancer risk: a summary of epidemiological evidence (Kaaks). Final discussion. Index of contributors. Subject index.
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