Genes, development, and cancer : the life and work of Edward B. Lewis
著者
書誌事項
Genes, development, and cancer : the life and work of Edward B. Lewis
Kluwer Academic Publishers, c2004
大学図書館所蔵 全2件
注記
Includes bibliographical references and index
内容説明・目次
内容説明
- For the first time, Nobel Prize winner, Edward B. Lewis' research papers are published within one volume
- Papers are organized into sections that reflect the focus of the research
- Commentaries by Howard Lipshitz highlight key methods and results by explaining the science so it is accessible to upper-level undergraduates, graduate students, and professional researchers
目次
Background -Invention of the cis-trans test for position effects -Position pseudoalleles -The bithorax pseudoalleles and the concept of developmental control -Gene evolution by tandem duplication -From cisvection to transvection- Extending the bithorax pseudoallelic series -Genetic versus functional models -From genes to gene complexes -Developmental genetics -Gain-of-function and loss-of-function alleles, and the operon model -Genetic mosaics: spatial and temporal aspects of bithorax function -The 1978 paper: a paradigm for the genetic control of development -Trans-acting regulators: positive and negative control of the homeotic complexes -Cis-regulation within the BX-C: the rules of engagement -Positional cloning of the BX-C -Completing the bithorax mutant series -The molecular basis of developmental control -Bithorax and the evolution of sexually dimorphic traits -DNA sequence motifs in the cis-regulatory regions of the BX-C -Evolution of the HOX complexes -Genetic and somatic effects of ionizing radiation -The political and social context -Leukemia and ionizing radiation -Political fallout -Thyroid radiation doses from weapons fallout -Best estimates of risk: leukemia in populations exposed to low doses of radiation -Estimates of lung cancer risk: the Batelle beagles
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