Gene genealogies, variation and evolution : a primer in coalescent theory
著者
書誌事項
Gene genealogies, variation and evolution : a primer in coalescent theory
Oxford University Press, 2005
- : hbk
- : pbk
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注記
Includes bibliographical references (p. [259]-271) and index
内容説明・目次
- 巻冊次
-
: hbk ISBN 9780198529958
内容説明
Coalescent theory is a central concept in the study of genetic sequence variation that probabilistically describes the genealogy relating the sampled sequences. In this text, besides fulfilling the glaring need for such a book, the authors present this theory in a straightforward and elementary manner and describe the statistical and computational methods used in modelling and analyzing genetic sequence variation. Rich in examples and illustrations the book covers basic concepts, complications arising from geographical structure and recombination before considering aspects of statistical inference based on these models. The book ends with chapters on Gene Mapping, which combines sequence variation data with phenotypic data (such as disease) to define areas of the genome where genes are responsible for the trait, and Human Evolution, a research area that is experiencing a renaissance due to the enormous amounts of data produced in molecular studies. Authored by leading experts, this seminal text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population.
It is highly suitable for a graduate course in statistics, population, molecular and medical genetics, bioscience and medicine and students studying the evolution of human population and disease, and will be an invaluable reference for bioscientists and statisticians in the pharmaceutical industry and academia.
目次
- Preface
- The basic coalescent
- From genealogies to sequences
- Trees and topologies
- Extensions to the basic coalescent
- The coalescent with recombination
- Getting parameters from data
- LD Mapping and the coalescent
- Human evolution
- Appendix: Web based tools
- 巻冊次
-
: pbk ISBN 9780198529965
内容説明
Authored by leading experts, this seminal text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. Rich in examples and illustrations it is ideal for a graduate course in statistics, population, molecular and medical genetics, bioscience and medicine, and for students studying the evolution of human population and disease. It is also an invaluable
reference for bioscientists and statisticians in the pharmaceutical industry and academia
目次
- Preface
- The basic coalescent
- From genealogies to sequences
- Trees and topologies
- Extensions to the basic coalescent
- The coalescent with recombination
- Getting parameters from data
- LD Mapping and the coalescent
- Human evolution
- Appendix: Web based tools
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