Chronic lymphocytic leukemia : molecular genetics, biology, diagnosis, and management
著者
書誌事項
Chronic lymphocytic leukemia : molecular genetics, biology, diagnosis, and management
(Contemporary hematology)
Humana Press, c2004
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注記
Includes bibliographical references and index
HTTP:URL=http://www.loc.gov/catdir/toc/fy043/2003041670.html Information=Table of contents
内容説明・目次
内容説明
A comprehensive and critical review of the latest scientific advances in our understanding of the molecular genetics and biology of CLL and their application to the best management of CLL. The authors focus on diagnosis, prognosis, multifaceted treatment options, and complications. Among the diverse treatments considered are chemotherapy, autologous and allogenic transplantations, monoclonal antibody therapy, immunotoxin therapy, gene therapy, and several new therapeutic strategies. Familial and juvenile chronic lymphocytic leukemia are also discussed.
目次
Part I. Introduction
The Natural History of CLL: Historical Perspective
Gerald E. Marti and Vincent Zenger
Part II. Biology and Genetics
Genetics of B-Cell Chronic Lymphocytic Leukemia
Stephan Stilgenbauer, Peter Lichter, and Hartmut Doehner
Molecular Biology of Chronic Lymphocytic Leukemia
William G. Wierda
The Heterogeneous Origin of the B-CLL Cell
Terry Hamblin
Pathogenesis of Impaired Cellular Immune Function in CLL
Patrick B. Johnston and Neil E. Kay
Cytokines and Soluble Molecules in CLL
Enrica Orsini and Robin Foa
Part III. Clinical Aspects: Diagnosis
Immunophenotypic Differential Diagnosis and Cell Cycle Analysis
Vonda K. Douglas and Raul C. Braylan
Common Cytogenetic Abnormalities
Gunnar Juliusson
Immunophenotypic Diagnosis of Leukemic B-Cell Chronic Lymphoproliferative Disorders Other Than Chronic Lymphocytic Leukemia
Alberto Orfao, Julia Almeida, Maria Luz Sanchez, and Jesus F. San Miguel
Part IV. Clinical Aspects: Prognosis
Staging of Chronic Lymphocytic Leukemia, Kanti R. Rai and Niraj Gupta. Prognostic Indicators of Chronic Lymphocytic Leukemia, Francesc Bosch and Emili Montserrat
Part V. Clinical Aspects: Treatment
Guidelines for Clinical Management of CLL
Guillaume Dighiero
Chemotherapy of Chronic Lymphocytic Leukemia
Alessandra Ferrajoli, Michael J. Keating, and Susan M. O'Brien
Autologous and Allogeneic Transplantations for Chronic Lymphocytic Leukemia
Mauricette Michallet
Monoclonal Antibody Therapy in Chronic Lymphocytic Leukemia
Thomas S. Lin, Margaret S. Lucas, and John C. Byrd
Immunotoxin Therapy of Chronic Lymphocytic Leukemia
Arthur E. Frankel and Robert J. Kreitman
New Treatment Strategies in Chronic Lymphocytic Leukemia
Upendra P. Hegde and WyndhamH. Wilson
Gene Therapy of Chronic Lymphocytic Leukemia
Januario E. Castro and Thomas J. Kipps
Part VI. Clinical Aspects: Complications
Infections in Patients With Chronic Lymphocytic Leukemia
Gerald P. Bodey, Dimitrios Kontoyiannis, and Michael J. Keating
Autoimmune and Hypersplenic Cytopenias
Terry Hamblin
Clonal Evolution and Second Malignancies in B-CLL
Guy B. Faguet
Part VII. Familial and Juvenile Chronic Lymphocytic Leukemia
Inherited Predisposition to Chronic Lymphocytic Leukemia
Martin R. Yuille, Daniel Catovsky, and Richard S. Houlston
Young Patients With Chronic Lymphocytic Leukemia
Francesca R. Mauro and Robin Foa
Index
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